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N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry
Siberian Branch of Russian Academy of Science

Special project



Laboratory for Organic Compounds Structure, Properties and Reaction Mechanisms

The main area of the laboratory research is the study of the organic compounds structure and the mechanisms of chemical reactions involving radicals, radical ions, carbo-cations applying the methods of magnetic resonance, X-ray spectroscopy, nuclear magnetic resonance spectroscopy, electron paramagnetic resonance (EPR) and EPR imaging, infrared spectroscopy . Objects of the research are new functional nano-structured materials, molecular magnets (including thermal / light-switchable), and porous metal-organic polymers of different types that are promising for applications in spintronics and nanotechnology, as well as newly synthesized organic compounds.

Another area of ​​research is the use of EPR spectroscopy to solve important biological problems, in obtaining information about the structure of protein complexes and nucleic acids in liquids on the nanometer scale applying the method of spin probes using trityl and nitroxides radicals synthesized at the Institute of Organic Chemistry SB RAS. New approaches and unique combinatory techniques for the study of nanomaterials and biopolymers have been developed.

The results of the laboratory functioning are the following:

  •  The plant for the perfusion of rat hearts has been developed to carry out retrograde perfusion and to observe contractile function in isolated rat hearts placed directly in the cavity of the EPR spectrometer. Measurements of oxygen and pH concentration of the myocardial tissue have been accomplished using EPR on the perfused rat heart;
  •  The molecular structure of a number of biologically active compounds, novel derivates of nitroxides radicals, promising organic materials with different conductive and optical properties has been identified; electrochemistry C (sp2) -linked Nitron-nitroxyl biradicals has been investigated, the electrochemical desoxidation and oxidation of a number of Nitron-nitroxyl radicals;
  •  The properties of new thermal and light-switching molecular nanomagnets based on copper complexes with nitroxyl radicals have been studied. The mechanism of light-induced switching of spin states in these systems as well as the critical factors that determine the stability of the light-induced state have been determined;
  •  EPR and IR spectroscopy methods have been used to study a series of porous metal-polymer whose structure is switchable under the influence of temperature and / or sorption / desorption of guest molecules; The mechanism of recombination reactions and disproportioning of nitroxyl radicals with alkyl (modeling acrylate and styrene monomer radicals) and oxy-centered radicals (hydroxyl, superoxide, etc.) has been studied. The factors affecting constants of recombination rates (steric hindrance, polarity, stabilization).

Partners Laboratories: International tomographic Center, Siberian Branch of the Russian Academy of SciencesUniversity of Provence (Marseille, France)Tohoku University (Japan), Univeristy of Mülheim (Germany).

Head of the Laboratory: Doctor in Physics and Mathematics Elena BagryanskayaThis email address is being protected from spambots. You need JavaScript enabled to view it.

Division of Organic Chemistry Department of Natural Sciences at NSU
Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences

New Drugs Laboratory

The main objective of the laboratory is the development of new antiviral and antitumor drugs on the basis of available natural compounds, and mainly monoterpenoids.

The use of natural compounds as the basis for the development of new drugs is one of the most important trends of modern medicinal chemistry. This is largely due to the inherent complementarity of natural substances to many targets in the organism, the presence of substantial amounts of saturated carbon atoms and asymmetric centers. One of the most common natural compounds is monoterpenoids. So far, monoterpenoids role in the creation of new drugs is low because of the difficulties relative to their chemical modification.

Main results from the laboratory:

  •  For the first time a method of selective catalytic hydrogenation was developed using nanosized gold catalysts in order to obtain dihydrocarvone - a valuable precursor for biologically active substances;
  •  On the basis of common natural substances was held the targeted synthesis of a large range of new compounds took place, which is promising for the study of their biological activity;
  •  As a result of studies on the antitumor activity of obtained substances were determined highly active compounds-leaders were established, which is promising for further development;
  •  Discovery of compounds that develop high activity against Influenza.

Laboratory research is conducted in partnership with the Research Institute of Influenza in St Petersburg, the University of Auckland (Auckland, New Zealand) and the Academy of Abo (Turku, Finland.)

Expert in this field – Doctor of Chemical Sciences Nariman F. Salakhutdinov, This email address is being protected from spambots. You need JavaScript enabled to view it.

