p-Tyrosol, aurol, 4-(2-hydroxyethyl)-phenol is synthetic structural analogue of the main active ingredient herb Rhodiola rosеa L. (Rodiola rosea or Golden root). p-Tyrosol refers to low-toxic , highly biologically active substances and manifests in low doses expressed stimulating and adaptogenic properties. p-Tyrosol known as a prophylactive treatment of viral diseases as a stimulator of the body’s defense capabilities in the chemical, biological and physical effects as a drug for the treatment of patients with schizophrenia, neurosis, cancer, skin diseases, adrenal disorders of the thyroid, thymus glands and increased activity of the gonads. p-Tyrosol exhibits cardioprotective effect in stress myocardial lesions, has a pronounced adaptogenic action, used for rearing animals and birds. As a powerful p-Tyrosol is used to prevent public health from effects of stress on the human organism.
p-Tyrosol is a white crystalline powder with a melting point 92oC and pleasant smell, stable during long-term storage.In N.N.Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences a new process was developed for obtaining 4-(2-hydroxyethyl)-phenol of high purity (not less than 99.5%), suitable for intravenous administration in an aqueous solution of the patient’s organism, suffering from congestive heart failure in order to reduce damage to the heart muscle.
The main advantages of this method are the safe production, use of available domestic raw materials, high purity product, allowing treatment of acute manifestations of the disease doses 40-50 times greater than preventive.
Patent (RU) No. 2385858 «A method of preparation 4-(2-hydroxyethyl)-phenol in high purity».
FIELDS of APPLICATION
p-Tyrosol is adaptogen of a wide spectrum of action and can be used as:
- A preparation to fight the socially dangerous diseases,
- A preparation to reduce road accidents by increasing attention and speed of responses from drivers of vehicles,
- A treatment for drug addiction,
- A preparation of increasing the productivity of animal husbandry.
- Preserving medicine.
- Therapeutic medicine (For companies producing dosage forms).
- Veterinary for increasing productivity and reduce mortality in animals and birds.
LEVEL of PRACTICAL IMPLEMENTATIONIn pilot plant of N.N.Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences was developed technological rules and other necessary documentation for production of p-Tyrosol , were obtained pilot batches. Successfully completed testing of pilot batches of p-Tyrosol in livestock and poultry. Clinical trials of p-Tyrosol held for treatment of cardiovascular diseases.
- Search for partners to release dosage forms.
- Organization of joint industrial production.
N.N.Vorozhtsov Novosibirsk Institute of Organic Chemistry,
Siberian Branch of the Russian Academy of Sciences
Promote Applied Research Department
9, Acad. Lavrentiev Ave, 630090, Novosibirsk 90, Russia
Tel.: +7(383) 330-96-61
Fax: +7(383) 330-97-52