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N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry
 Siberian Branch of Russian Academy of Science

Department of Medical Chemistry

(Created: Dec. 30, 2018 )

 

Suslov E.V.


Head of Lab. 
Ph.D. Evgeny V. Suslov
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
 
Resercher ares

The main activities of the laboratory are:

  • Search and creation of new highly effective, low-toxic domestic drugs for the treatment and prevention of socially significant diseases. The basis of the creation of medicinal agents are such approaches as:
    1. Directed modification of natural compounds (alkaloids, terpenoids, coumarins, flavonoids, etc.)
    2. Analysis and modification of structures of known natural biologically active compounds;
  • Creation of highly efficient and safe drug delivery systems based on natural compounds and their derivatives;
  • Development of new regioselective and stereoselective approaches and synthesis methods for the modification of natural compounds for the production of target substances;
  • Improving the structure of leading compounds in order to increase their pharmacodynamic and pharmacokinetic characteristics, as well as activity and selectivity, using for this purpose techniques such as the synthesis of structural analogs based on the principle of three-dimensional pharmacophore similarity, changing the conformational mobility of the original molecule, bioisteric replacement, changing the balance of lipophilic and hydrophilic groups, creating peptidomimetics, changing metabolizable groups, etc.

Partners of the laboratory:

  • Novosibirsk State University;
     
  • Moscow State University;

  • School of Chemistry, University of Auckland (New Zealand);
     
  • Institute of Chemical Biology and Fundamental Medicine;
     
  • Institute of Catalysis;
     
  • Abo University (Finland);
     
  • St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology;
     
  • State Research Center of Virology and Biotechnology VECTOR.
     

 

STAFF

Staff

№ Employee Position Room Phone Phone in. email Publications
by years
1 Suslov Evgeny Vladimirovich Senior Researcher (Cand. Chem.) 215, 103 330-88-51, 330-88-70 3-40, 4-46 This email address is being protected from spambots. You need JavaScript enabled to view it.
2 Li-Zhulanov Nikolai Sergeevich Researcher 129 330-88-70 3-96 This email address is being protected from spambots. You need JavaScript enabled to view it.
3 Kuranov Sergey Olegovich Researcher (Cand. Chem.) 204 330-88-70 2-21 This email address is being protected from spambots. You need JavaScript enabled to view it.
4 Ponomarev Konstantin Yurievich Researcher (Cand. Chem.) 103 330-88-70 4-46 This email address is being protected from spambots. You need JavaScript enabled to view it.
5 Gladkova Elizaveta Dmitrievna Junior Researcher 204 330-88-70 2-21 This email address is being protected from spambots. You need JavaScript enabled to view it.
6 Kovaleva Kseniya Sergeevna Junior Researcher 205 330-88-70 2-25 This email address is being protected from spambots. You need JavaScript enabled to view it.
7 Mozhaitsev Evgeny Sergeevich Junior Researcher 103 330-88-70 4-46 This email address is being protected from spambots. You need JavaScript enabled to view it.
8 Podturkina Alexandra Vladimirovna Junior Researcher 129 330-88-70 3-96 This email address is being protected from spambots. You need JavaScript enabled to view it.
9 Filimonov Alexander Sergeevich Junior Researcher 204 330-88-70 2-57 This email address is being protected from spambots. You need JavaScript enabled to view it.
10 Chernyshev Vladimir Vladimirovich Junior Researcher 205 330-88-70 2-25 This email address is being protected from spambots. You need JavaScript enabled to view it.
11 Brusentseva Olga Igorevna Junior Researcher (Cand. Chem.) 101 330-56-50 3-86 This email address is being protected from spambots. You need JavaScript enabled to view it.
12 Lastovka Anastasiya Valerievna Junior Researcher (Cand. Chem.) 126 330-65-54 3-73 This email address is being protected from spambots. You need JavaScript enabled to view it.
Students
13 Ismangulova Diana Yurievna laboratory assistant
14 Oreshko Vladislav Victorovich laboratory assistant 205 This email address is being protected from spambots. You need JavaScript enabled to view it.
15 laboratory assistant This email address is being protected from spambots. You need JavaScript enabled to view it.
16 Krinitcina Tatiana Adreevna laboratory assistant 103 This email address is being protected from spambots. You need JavaScript enabled to view it.
PHD Students
17 Stepanova Viktoria Aleksandrovna Junior Researcher 232 330-85-33 2-35 This email address is being protected from spambots. You need JavaScript enabled to view it.
18 Munkuev Aldar Ayurovich Junior Researcher 103 330-88-70 4-46 This email address is being protected from spambots. You need JavaScript enabled to view it.

PUBLICATIONS
 

 

Laboratory staff publications (DB NIOCh)

Reviews, Articles


2021
  1. V.V. Chernyshov, O.I. Yarovaya, S.Z. Vatsadze, S.S. Borisevich, S.N. Trukhan, Yu.V. Gatilov, R.Yu. Peshkov, I.V. Eltsov, O.N. Martyanov, N.F. Salakhutdinov
    Unexpected ring opening during the imination of camphor-type bicyclic ketones
    European Journal of Organic Chemistry, 2021, V. 2021, N 3, Pp 452-463 doi:10.1002/ejoc.202001397, IF=2.888
  2. V. Fomenko, M. Blokhin, S. Kuranov, M. Khvostov, D. Baev, M.S. Borisova, O. Luzina, T.G. Tolstikova, N.F. Salakhutdinov
    Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome
    Sci. Pharm. 2021, 89(1), 4 doi:10.3390/scipharm89010004

2020
  1. K. Kovaleva, E. Mamontova, O. Yarovaya, O. Zakharova, A. Zakharenko, O. Lavrik, N. Salakhutdinov
    Dehydroabietylamine-based thiazolidin-4-ones and 2-thioxoimidazolidin-4-ones as novel tyrosyl-DNA phosphodiesterase 1 inhibitors
    Molecular Diversity (2020), Published: 24 August 2020 doi:10.1007/s11030-020-10132-z, IF=2.13
  2. S. Kuranov, O. Luzina, M. Khvostov, D. Baev, D. Kuznetsova, N. Zhukova, P. Vassiliev, A. Kochetkov, T. Tolstikova, N. Salakhutdinov
    Bornyl Derivatives of p-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity
    Pharmaceuticals 2020, 13(11), 404 doi:10.3390/ph13110404, IF=4.285
  3. А. Чепанова, Н.С. Ли-Жуланов, Т.А. Кургина, А.Л. Захаренко, О.Д. Захарова, К.П. Волчо, Н.Ф. Салахутдинов, О.И. Лаврик
    Разработка ингибиторов tdpi на основе производных хроменов как потенциальных противораковых препаратов
    Гены и Клетки. 2020. Т. 15. № S3. С. 68-69.
  4. S.O. Kuranov, O.A. Luzina, N.F. Salakhutdinov
    FFA1 (GPR40) Receptor Agonists Based on Phenylpropanoic Acid as Hypoglycemic Agents: Structure–Activity Relationship
    Russian Journal of Bioorganic Chemistry, 2020, V. 46, N 6, Pp 972-988 doi:10.1134/S1068162020060151, IF=0.682
  5. Conjugates of Bispidine and Monoterpenoids as Ligands of Metal Complex Catalysts for the Henry Reaction/ E. S. Mozhaitsev, K. Y. Ponomarev, O. S. Patrusheva, A. V. Medvedko, A. I. Dalinger, A. D. Rogachev, N. I. Komarova, D. V. Korchagina, E. V. Suslov, K. P. Volcho, N. F. Salakhutdinov, S. Z. Vatsadze// Russian Journal of Organic Chemistry, 2020, V.56, N 11, Pp 1969-1981 doi:10.1134/S1070428020110123, IF=0.624
  6. E. V. Suslov, E. S. Mozhaytsev, D. V. Korchagina, N.I. Bormotov, O. I. Yarovaya, K. P. Volcho, O. A. Serova,A. P. Agafonov, R. A. Maksyutov, L.N. Shishkinab, N F. Salakhutdinov
    New chemical agents based on adamantane–monoterpene conjugates against orthopoxvirus infections