Institute of Medicine and Psychology NSU
Novosibirsk Institute of organic chemistry, Siberian Branch of the Russian Academy of Sciences
Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences
Institute of Chemical Biology and Fundamental Medicine,Siberian Branch of the Russian Academy of Sciences

Free Radical Chemistry Laboratory

As part of the laboratory research molecular design, development of methods for the synthesis and study of properties of new stable organic radicals (nitroxide, triarylmethyl) for various applications (in biophysics, structural biology, medicine, materials science, etc.) are conducted. The study of stable chalcogen-diazol ions radical has been carried out. On their basis, new magnetic materials and other materials for organic electronics are being developed. Using synthesized spin labels the interaction of protein molecules and nucleic acids is studied. Such interaction plays the key role in the life of living systems and the development of pathological processes. The role of free radicals in the aging process as well as the influence of antioxidants of different nature on the development of senile pathologies has been studied.

The results of the laboratory research are the following:

  •  The ability of the mitochondrial antioxidant SkQ1 to hinder the development associated with the activation of free radical processes of age-related diseases has been studied;
  •  A large set of new spin labels based on trityl radicals and nitroxyl radicals with spirocyclic fragments surrounded by a nitroxyl group, distinguished by their high electron spin relaxation time has been synthesized;
  •  Methodology of synthesis has been developed and a number of stable nitroxyl radicals of 2,5-dihydroimidazole type have been obtained. Such radicals contain the fragment of heterocycle moiety ortho-hydroxyphenyl in the 4th-position, so-called paramagnetic Schiff base; The formation of unusual tridentate mono and binuclear complexes of 2- (o-pyridyl) substituted radical with hexafluoroacetylacetonate and copper acetate, respectively, has been demonstrated;
  •  Antihypertensive activity of mitochondria-targeted nitroxides pyrrolidine type has been studied.

Head of Laboratory: Doctor in Chemistry, Prof. Vladimir A. Reznikov, This email address is being protected from spambots. You need JavaScript enabled to view it.

Division of Organic Chemistry Department of Natural Sciences NSU
V. V. Voevodskiy Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences


Laboratory for Structures and Functional Properties of Molecular Systems

The Laboratory was established within the section of Chemical and Biological Physics and conducts research in collaboration with the Voevodsky Institute of Chemical Kinetics and Combustion of the SB RAS on the following themes:

  •  structure and dynamics of biological molecules;
  •  creation of new functional molecular materials, promising for electronics, and the study of their properties;
  •  study of the properties of new molecular materials for the energy sector;
  •  optical properties of nanoparticles, including amplification of the radiation of molecules.

The laboratory reached the following results:

  •  It was shown that the lifetime of optical phonons in Diamond is determined by an anharmonic interaction, involving both three-particle interaction (relaxation via the Klemens channel), and four-particle interaction. Thereby we obtained a final answer to the question which was offered various solutions for the last 60 years.
  •  We developed a method to determine the mass of DNA in blood cells using Raman Raman spectroscopy (and without using dyes).
  •  We obtained results in the development of the discrete dipole approximation - a universal method for modeling the linear interaction of electromagnetic waves with small particles of arbitrary shape and structure.
  •  We developed an effective algorithm which is applicable to a wide range of particle size - from nanoparticles to much larger wavelength. The method has been optimized for highly elongated and flattened nanoparticles and to simulate the scattering of femtosecond laser pulses.
  •  We detected long-range (up to 10 nm) intermolecular interactions in biological membranes and long-range reciprocal regulation of molecules.
  •  We set a 3D magnetic motive with ferromagnetic and antiferromagnetic exchange interactions in order to synthetize Heterospin Radical-Ion salt Bis(mesitylen) molybdenum and Radical-Anion Salt[1,2,5]Thiadiazolo[1,2,5]thiadiazolidyl by quantum chemical calculations.
  •  With the help of high-level ab initio calculations (SOC-CASSCF/NEVPT2) we established the electronic structure and explained the properties of Rhenium Complex with Noninnocent Dioxolene Ligand.
  •  For the elaboration of P3HT/PCBM composites for organic photovoltaic we determined the average distance between the radicals P3HT + and PCBM-, forming a charge-transfer state at 2-3 nm.

Expert in this field – Doctor of Physico-Mathematical Sciences, Sergey A. DdzubaThis email address is being protected from spambots. You need JavaScript enabled to view it.

Section of Chemical and biological physics
Section of biomedical physics
Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russiab Academy of Sciences
Vorozhtsov Institute of Organic Chemistry, Siberisn Branh of the Russian Academy of Sciences
Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences