DEVELOPMENT OF NEW DRUGS FOR SPECIAL DANGER INFECTIONS AND TREATMENT OF SOCIALLY MEANINGFUL DESEASES

DEVELOPMENT  OF  NEW DRUGS FOR SPECIAL DANGER INFECTIONS AND TREATMENT OF SOCIALLY MEANINGFUL DESEASES

On the basis of fundamental research, there has been developed an ideology of search for biologically active compounds and new drugs from readily available plant metabolites.

On the basis of the general synthetic approaches there has been realized a research program on selective transformations of plant terpenoids, alkaloids, and metabolites of phenolic type.   

It has been formulated and developed a new scientific area: synthesis of commercially valuable polycyclic compounds by heterogeneous-catalytic transformations of large-tonnage dendrochemistry products – monoterpenes.

Collaborative work of the scientists of various scientific and educational institutions of the Siberian Branch of the Russian Academy of Sciences and the Russian Academy of Medical Sciences has made it possible  to  develop  high-performance  anti-HIV  agents  (Betulonic  Acid  Dipeptide,  Patent  of  RF

№ 2211843), agents reducing side effects of cytostatics (Betulonic  Acid  Alanylamide, Grant of patent decision of October 23, 2008 to issue a patent for invention on patent application № 2007 134627/04(037825) of 17.09.2007) and perspective inductors of apoptosis of cancer cells for pre-clinical testing.

Authors:

MSci,  G.A. Tolstikov; PhD. N.F. Salakhutdinov, Head of the department; PhD. E.E.Shults, Head of the laboratory;
PhD. S.A. Osadchii С.А.; PhD. K.P.Volcho; PhD. T.G. Tolstikova, Head of the laboratory;
PhD. I.V.Sorokina  (NIOCH SB RAS);
PhD. A.G.Pokrovsky, Dean of Medical Department (NSU);
PhD. N.K. Popova, Head of the laboratory (Institute of Cytology and Genetics SB RAS).