    RSC Medicinal Chemistry, 2020, V. 11, N. 10, Pp 1185-1195 doi:10.1039/D0MD00108B
  7. Yu.S. Demidova, E.S. Mozhaitsev, E.V. Suslov, A.A. Nefedov, A.A. Saraeva, K.P. Volcho, N.F. Salakhutdinov, A. Simakov, I.L. Simakova, D.Yu. Murzin
    Menthylamine synthesis via gold-catalyzed hydrogenation of menthone oxime
    Applied Catalysis A: General, 2020, V. 605, 117799 doi:10.1016/j.apcata.2020.117799, IF=5.6
  8. A.O. Zaykovskaya, N. Kumar, E.A. Kholkina, N.S. Li-Zhulanov, P. Maki-Arvela, A. Aho, J. Peltonen, M. Peurla, I. Heinma, B.T. Kusema, S. Streiff, D.Yu. Murzi
    Synthesis and physico-chemical characterization of Beta zeolite catalysts: Evaluation of catalytic properties in Prins cyclization of (–)-isopulegol
    Microporous and Mesoporous Materials, 2020, V. 302, 110236 doi:10.1016/j.micromeso.2020.110236, IF=4.157
  9. I.V. Il'ina, N.S. Dyrkheeva, A.L. Zakharenko, A.Yu. Sidorenko, N.S. Li-Zhulanov, D.V. Korchagina, R. Chand, D.M. Ayine-Tora, A.A. Chepanova, O.D. Zakharova, E.S. Ilina, J. Reynisson, A.A. Malakhova, S.P. Medvedev, S.M. Zakian, K.P. Volcho, N.F. Salakhutdinov, O.I. Lavrik
    Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1
    Molecules 2020, 25(15), 3496 doi:10.3390/molecules25153496, IF=3.267
  10. A.Yu. Sidorenko, A.V. Kravtsova, P. Maki-Arvela, A. Aho, T. Sandberg, I.V. Il'ina, N.S. Li-Zhulanov, D.V. Korchagina, K.P. Volcho, N.F. Salakhutdinov, D.Yu. Murzin, V.E. Agabekov
    Synthesis of isobenzofuran derivatives from renewable 2-carene over halloysite nanotubes
    Molecular Catalysis, 2020, V. 490, 110974 doi:10.1016/j.mcat.2020.110974, IF=3.687
  11. N.S. Li-Zhulanov, A.V. Pavlova, D.V. Korchagina, Yu.V. Gatilov, K.P. Volcho, T.G. Tolstikova, N.F. Salakhutdinov
    Synthesis of 1,3-Oxazine Derivatives Based on (-)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity
    Chemistry of Heterocyclic Compounds, 2020, V. 56, N 7, Pp 936-941 doi:10.1007/s10593-020-02753-x, IF=1.519
  12. O.I. Brusentseva, Yu.V. Kharitonov, M.P. Dolgikh, T.G. Tolstikova, E.E. Shul'ts
    Synthesis and Analgesic Activity Assessment of Furanolabdanoid Conjugates with Glucuronic Acid
    Chemistry of Natural Compounds, 2020, V. 56, N 4, Pp 678-687 doi:10.1007/s10600-020-03119-7, IF=0.653
  13. S.O. Kuranov, O.A. Luzina, O. Onopchenko, I. Pishel, S. Zozulya, M. Gureev, N.F. Salakhutdinov, M. Krasavin
    Exploring bulky natural and natural-like periphery in the design of p-(benzyloxy)phenylpropionic acid agonists of free fatty acid receptor 1 (GPR40)
    Bioorganic Chemistry Volume 99, June 2020, 103830 doi:10.1016/j.bioorg.2020.103830, IF=4.567
