Журналы

В журнале  Успехи химии/Russian Chemical Reviews  (IF 3.991) опубликован обзор сотрудников Института

Г.И. Бородкина и В.Г. Шубина

Прогресс и перспективы использования фотокатализа в синтезе фторорганических соединений

Progress and prospects in the use of photocatalysis for the synthesis of organofluorine compounds

Анотация

Обобщены и проанализированы данные по синтезу фторированных органических соединений с использованием фотокатализа. Особое внимание уделено рассмотрению механизмов фотокаталитических реакций и проблеме селективности.
Библиография — 173 ссылки.

Abstract

Data on the synthesis of fluorinated organic compounds by photocatalysis are systematically considered and analyzed. The attention is focused on the mechanisms of photocatalytic reactions and the selectivity problem.
The bibliography includes 173 references.

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Государственное бюджетное профессиональное образовательное учреждение Новосибирской области Новосибирский химико-технологический коллежд им. Д.И. Менделеева (ГБПОУ НСО Новосибирский химико-технологический коллежд им. Д.И. Менделеева) СЕРТИФИКАТ ДЕРЯБИНОЙ  Юлии Михайловне (ведущий инженер ЛМА) ЗА УЧАСТИЕ В СОСТАВЕ ЖЮРИ "Менделеевские чтения" Всероссийский научно-практический форум для обучащихся образовательных организаций, реализующих программы среднего профессионального образования >

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Showcasing collaborative research from Rijksuniversiteit Groningen in The Netherlands, Lomonosov Moscow State University, Novosibirsk State University and Vorozhtsov Novosibirsk Institute of Organic Chemistry, Russia Long-range exciton transport in brightly fluorescent furan/phenylene co-oligomer crystals Design of materials combining bright luminescence and charge transport is one of the strategic challenges in organic optoelectronics. Extremely light doping of organic crystals with highly fluorescent molecules enhances the luminescence provided the exciton diffusion length is long enough to reach the dopant and have the exciton energy transferred to the dopant. We present a comprehensive study of singlet exciton diffusion in a brightly luminescent doped semiconductor crystal. The high potential of this material is demonstrated by fabricating solution-processed organic light-emitting transistors. As featured in: ISSN 2050-7526 REVIEW ARTICLE Jihyun Kim et al. Radiation damage effects in Ga 2 O 3 materials and devices Journal of Materials Chemistry C Materials for optical, magnetic and electronic devices rsc.li/materials-c Volume 7 Number 1 7 January 2019 Pages 1–190 rsc.li/materials-c Registered charity number: 207890 See Maxim S. Kazantsev, Dmitry Yu. Paraschuk, Maxim S. Pshenichnikov et al., J. Mater. Chem. C, 2019,

First published: 22 October 2018

Volume 130, January 2019, Pages 581-593


 https://doi.org/10.1039/C8TC04151B

Abstract

The design of light-emitting crystalline organic semiconductors for optoelectronic applications requires a thorough understanding of the singlet exciton transport process. In this study, we show that the singlet exciton diffusion length in a promising semiconductor crystal based on furan/phenylene co-oligomers is 24 nm. To achieve this, we employed the photoluminescence quenching technique using a specially synthesized quencher, which is a long furan/phenylene co-oligomer that was facilely implanted into the host crystal lattice. Extensive Monte-Carlo simulations, exciton–exciton annihilation experiments and numerical modelling fully supported our findings. We further demonstrated the high potential of the furan/phenylene co-oligomer crystals for light-emitting applications by fabricating solution-processed organic light emitting transistors.

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В журнале European Journal of Medicinal Chemistry Volume 161, 1 January 2019, Pages 581-593  (IF=4,816) опубликована статья с участием сотрудников Института:

О.А. Лузиной, Д.Н. Соколова, К.П. Волчо, Н.Ф.Салахутдинова

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models

First published: 05 October 2018

Volume 130, January 2019, Pages 581-593


 https://doi.org/10.1016/j.ejmech.2018.10.055

Abstract

The druggability of the tyrosyl-DNA phosphodiesterase 1 (Tdp1) enzyme was investigated in conjunction with topoisomerase 1 inhibition. A novel class of thiazole, aminothiazole and hydrazonothiazole usnic acid derivatives was synthesized and evaluated as Tdp1 inhibitors and their ability to sensitize tumors to topotecan, a topoisomerase inhibitor in clinical use. Of all the compounds tested, four hydrazinothiazole derivatives,  20c, 20d, 20h and 20i, inhibited the enzyme in the nanomolar range. The activity of the compounds was verified by affinity experiments as well as supported by molecular modelling. The most effective Tdp1 inhibitor, 20d, was ton-toxic and increased the effect of topotecan both in vitro and in vivo in the Lewis lung carcinoma model. Furthermore, 20d showed significant increase in the antitumor and antimetastatic effect of topotecan in mice. The results presented here justify compound 20d to be considered as a drug lead for antitumor therapy.

