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Федеральное государственное бюджетное учреждение науки
Новосибирский институт органической химии им. Н.Н. Ворожцова
Сибирского отделения Российской академии наук

На сайте журнала Applied Catalysis A: General   (IF=5.006) опубликована статья  с участием сотрудников Института: Е.С. Можайцева (мнс, ЛНТПС), к.х.н.Е.В. Суслова (зам.директора по науке, завлаб ЛНТПС)б д.х.н., проф. РАН К.П. Волчо (гнс, ЛФАВ) и  чл.-корр. РАН, д.х.н., проф.  Н. Ф. Салахутдинова (рук. отдела ОМХ, завлаб ЛФАВ)


Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process

Yu.S.Demidova, E.S.Mozhaitsev, E.V.Suslov, A.A.Nefedov, A.A.Saraev, K.P.Volcho, N.F.Salakhutdinov, A.Simakov, I.L.Simakova, D.Yu.Murzine

Applied Catalysis A: General

Available online 21 August 2020, 117799


 https://doi.org/10.1016/j.apcata.2020.117799

 020_08_AppCat.jpg

Abstract

In the current work gold nanoparticles supported on oxides (MgO, Al2O3, ZrO2, TiO2) were used for menthylamine synthesis via menthone oxime hydrogenation. An increase of the gold nanoparticles size and application of metal oxides with a strong basic character such as magnesia favored deoximation to menthone. Au/Al2O3 catalyst with the gold nanoparticles size of 2.0 nm afforded high catalytic activity and selectivity to menthylamine. The reaction kinetics including stereoselectivity to the reaction products and recyclability of the catalyst was studied using Au/Al2O3 in the temperature range 90-110 °C under hydrogen pressure of 5.5-7.5 bar. The catalytic behavior was influenced by the solvent nature, with higher selectivity to desired amine achieved using methanol. The reaction rate was pressure independent, while has first order with respect to menthone oxime concentration. Stereoselectivity to menthylamines and menthones was independent on the reaction temperature and the hydrogen pressure.

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