  14. V.V. Chernyshov, O.I. Yarovaya, R.Yu. Peshkov, N.F. Salakhutdinov
    Synthesis of cyclic D-(+)-camphoric acid imides and study of their antiviral activity
    Chemistry of Heterocyclic Compounds, 2020, V. 56, N 6, Pp 763-768 doi:10.1007/s10593-020-02728-y, IF=1.491
  15. A. Sidorenko, N. Li-Zhulanov, P. Mäki-Arvela, T. Sandberg, A. Kravtsova, A. Peixoto, C. Freire, K. Volcho, N. Salakhutdinov, V. Agabekov, D. Murzin
    Stereoselectivity inversion by water addition in the -SO3H catalyzed tandem Prins-Ritter reaction for synthesis of 4-amidotetrahydropyran derivatives
    ChemCatChem, 2020, V. 12, N. 9, Pp 2605- 2609 doi:10.1002/cctc.202000070, IF=4.853
  16. O.I. Brusentzeva, Yu.V. Kharitonov, D.S. Fadeev, E.E. Shults
    Synthesis and spectroscopic studies of furan-bridged polyazamacrocycles through 15,16-bis((prop-2-ynylamino)methyl)labdatriene transformations
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2020, 96, N 3-4, Pp 245-250 doi:10.1007/s10847-019-00965-z, IF=1.56
  17. M. Laluc, P. Maki-Arvela, A.F. Peixoto, N. Li-Zhulanov, T. Sandberg, N.F. Salakhutdinov, K. Volcho, C. Freire, A.Yu. Sidorenko, D.Yu. Murzin
    Catalytic synthesis of bioactive 2H-chromene alcohols from (-)-isopulegol and acetone on sulfonated clays
    Reaction Kinetics, Mechanisms and Catalysis, 2020, V. 129, N 2, Pp 627-644 doi:10.1007/s11144-020-01740-9, IF=1.52
  18. Yu.S. Demidova, E.S. Mozhaitsev, A.A. Munkuev, E.V. Suslov, A.A. Saraev, K.P. Volcho, N.F. Salakhutdinov, I.L. Simakova, D.Yu. Murzin
    Monoterpenoid Oximes Hydrogenation Over Platinum Catalysts
    Topics in Catalysis, 2020, V. 63, N 1-2, pages187-195 doi:10.1007/s11244-020-01234-x, IF=2.406
  19. A.A. Kotlyarova, K.Yu. Ponomarev, E.A. Morozova, D.V. Korchagina, E.V. Suslov, A.V. Pavlova, T.G. Tolstikova, K.P. Volcho, N.F. Salakhutdinov
    The effect of 3,7-diazabicyclo[3.3.1]nonanes containing monoterpenoid moieties on the physical activity of mice
    Journal of research in pharmacy, 2020, V. 24, N 2, Pp 196-204 doi:10.35333/jrp.2020.136
  20. V.V. Chernyshov, O.I. Yarovaya, D.S. Fadeev, Yu.V. Gatilov, Ya.L. Esaulkova, A.S. Muryleva, K.O. Sinegubova, V.V. Zarubaev, N.F. Salakhutdinov
    Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity
    Molecular Diversity, 2020, V. 24, N 1, Pp 61-67 doi:10.1007/s11030-019-09932-9, IF=2.013
  21. Analytical Control of Impurities and Active Components in (-)-Isopulegol Derivative - Highly Potent Analgesic Agent/ Lastovka A.V, Fadeeva V.P., Il'ina I.V., Salakhutdinov N.F.// Pharmaceutical Chemistry Journal doi:10.1007/s11094-020-02176-0, IF=0.538