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В журнале Free Radical Biology and Medicine (IF=6,02) опубликована статья с участием сотрудников Института О.Ю. Рогожниковой, Д. В. Трухина, В.М. Тормышева

A radical containing injectable in-situ-oleogel and emulgel for prolonged in-vivo oxygen measurements with CW EPR

Abstract

Molecular oxygen, reactive oxygen species and free radicals derived from oxygen play important roles in a broad spectrum of physiological and pathological processes. The quantitative measurement of molecular oxygen in tissues by electron paramagnetic resonance (EPR) has great potential for understanding and diagnosing a number of diseases, and for developing and guiding therapies. This requires improvements in the free radical probe systems that sense and report molecular oxygen levels in vivo. We report on the encapsulation of existing free radical probes in lipophilic gel implants: an in-situ-oleogel and an emulgel, based only on well-known, safe excipients for the incorporation of lipophilic and hydrophilic radicals, respectively. The EPR signals of encapsulated radicals were not altered compared to dissolved radicals. The high solubility of oxygen in lipophilic solvents enhanced oxygen sensitivity. The gels extended the lifetime of the radicals in tissues from tens of minutes to many days, simplifying studies with extended series of measurements. The encapsulated radicals showed a good in vivo response to changes in oxygen supply and seem to circumvent concerns from toxicity of the radical probes. These gels simplify the development of new oxygen-sensitive free radical probes for EPR oximetry by making their in vivo stability, persistence and toxicity a function of the encapsulating gel and not a set of additional requirements for the free radical probe.

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В журнале Chemistry - A European Journal  Volume 25, Issue 11, February 21, 2019, Pages 2684-2694 (IF=5,16) опубликован миниобзор  с участием сотрудника Института А.М. Агафонцева

Molecular Receptors for Recognition and Sensing of Nucleotides

Abstract

Nucleotides are constituents of nucleic acids and they have a variety of functions in cellular metabolism. Synthetic receptors and sensors are required to reveal the role of nucleotides in living organisms and mechanisms of signal transduction events. In recent years, a large number of nucleotide‐selective synthetic receptors have been devised, which utilize different molecular designs and sensing mechanisms. This Minireview presents recent progress in the design of synthetic molecular receptors for selective recognition of nucleotides in aqueous solution. The binding properties of receptors and the origins of their selectivity for a particular nucleotide are discussed.

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В журнале Chemistry - A European Journal  (IF 5,16) опубликована статья с участием сотрудника Института А.М. Агафонцева

Anthracene‐Based Cyclophanes with Selective Fluorescent Responses for TTP and GTP: Insights into Recognition and Sensing Mechanisms

Abstract

Three anthracene‐based cyclophanes were synthesized and their binding properties towards nucleoside triphosphates were studied. A new polycyclic amine derived from dearomatized anthracene was identified as a major side product in the cyclization reaction between 9,10‐anthracenedicarboxaldehyde and diethylenetriamine. Its structure was determined by single‐crystal X‐ray analysis. The cyclophanes were found to form 1:1 complexes with all nucleoside triphosphates as well as with pyrophosphate in a buffered aqueous solution at pH 6.2. A turn‐on fluorescence response was observed for all nucleotides except for GTP, which demonstrated strong fluorescence quenching. The strongest turn‐on fluorescence was observed for the largest receptor 3 in the presence of thymidine triphosphate (TTP). Based on the NMR and fluorescence experiments, two major binding modes for nucleotide complexes were identified.

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ORGEL-2019 is aimed at personal contacts and direct exchange and discussion of the newest research information relevant to organic electronics in a broader sense. Thematically, it embraces all related topics such as the design, synthesis and characterization of new low- and high-molecular organic (organoelement, coordination, etc.) compounds and materials; design, manufacturing and functional characterization of devices; as well as experimental and theoretical methods applied in the field. 
It is planned to have invited talks (30 minutes), oral talks (20 minutes) and poster sessions.

Akademgorodok is the world-famous scientific and educational center. It is located 20 kilometers away from Novosibirsk. The unique atmosphere of research and development of the Akademgorodok is created by its over 30 scientific research institutes and Novosibirsk State University, all located in pristine natural surroundings.

The Workshop continues previous events within extended framework of the Leverhulme Trust / Core-to-Core Joint Workshops on Organic Electronics of Highly-Correlated Molecular Systems.

The official language of the Conference is English.

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Российское химическое общество им. Д.И. Менделеева Государственное бюджетное профессиональное образовательное учреждение Новосибирской области Новосибирский химико-технологический коллежд им. Д.И. Менделеева (ГБПОУ НСО Новосибирский химико-технологический коллежд им. Д.И. Менделеева) БЛАГОДАРСТВЕННОЕ ПИСЬМО ДЕРЯБИНОЙ  Юлии Михайловне (ведущий инженер ЛМА) ЗА УЧАСТИЕ В СОСТАВЕ ЖЮРИ "Менделеевские чтения" научно-практический форум для студентов государственных профессиональных образовательных учреждений Новосибирской области

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В пятницу,  22 февраля 2019 г. , в 09-30 в конференц–зале НИОХ

состоится заседание № 6 Объединенного научного семинара

Повестка заседания:

Статья  в Journal of Fluorine Chemistry

Vladimir N. Kovtonyuk, Yuri V. Gatilov, Georgi E. Salnikov,
Evgeni V. Amosov


Polyfluorinated tetraoxacalixarenes and bicyclooxacalixarenes.
Interaction of pentafluorobenzonitrile with resorcinol, orcinol
and tetrafluororesorcinol

Докладчик - В.Н. Ковтонюк

Рецензент – Пешков Роман Юрьевич

Статья  в ЖОрХ

Я.В. Зонов, В.М. Карпов, Т.В. Меженкова


Карбонилирование полифторбензоциклобутенонов в среде SbF₅

Докладчик - Я.В. Зонов 

Рецензент – Чуйков Игорь Петрович