Head - Cand. Sci.(Chem) Victor M. Tormyshev
Phone: (383) 330-49-81, internal phone: 3-00
The Group was founded in 1999.Up to 01.06.2020 - Group of Metal Complex Catalysis (MCG)
- Spin probes for noninvasive diagnosis of oncologic diseases using the in vivo EPR Oxygen Imaging technologies.
- Spin probes for studying the biopolymer structure, reagents for studying the nuclear Overhauser effect.
- Synthesis of novel organic materials, including polyfunctional nitrogen-, oxygen- and sulfur-containing heterocyclic compounds (physiologically active compounds and synthons for drug production).
- Materials for microelectronics.
The most significant results
- Synthesis of various triarylmethyl (trityl, TAM) radicals, which are stable towards components of cytoplasm, perfectly soluble in water, and demonstrate ultra-narrow singlet signal in ESR spectra. Derivatives of trityls with a broad variation of hydrophilic properties. Synthesis of numerous hybrid trityl-nitroxide bi- and triradicals. These investigations are performed in collaboration with American and Israeli colleagues.
- An access to TAM-based spin- labels focused on SDSL of peptides and oligonucleotides. The first example of high-accuracy measurement of long – up to 46 Å - interspin distances in doubly labeled 10-mer DNAs at physiological temperature (37 oC) using SDSL and DQC ESR techniques. .
- Practical methods for synthesis of water-soluble polymeric electrolytes used in generation of ultra-thin defect-free nanolayers of transient metals.
- Efficient approaches to synthesis of monofunctional derivatives of TAM and multi-spin systems
Project 13-04-00680 "Design of trityl spin labels with optimized properties and their application for structure elucidation of biomolecules using methods of dipole EPR spectroscopy"
The joint RFBR-NSF Project 14-03-93180 "International collaboration in chemistry: Dynamic nuclear polarization by nanoparticles and low-dimensionality aggregates"
- Grant P41 EB002034 from National Institute of Health “Center for Electron Paramagnetic Resonance Imaging in Vivo Physiology”, 2013-2018. The collaborative studies are performed by teams of the University of Chicago, the University of Denver, the University of Maryland, the University of Illinois at Urbana Shampaign (USA), and the Novosibirsk Institute of Organic Chemistry under the auspices of Center for EPR Imaging in vivo Physiology: http://epri.uchicago.edu/. The information resulted from these investigations is crucial for understanding of cancer physiology, radiological treatment improvement, study of stroke, heart attack, peripheral vascular disease and other biomedical problems.
- Project 13-04-00680 "Design of trityl spin labels with optimized properties and their application for structure elucidation of biomolecules using methods of dipole EPR spectroscopy" supported by the Russian Foundation for Basic Research, 2013-2015. The multi-disciplinary study is performed by teams of the Novosibirsk Institute of Organic Chemistry, the International Tomography Center and the Institute of Chemical Biology and Fundamental Medicine.
- The joint RFBR-NSF Project 14-03-93180 "International collaboration in chemistry: Dynamic nuclear polarization by nanoparticles and low-dimensionality aggregates", 2014-2016. The multi-disciplinary study is performed by teams of the Novosibirsk Institute of Organic Chemistry, the Institute of Chemical Kinetics and Combustion and the University of Alabama
- Gérard Audran, Elena G. Bagryanskaya, Paul Brémond, Mariya V. Edeleva, Sylvain R. A. Marque, Dmitriy A. Parkhomenko, Olga Yu. Rogozhnikova, Victor M. Tormyshev, Evgeny V. Tretyakov, Dmitry V. Trukhin and Svetlana I. Zhivetyeva
Trityl-based alkoxyamines as NMP controllers and spin-labels
Polym. Chem., 2016, First published online 12 Oct 2016, DOI:10.1039/C6PY01303A
- Matvey V. Fedin, Georgyi Yu Shevelev, Dmitrii V Pyshnyi, Victor Mikhailovich Tormyshev, Gunnar Jeschke, Maxim Yulikov and Elena G. Bagryanskaya
Interaction of Triarylmethyl Radical with DNA Termini Revealed by Orientation-Selective W-band Double Electron-Electron Resonance Spectroscopy
Phys. Chem. Chem. Phys., 2016, First published online 05 Oct 2016, DOI:10.1039/C6CP05904J
- A.A. Kuzhelev, V.M. Tormyshev, O.Yu. Rogozhnikova, D.V. Trukhin, T.I. Troitskaya, R.K. Strizhakov, O.A. Krumkacheva, M.V. Fedin, E.G. Bagryanskaya
Triarylmethyl Radicals: An EPR Study of 13C Hyperfine Coupling Constants
Zeitschrift für Physikalische Chemie, 2016, Published online 5 Oct 2016, DOI:10.1515/zpch-2016-0811
- Z. Yang, M.D. Bridges, C.J. Lopez, O.Yu. Rogozhnikova, D.V. Trukhin, E.K. Brooks, V. Tormyshev, H.J. Halpern, W.L. Hubbell
A Triarylmethyl Spin Label for Long-Range Distance Measurement at Physiological Temperatures Using T1 Relaxation Enhancement
Journal of Magnetic Resonance, 2016, V.269, Pp. 50–54 doi:10.1016/j.jmr.2016.05.006
- B. Epel, G. Redler, C. Pelizzari, V.M. Tormyshev, H.J. Halpern
Approaching Oxygen-Guided Intensity-Modulated Radiation Therapy
Oxygen Transport to Tissue XXXVII, V.876 of the series Advances in Experimental Medicine and Biolog, Part IV, pp 185-193 doi:10.1007/978-1-4939-3023-4_23
- B. Epel, G. Redler, V. Tormyshev, H.J. Halpern
Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging
Oxygen Transport to Tissue XXXVII, V.876 of the series Advances in Experimental Medicine and Biolog, Part VII, pp 363-369 doi:10.1007/978-1-4939
- D.V. Trukhin, O.Yu. Rogozhnikova, T.I. Troitskaya, V.G. Vasiliev, M. K. Bowman, V. M. Tormyshev
Facile and High-Yielding Synthesis of TAM Biradicals and Monofunctional TAM Radicals
SynLett, 2016, 27. doi:10.1055/s-0035-1561299
- G. Yu. Shevelev, O. A. Krumkacheva, A. A. Lomzov, A. A. Kuzhelev, D. V. Trukhin, O. Yu. Rogozhnikova, V. M. Tormyshev, D. V. Pyshnyi, M. V. Fedin, E.G. Bagryanskaya
Triarylmethyl Labels: Toward Improving the Accuracy of EPR Nanoscale Distance Measurements in DNAs
J. Phys. Chem. B, 2015, 119 (43), pp 13641-13648 doi:10.1021/acs.jpcb.5b03026
- A.A. Kuzhelev, D.V. Trukhin, O.A. Krumkacheva, R.K. Strizhakov, O.Yu. Rogozhnikova, T.I. Troitskaya, M.V. Fedin, V.M. Tormyshev, E. G. Bagryanskaya
Room-Temperature Electron Spin Relaxation of Triarylmethyl Radicals at the X- and Q-Bands
J. Phys. Chem. B, 2015, 119 (43), pp 13630-13640 doi:10.1021/acs.jpcb.5b03027
- G.Yu. Shevelev, O.A. Krumkacheva, A.A. Kuzhelev, A. A. Lomzov, O. Yu. Rogozhnikova, D.V. Trukhin, T. I. Troitskaya, V. M. Tormyshev, M.V. Fedin, D.V. Pyshnyi, E. G. Bagryanskaya.
