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Федеральное государственное бюджетное учреждение науки
Новосибирский институт органической химии им. Н.Н. Ворожцова
Сибирского отделения Российской академии наук

В журналу ACS Sustainable Chem. Eng. (IF 6,97) опубликована статья с участием сотрудницы Института   д.х.н. М.В. Еделевой (снс, ЛМР):

No Catalyst Added Hydrogen Peroxide Oxidation of Dextran: An Environmentally Friendly Route to Multifunctional Polymers

 

Abstract

The paper demonstrates a “greener” oxidation of dextran polymer of various molecular masses, the component of many industrially and pharmaceutically important materials, by aqueous H2O2 in a no catalyst added setting that produced a multifunctional oxidized dextran. Specifically, on the top of common functional groups (hydroxo, carbonyl, and carboxylic acids), the freshly peroxide oxidized dextran had also a significant number of peroxo-groups, which endowed the polymer with significant cytotoxic properties, as demonstrated on a larynx carcinoma cell line. We also have shown that the peroxo-groups could be easily removed in an alkaline media to yield nontoxic oxidized dextran polymers.

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