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N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry
 Of the Siberian Branch of Russian Academy of Science

(Created: Dec. 30, 2018 )



Suslov E.V.


Head of Lab. 
Ph.D. Evgeny V. Suslov
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
 

 


 

The main activities of the laboratory are:

  • Search and creation of new highly effective, low-toxic domestic drugs for the treatment and prevention of socially significant diseases. The basis of the creation of medicinal agents are such approaches as:
    1. Directed modification of natural compounds (alkaloids, terpenoids, coumarins, flavonoids, etc.)
    2. Analysis and modification of structures of known natural biologically active compounds;
  • Creation of highly efficient and safe drug delivery systems based on natural compounds and their derivatives;
  • Development of new regioselective and stereoselective approaches and synthesis methods for the modification of natural compounds for the production of target substances;
  • Improving the structure of leading compounds in order to increase their pharmacodynamic and pharmacokinetic characteristics, as well as activity and selectivity, using for this purpose techniques such as the synthesis of structural analogs based on the principle of three-dimensional pharmacophore similarity, changing the conformational mobility of the original molecule, bioisteric replacement, changing the balance of lipophilic and hydrophilic groups, creating peptidomimetics, changing metabolizable groups, etc.

Partners of the laboratory:


• Novosibirsk State University;

• Moscow State University;

• School of Chemistry, University of Auckland (New Zealand);

• Institute of Chemical Biology and Fundamental Medicine;

• Institute of Catalysis;

• Abo University (Finland);

• St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology;

• State Research Center of Virology and Biotechnology VECTOR;

Staff

№ Employee Position Room Phone Phone in. email Publications
by yearsby tipeby If
1 Suslov Evgeny Vladimirovich Senior Researcher (Cand. Chem.) 215, 103 330-88-51, 330-88-70 3-40, 4-46 This email address is being protected from spambots. You need JavaScript enabled to view it.
2 Ponomarev Konstantin Yurievich Researcher (Cand. Chem.) 103 330-88-70 4-46 This email address is being protected from spambots. You need JavaScript enabled to view it.
3 Brusentseva Olga Igorevna Junior Researcher 101 330-56-50 3-86 This email address is being protected from spambots. You need JavaScript enabled to view it.
4 Kovaleva Kseniya Sergeevna Junior Researcher 205 330-88-70 2-25 This email address is being protected from spambots. You need JavaScript enabled to view it.
5 Kuranov Sergey Olegovich Junior Researcher 204 330-88-70 2-21 This email address is being protected from spambots. You need JavaScript enabled to view it.
6 Lastovka Anastasiya Valerievna Junior Researcher 126 330-65-54 3-73 This email address is being protected from spambots. You need JavaScript enabled to view it.
7 Li-Zhulanov Nikolai Sergeevich Junior Researcher 129 330-88-70 3-96 This email address is being protected from spambots. You need JavaScript enabled to view it.
8 Mozhaitsev Evgeny Sergeevich Junior Researcher 103 330-88-70 4-46 This email address is being protected from spambots. You need JavaScript enabled to view it.
9 Podturkina Alexandra Vladimirovna Junior Researcher 129 330-88-70 3-96 This email address is being protected from spambots. You need JavaScript enabled to view it.
10 Filimonov Alexander Sergeevich Junior Researcher 204 330-88-70 2-57 This email address is being protected from spambots. You need JavaScript enabled to view it.
11 Chernyshev Vladimir Vladimirovich Junior Researcher 205 330-88-70 2-25 This email address is being protected from spambots. You need JavaScript enabled to view it.
12 Shirokova Elizaveta Dmitrievna Junior Researcher 204 330-88-70 2-21 This email address is being protected from spambots. You need JavaScript enabled to view it.
13 Munkuev Aldar Ayurovich engineer 103 330-88-70 4-46 This email address is being protected from spambots. You need JavaScript enabled to view it.
14 Kuznetsova Darya Andreevna laboratory assistant

 

Публикации за последние 5 лет 

 

Публикации сотрудников подразделения (БД НИОХ СО РАН) 1 (2015 - 2020 )