2019
  1. Yu.S. Demidova, I.L. Simakova, M. Estrada, S. Beloshapkin, E.V. Suslov, K.P. Volcho, N.F. Salakhutdinov, A. Simakov, D.Yu. Murzin
    One-Pot Myrtenol Amination over Au, Au-Pd and Pd Nanoparticles Supported on Alumina
    Catalysis Letters, 2019, V. 149, N 12, pp 3454-3464 doi:10.1007/s10562-019-02958-6, IF=2.371
  2. V.V. Chernyshov, Y.V. Gatilov, O.I. Yarovaya, I.P. Koskin, S.S. Yarovoy, K.A. Brylev, N.F. Salakhutdinov
    The first example of the stereoselective synthesis and crystal structure of a spirobi­cyclo­quinazolinone based on (–)-fenchone and anthranilamide
    Acta Crystallographica Section C, V. C75, Part 12, Pp 1675-1680 doi:10.1107/S2053229619015766, IF=0.93
  3. A. V.Lastovka,A. D.Rogachev,I. V.Il'ina,A.Kabir,K.P.Volcho,V. P.Fadeeva,A.G.Pokrovsky,N. F.Salakhutdinov,K. G.Furtonc
    Comparison of dried matrix spots and fabric phase sorptive extraction methods for quantitation of highly potent analgesic activity agent (2R,4aR,7R,8aR)-4,7-dimethyl-2-(thiophen-2-yl)octahydro-2H-chromen-4-ol in rat whole blood and plasma using LC–MS/MS
    Journal of Chromatography B, 2019, V. 1132, Art. Number 121813 doi:10.1016/j.jchromb.2019.121813, IF=2.789
  4. N. Li-Zhulanov, P. Maki-Arvela, M. Laluc, A.F. Peixoto, E. Kholkina, T. Sandberg, A. Aho, K. Volcho, N. Salakhutdinov, C. Freire, A.Yu. Sidorenko, D.Yu. Murzin
    Prins cyclization of (-)-isopulegol with benzaldehyde for production of chromenols over organosulfonic clays
    Molecular Catalysis, 2019, V. 478, 110569 doi:10.1016/j.mcat.2019.110569, IF=2.937
  5. Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Based on Monoterpenoids as Potential Agents for Antitumor Therapy/ A.A. Chepanova, N.S. Li-Zhulanov, A.S. Sukhikh, A. Zafar, J. Reynisson, A.L. Zakharenko, O.D. Zakharova, D.V. Korchagina, K.P. Volcho, N.F. Salakhutdinov, O.I. Lavrik// Russian Journal of Bioorganic Chemistry, 2019, Vol. 45, No. 6, pp. 647-655. doi:10.1134/S1068162019060104, IF=0.794
  6. O.V. Ardashov, A.V. Pavlova, A.K. Mahato, Yu. Sidorova, E.A. Morozova, D.V. Korchagina, G.E. Salnikov, A.M. Genaev, O.S. Patrusheva, N. Li-Zhulanov, T.G. Tolstikova, K.P. Volcho, N. Salakhutdinov
    A novel small molecule supports the survival of cultured dopamine neurons and may restore the dopaminergic innervation of the brain in the MPTP mouse model of Parkinson's disease
    ACS Chemical Neuroscience, 2019, V. 10, N 10, Pp 4337-4349 doi:10.1021/acschemneuro.9b00396, IF=3.861
  7. K. Kovaleva, O. Oleshko, E. Mamontova, O. Yarovaya, O. Zakharova, A. Zakharenko, A. Kononova, N. Dyrkheeva, S. Cheresiz, A. Pokrovsky, O. Lavrik, N. Salakhutdinov
    Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells
    Journal of Natural Products, 2019, V. 82, N 9, Pp 2443-2450 doi:10.1021/acs.jnatprod.8b01095, IF=4.256
  8. Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides/ S. O. Kuranov, M. E. Blokhin, S. A. Borisov, M. V. Khvostov, O. A. Luzina, N. F. Salakhutdinov// Russian Journal of Bioorganic Chemistry, 2019, V. 45, N 5, pp 374-380 doi:10.1134/S1068162019050078, IF=0.794