Physiological- Temperature Distance Measurement in Nucleic Acid using Triarylmethyl-Based Spin Labels and Pulsed Dipolar EPR Spectroscopy
JACS, 2014, 136, 9874-9877. DOI: 10.1021/ja505122n
- V.M. Tormyshev, O.Yu. Rogozhnikova, M.K. Bowman, D.V. Trukhin, T.I. Troitskaya, G.V. Vasiliev, L.A. Shundrin, H.J. Halpern
Preparation of Diversely Substituted Triarylmethyl Radicals by the Quenching of Tris(2,3,5,6-tetrathiaaryl)methyl Cations with C-, N-, P- and S-Nucleophiles.
Eur.J.Org.Chem. 2014, 371-380. DOI: 10.1002/ejoc.201301161
- O.Yu. Rogozhnikova, V.G. Vasiliev, T.I. Troitskaya, D.V. Trukhin, T.V. Mikhalina, H.J. Halpern, V.M. Tormyshev.
Generation of Trityl Radicals via Nucleophilic Quenching of Tris(2,3,5,6-tetrathiaaryl)methyl Cations and Practical and Convenient Large-Scale Synthesis of Persistent Tris(4-carboxyl-2,3,5,6-tetrathiaaryl)methyl Radical.
Eur.J.Org.Chem. 2013, 3347-3355. DOI: 10.1002/ejoc.201300176
- S.N.Trukhan, V.F. Yudanov, V.M. Tormyshev, O. Yu. Rogozhnikova, D.V. Trukhin, M.K. Bowman, M.D. Krzyaniak, H. Chen, O.N. Martyanov.
Hyperfine interactions of narrow-line trityl radical with solvent molecules.
J. Mag. Reson. 2013, 233, 29-36. DOI: 10.1016/j.jmr.2013.04.017
- V.M. Tormyshev, F.V. Genaev, G.E.Sal’nikov, O. Yu. Rogozhnikova, T.I. Troitskaya, D.V. Trukhin, V.I.Mamatyuk, D.S. Fadeev, H.J.Halpern.
Triarylmethanols with Bulky Aryl Groups and the NOESY/EXSY Experimental Observation of a Two-Ring-Flip Mechanism for the Helicity Reversal of Molecular Propellers.
Eur. J. Org. Chem. 2012, 623-629. DOI: 10.1002/ejoc.201101243
- Y. Talmon, L. Shtirberg, W. Harneit, O.Yu. Rogozhnikova, V.Tormyshev, A. Blank.
Molecular diffusion in porous media by PGSE ESR.
Chem.Phys.Phys.Chem., 2010, 12, 5998–6007. DOI: 10.1039/b922060g
- R. Halevy, V. Tormyshev, A. Blank.
Microimaging of Oxygen Concentration near Live Photosynthetic Cells by Electron Spin Resonance.
Biophysical J. 2010, 99, 971–978. DOI: 10.1016/j.bpj.2010.05.002
- V. M. Tormyshev, D. V. Trukhin, O. Yu. Rogozhnikova, T. V. Mikhalina, T. I. Troitskaya, A. Flinn.
Aryl Alkyl Ketones in a One-Pot Gewald Synthesis of 2-Aminothiophenes.
SynLett, 2559 (2006). DOI: 10.1055/s-2006-951484
- V. M. Tormyshev, T. V. Mikhalina, O. Yu. Rogozhnikova, T. I. Troitskaya, D. V. Trukhin.
A Combinatorially Convenient Version of Synthesis of 5-Substituted Oxazole-4-Carboxylic Acid Ethyl Esters.
Russ.J.Org.Chem. 2006, 42, 1031-1035. DOI: 10.1134/S1070428006070177
- D. V. Trukhin, I. Yu. Bagryanskaya, Yu. V. Gatilov, T. V. Mikhalina, O. Yu. Rogozhnikova, T. I. Troitskaya, V. M. Tormyshev.
A Straightforward and Convenient Synthesis of Cbz-Protected 2-(1-Aminoalkyl)oxazole-5-carboxylates.
SynLett, 2072 (2005). DOI: 10.1055/s-2005-871957