Обзоры, статьи в научных журналах


    2019
  1. V.V. Chernyshov, O.I. Yarovaya, D.S. Fadeev, Yu.V. Gatilov, Ya.L. Esaulkova, A.S. Muryleva, K.O. Sinegubova, V.V. Zarubaev, N.F. Salakhutdinov
    Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity
    Molecular Diversity, First Online: 28 February 2019 doi:10.1007/s11030-019-09932-9, IF=2.032
  2. K. Kovaleva, O. Oleshko, E. Mamontova, O. Yarovaya, O. Zakharova, A. Zakharenko, A. Kononova, N. Dyrkheeva, S. Cheresiz, A. Pokrovsky, O. Lavrik, N. Salakhutdinov
    Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells
    Journal of Natural Products, Publication Date (Web):August 20, 2019 doi:10.1021/acs.jnatprod.8b01095, IF=4.256
  3. A.A. Chepanova, E.S. Mozhaitsev, A.A. Munkuev, E.V. Suslov, D.V. Korchagina, O.D. Zakharova, A.L. Zakharenko, Ji. Patel, D.M. Ayine-Tora, J. Reynisson, I.K. H. Leung, K.P. Volcho, N.F. Salakhutdinov, O.I. Lavrik
    The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges
    Applied Sciences, 2019, 9(13), 2767 doi:10.3390/app9132767, IF=2.217
  4. И.В. Нечепуренко, Е.Д. Широкова, М.В. Хвостов, Т.С. Фролова, О.И. Синицина, А.М. Максимов, Р.А. Бредихин, Н.И. Комарова, Д.С. Фадеев, О.А. Лузина, Т.Г. Толстикова, Н.Ф. Салахутдинов
    Синтез, гиполипидемическая и противогрибковая активность сульфонатов тетрагидроберберрубина
    Известия Академии наук. Серия химическая, 2019, Т. 68, N 5, Cc. 1052-1060 (Synthesis, hypolipidemic and antifungal activity of tetrahydroberberrubine sulfonates/ I. V. Nechepurenko, E. D. Shirokova, M. V. Khvostov, T. S. Frolova, O. I. Sinitsyna, A. M. Maksimov, R. A. Bredikhin, N. I. Komarova, D. S. Fadeev, O. A. Luzina, T. G. Tolstikova, N. F. Salakhutdinova// Russian Chemical Bulletin, 2019, V. 68, N 5, pp 1052-1060 doi:10.1007/s11172-019-2519-y), IF=1.014
  5. E.Mozhaitsev,E.Suslov,Yu. Demidova,D. Korchagina,K.Volcho,A. Zakharenko,I. Vasi'eva,M.Kupryushkin,A. Chepanova,D. M. Ayine-Tora,J.Reynisson,N. Salakhutdinov,O. Lavrik
    The Development of Tyrosyl-DNA Phosphodyesterase 1 (TDP1) Inhibitors Based on the Amines Combining Aromatic/Heteroaromatic and Monoterpenoid Moieties
    Letters in Drug Design & Discovery, 2019, V. 6, N 5, Pp 597-605 doi:10.2174/1570180816666181220121042, IF=0.953
  6. E.S. Mozhaitsev, A.L. Zakharenko, E.V. Suslov, D.V. Korchagina, O.D. Zakharova, I.A. Vasil’eva, A.A. Chepanova, E. Black, J. Patel, R. Chand, J. Reynisson, I.K. H. Leung, K.P. Volcho, N.F. Salakhutdinov, O.I. Lavrik
    Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments
    Anti-Cancer Agents in Medicinal Chemistry, 2019, V. 19 , N 4 , Pp 463-472 doi:10.2174/1871520619666181207094243, IF=2.18
  7. N.S. Li-Zhulanov, I.V. Il’ina, A. Chicca, P. Schenker, O.S. Patrusheva, E.V. Nazimova, D.V. Korchagina, M. Krasavin, K.P. Volcho, N.F. Salakhutdinov
    Effect of chiral polyhydrochromenes on cannabinoid system
    Medicinal Chemistry Research, 2019, V. 28, N 4, pp 450-464 doi:10.1007/s00044-019-02294-9, IF=1.72
  8. Е.В. Суслов, К.Ю. Пономарев, Д.В. Корчагина, К.П. Волчо, Н.Ф. Салахутдинов
    Синтез диазаадамантанов на основе 1,5-диметилбиспидинона и некоторых природных кетонов
    Известия Академии наук. Серия химическая. 2019. № 3. С. 601-605. (Synthesis of diazaadamantanes from 1,5-dimethylbispidinone and some natural ketones/ Suslov E.V.1, Ponomarev K. Yu.1, Korchagina D.V.1, Volcho K.P.1,2, Salakhutdinov N.F.// Russian Chemical Bulletin, 2019, V. 68, N 3, pp 601-605 doi:10.1007/s11172-019-2461-z), IF=1.014
  9. N. Dyrkheeva, O. Luzina, A. Filimonov, O. Zakharova, E. Ilina, A. Zakharenko, M. Kuprushkin, D. Nilov, I. Gushchina, V. Svedas, N. Salakhutdinov, O. Lavrik
    Inhibitory Effect of New Semisynthetic Usnic Acid Derivatives on Human Tyrosyl-DNA Phosphodiesterase 1
    Planta Medica, 2019, V. 85, N 2, Pp 103-111 doi:10.1055/a-0681-7069, IF=2.746