  9. K. Volcho, A. Zakharenko, O. Luzina, T. Khomenko, E. Suslov, O. Salomatina, O. Zakharova, N. Li-Zhulanov, J. Reynisson, O. Lavrik, N. Salakhutdinov
    Tdp1 Inhibition as a Promising Approach to New Anticancer Drugs
    Proceedings 2019, 22(1), 35 (This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium-Challenges in Drug Discovery Barcelona, Spain | 15-17 May 2019) doi:10.3390/proceedings2019022035
  10. A.A. Chepanova, E.S. Mozhaitsev, A.A. Munkuev, E.V. Suslov, D.V. Korchagina, O.D. Zakharova, A.L. Zakharenko, J. Patel, D.M. Ayine-Tora, J. Reynisson, I.K. H. Leung, K.P. Volcho, N.F. Salakhutdinov, O.I. Lavrik
    The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges
    Applied Sciences, 2019, 9(13), 2767 doi:10.3390/app9132767, IF=2.217
  11. Synthesis, hypolipidemic and antifungal activity of tetrahydroberberrubine sulfonates/ I. V. Nechepurenko, E. D. Shirokova, M. V. Khvostov, T. S. Frolova, O. I. Sinitsyna, A. M. Maksimov, R. A. Bredikhin, N. I. Komarova, D. S. Fadeev, O. A. Luzina, T. G. Tolstikova, N. F. Salakhutdinova// Russian Chemical Bulletin, 2019, V. 68, N 5, pp 1052-1060 doi:10.1007/s11172-019-2519-y, IF=1.014
  12. E.Mozhaitsev,E.Suslov,Yu. Demidova,D. Korchagina,K.Volcho,A. Zakharenko,I. Vasi'eva,M.Kupryushkin,A. Chepanova,D. M. Ayine-Tora,J.Reynisson,N. Salakhutdinov,O. Lavrik
    The Development of Tyrosyl-DNA Phosphodyesterase 1 (TDP1) Inhibitors Based on the Amines Combining Aromatic/Heteroaromatic and Monoterpenoid Moieties
    Letters in Drug Design & Discovery, 2019, V. 6, N 5, Pp 597-605 doi:10.2174/1570180816666181220121042, IF=0.953
  13. E.S. Mozhaitsev, A.L. Zakharenko, E.V. Suslov, D.V. Korchagina, O.D. Zakharova, I.A. Vasil’eva, A.A. Chepanova, E. Black, J. Patel, R. Chand, J. Reynisson, I.K. H. Leung, K.P. Volcho, N.F. Salakhutdinov, O.I. Lavrik
    Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments
    Anti-Cancer Agents in Medicinal Chemistry, 2019, V. 19 , N 4 , Pp 463-472 doi:10.2174/1871520619666181207094243, IF=2.18
  14. N.S. Li-Zhulanov, I.V. Il’ina, A. Chicca, P. Schenker, O.S. Patrusheva, E.V. Nazimova, D.V. Korchagina, M. Krasavin, K.P. Volcho, N.F. Salakhutdinov
    Effect of chiral polyhydrochromenes on cannabinoid system
    Medicinal Chemistry Research, 2019, V. 28, N 4, pp 450-464 doi:10.1007/s00044-019-02294-9, IF=1.72
  15. Synthesis of diazaadamantanes from 1,5-dimethylbispidinone and some natural ketones/ Suslov E.V.1, Ponomarev K. Yu.1, Korchagina D.V.1, Volcho K.P.1,2, Salakhutdinov N.F.// Russian Chemical Bulletin, 2019, V. 68, N 3, pp 601-605 doi:10.1007/s11172-019-2461-z, IF=1.014
  16. N. Dyrkheeva, O. Luzina, A. Filimonov, O. Zakharova, E. Ilina, A. Zakharenko, M. Kuprushkin, D. Nilov, I. Gushchina, V. Svedas, N. Salakhutdinov, O. Lavrik
    Inhibitory Effect of New Semisynthetic Usnic Acid Derivatives on Human Tyrosyl-DNA Phosphodiesterase 1
    Planta Medica, 2019, V. 85, N 2, Pp 103-111 doi:10.1055/a-0681-7069, IF=2.746



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