Тезисы докладов на конференциях

  1. К.П. Волчо, О.А. Лузина, А.Л. Захаренко, Т.М. Хоменко, О.В. Саломатина, Е.В. Суслов, О.Д. Захарова, Й. Рейниссон, О.И. Лаврик, Н.Ф. Салахутдинов
    Новые ингибиторы TDPL - потенциальные антираковые препараты, как задача для структурной биологии
    В книге: Биотехнология - медицине будущего Материалы всероссийской мультиконференции с международным участием. Новосибирск, 2019. С. 129.
  2. E.V. Suslov, E.S. Mozhaitsev, K.Yu. Ponomarev, A.A. Munkuev, A.L. Zakharenko, D.V. Korchagina, O.V. Lavrik, E.A. Morozova, T.G. Tolstikova, K.P. Volcho, N.F. Salakhutdinov
    New biologically active derivatives of adamantana and heteroadamantanes containing monotherpenoid fragments
    Markovnikov Congress on Organic Chemistry, 21-28 June 2019, Moscow-Kazan, Russia, Book of Abstracts, Oral Presentations, P. 201.
  3. I.V. Il’ina, O.V. Ardashov, N.S. Li-Zhulanov, A.Yu. Sidorenko, K.P. Volcho, N.F. Salakhutdinov, D.Yu. Murzin, V.E. Agabekov
    Synthesis of biologically active isobenzofurans starting from 3-carene
    4-я Российская Конференция по Медицинской Химии «МедХим-Россия 2019». г. Екатеринбург, Россия, 9-14 июня 2019 года. Abstract book. P. 353. Стендовый доклад
  4. E.S. Mozhaitsev, A.A. Munkuev, A.L. Zakharenko, E.V. Suslov, D.V. Korchagina, O.D. Zakharova, I.A. Vasil’eva, A.A. Chepanova, K.P. Volcho, N.F. Salakhutdinov, O.I. Lavrik
    Synthesis of amides and thioamides combining adamantane and monoterpene fragments
    4-я Российская Конференция по Медицинской Химии «МедХим-Россия 2019». г. Екатеринбург, Россия, 9-14 июня 2019 года. Abstract book. P. 234
  5. E. Suslov, E. Mozhaitsev, K. Ponomarev, A. Munkuev, A. Chepanova, A. Zakharenko, D. Korchagina, O. Lavrik, E. Morozova, T. Tolstikova, K. Volcho, N. Salakhutdinov
    New biologically active derivatives of adamantane and heteroadamantanes containing monotherpenoid fragments.
    4-я Российская Конференция по Медицинской Химии «МедХим-Россия 2019». г. Екатеринбург, Россия, 9-14 июня 2019 года. Abstract book. P. 117.
  6. О.И. Брусенцева, Ю.В. Харитонов, Э.Э. Шульц
    Синтез полиазамакроциклических соединений на основе фломизоиковой кислоты
    Тезисы докладов XI Всероссийской научной конференции “Химия и технология растительных веществ”. Сыктывкар, 27-31 мая 2019, С. 55
  7. K. Volcho, A. Zakharenko, O. Luzina, T. Khomenko, E. Suslov, O. Salomatina, O. Zakharova, N. Li-Zhulanov, J. Reynisson, O. Lavrik, N. Salakhutdinov
    Tdp1 Inhibition as a Promising Approach to New Anticancer Drugs
    2nd Molecules Medicinal Chemistry Symposium: Facing Novel Challenges in Drug Discovery. Barcelona, Spain,15-17 May 2019,P. 34./ Proceedings 2019, 22(1), 35, DOI:10.3390/proceedings2019022035 (registering DOI)
  8. O.I. Brusentseva, Yu.V. Kharitonov, E.E. Shults
    Synthesis and spectroscopic studies of chiral bis-triazolium macrocycles with a furan bridge possessing structural fragment natural diterpenoids
    Book of Abstracts the Fifth International Scientific Conference Advances in synthesis and complexing. 2019, V.1, P. 109. Moskow, RUDN University, 22-26 апреля 2019 года
  9. K.Yu. Ponomarev, E.V. Suslov, A.V. Pavlova, E.A. Morozova, D.V. Korchagina, T.G. Tolstikova, K.P. Volcho, N.F. Salakhutdinov
    Synthesis of di- and triazaadamantane derivatives containing monoterpene fragments
    4-я Российская Конференция по Медицинской Химии «МедХим-Россия 2019». г. Екатеринбург, Россия, 9-14 июня 2019 года. Abstract book. P. 255

Патенты

  1. О.С. Олешко, К.С. Ковалева, О.И. Яровая, Е.М. Мамонтова, А.Л. Захаренко, О.Д. Захарова, С.В. Чересиз, А.Г. Покровский, О.И. Лаврик, Н.Ф. Салахутдинов
    1-Адамантил-3-(((1R,4aS,10aR)-7-изопропил-1,4а-диметил-1,2,3,4,4а,9,10,10а-октагидрофенантрен-1-ил)метил)мочевина, проявляющая ингибирующее действие в отношении фермента тирозил-ДНК-фосфодиэстеразы 1 человека и увеличивающая активность темозоломида в отношении клеток глиобластомы
    Заявка 2019113591, приоритет от 30.04.2019, Патент RU 2 697 409 , Бюл. № 23, опубликовано: 14.08.2019

 

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