Department of Medicinal Chemistry
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Head - Doctor of Chemical Sciences, Professor Shults Elvira Eduardovna Phone: 8(383)330-85-33, internal phone: 2-35 email:This email address is being protected from spambots. You need JavaScript enabled to view it. |
The laboratory was founded in 2004 in the staff of Department of Chemistry of Natural and Biologically Active Compounds.
- Resercher ares
The major scientific trends
- Investigation of chemical composition of several plants of Apiaceae, Asteraceae and Fabaceae family as the goal for investigation of sources of sesquiterpene lactones, coumarins and saponines.
- Chemistry of plant alkaloids, development of methods of synthesis and functionalization of isoquinoline, pyridine, diterpenoid and norditerpenoid alkaloids, investigation of their transition metal-catalyzed transformations.
- Palladium catalyzed elaboration of coumarins and their derivatives, synthesis of heterocyclic analogs of combretastatins.
- Development of new synthetic transformations of sesquiterpene lactones and high terpenoids. Synthesis of nitrogen containing heterocyclic compounds• in the labdane, lupane and abietane series. Pd-catalyzed cross-coupling reaction of methylene lactones with aryl halides, 5-bromouracil and iodouridine derivatives.
- Development and production of new agents for treatment of particularly dangerous diseases.
Scientific achievements
- Original methods for isolation of practically important compounds - lappaconitine, elatine, isoalantolactone, peucedanin, peoniflorine, lambertianic acid, pinusolide, flomisoic acid and quinopimaric acid from renewable resources have been development.
- Directed synthetic transformations of plant terpenoids (furan-type labdanoids, levopimaric acid, betulin and betulonic acids), coumarins and alkaloids are carried out.
- Some regularities in the Diels-Alder reaction of diterpenoids – levopimaric and lamdertianic acids and their esters have been carried out. Original approaches to the heterocyclic compounds containing perhydronaphtho[1,2-h]quinazoline and hexahydro-3,6-mathanoindole structural fragments by selective transformations of abietan-type diterpenoids are proposed. Heterocyclic labdanoids of new structural types, with indole, isoindolone, carboline, 3-terpenyl-substituted pyrrol-2(5H)-one, N-substituted maleimides moities, as well as compounds of 8,12-epoxylabdanoid srtuctures have been developed by explored the furan ring selective oxidative methods, selective cycloaddition reactions and intramolecular Diels-Alder approach. The oxidative Heck reaction and Gold-catalyzed reactions, allowing to carry out the specific transformations furanoditerpenoids have been studying. The first synthesis of acetylenic derivatives of labdane type diterpenoids lending to the development of a new series of biohybrids have been achieved.
- Original synthetic approached to aryl substituted polyhydroxynaphtho- and anthraquinones, included compounds with diterpenoid structures were developed. These compounds were characterized as a novel group of selective inhibitors of human immunodeficiency virus reverse transcriptase; the moderate toxicity encouraged the further design of therapeutically relevant compounds. A new group of selective inhibitors of human immunodeficiency virus integrase (inhibited both 3?-processing and strand transfer reactions catalyzed by IN) – derivatives of 3-(furan-2-yl)spiro[5,5]undecane-1,5,9-trione type.
- 1-Substituted derivatives of dihydrothebainehydroquinone are obtained and the possibility of their use in the synthesis of hybrid structures with different cores present in natural products was established. Several approaches to the selective introduction of indolizine fragment into the anthanylate moiety of lappaconitine and N-desacetyllappaconitine have been developed A method of the chemical modification of the structure of the available sesquiterpene ?-methylidene-?-lactone isoalantolactone by means of palladium-catalyzed reaction with versatile aryl halides is developed.
- Derivatives of eudesmane type ?-methylidene-?-lactones, containing aromatic or heterocyclic substituents in the position C(13) were synthesized.
- New methods for preparation of 3-alkenylfurocoumarins, 3-aryl(hetaryl)furocoumarins by the cross-coupling reaction of oreoselones triflate with various vinyl substituted compounds or boronic acids has been proposed. A series of heterocyclic analogues of combretastatine A-4 containing a furocoumarin-modified A- or B-ring are obtained.
Collaboration with:
- Pacific Institute of Bioorganic Chemistry Far-East Branch of Russian Academy of Science;
- Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus;
- Buryat State University;
- Institute of Problems of Chemical and Energetic Technologies Siberian Branch of RAS;
- JSC International research and Production holding “Phytochemistry” (Karaganda, Kazakhstan);
- Institute of Chemistry and Chemical Technology Mongolian Academy of Sciences;
- Institute of Organic Chemistry, University of Cologne (Kцln, Germany);
- Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, USA.
The major scientific trends of current researches
- 5.6. Химические проблемы создания фармакологически активных веществ нового поколения.
- V.48. Фундаментальные физико-химические исследования механизмов физиологических процессов и создание на их основе фармакологических веществ и лекарственных форм для лечения и профилактики социально значимых заболеваний.
Grants of 2012 year
- Grant of RFBR No. 11-03-00242-а
Direct transition metal-catalyzed transformations of isoquinoline alkaloids, labdanoids, sesquiterpenoids and furocoumarins. New lead compounds from plant metabolites. - Grant of RFBR No. 12-03-00535
Creation of perspective biologically active molecules for medicinal applications by synthetic modification of accessible plant metabolites. - Grant of RFBR No. 12-03-92200
Renewable resources for development and production of new agents for treatment of particularly dangerous diseases. Directed Synthetic Transformations of plant alkaloids, sesquiterpenoids and phenolic compounds from Siberian and Mongolian Flora. - Grant of RFBR No. 12-03-90838-young_RF_sр
Investigation and isolation of plant metabolites from plants of Apiaceae family as a target for development of biologically active compounds with tasked properties. Scientific project of Taraskin Vasilii Vladimirovich from Buryat State University in Novosibirsk Institute of Organic Chemistry. - Grant of RFBR No.12-03-31096
Direct transformations of coumarins by Pd- and Cu-catalyzed reactions. - Interdisciplinary joint project SB RAS and Far-East Branch of RAS No 51.
Investigation of metabolites from sea and plant origin as a base for design of important medicinal preparations. - Joint project SB RAS and JSC International research and Production holding “Phytochemistry” No. 108.
Investigation of chemical modifications of available plant metabolites of Kazakhstan and Siberian flora. Searching of new agents for drugs development - Joint project SB RAS and Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus No 23.
Synthetic transformations of pentacyclic triterpenoids as a convenient way for discovering of perspective pharmacologically useful agents. - Project of RAS No FSM-44.
“Direct synthetic transformations of labdane-type diterpenoids for development of new analgesics with selectivity of actions”. - Project of RAS No 5.9.2.
“Direct synthetic transformations of low-molecular plant metabolites and their derivatives. New lead-compounds and sources for treatment of particularly dangerous diseases”.
Research papers(Last& Main)
- Ю.В. Харитонов, Э.Э. Шульц, М.М. Шакиров, И.Ю. Багрянская, Г.А. Толстиков. Синтетические трансформации высших терпеноидов. XXIX. Катализируемая золотом циклоизомеризация пропаргиламинометил- и пропаргилоксиметилзамещенных фуранолабданоидов. Журнал органической химии. 2012. Т. 48. Вып. 8. C. 1085-1092.
- М.Е. Миронов, Э.Э. Шульц, М.М. Шакиров, Ю.В. Харитонов, Г.А. Толстиков. Синтетические трансформации высших терпеноидов. XXVIII. Диеновый синтез с участием 16-(триметилсилоксибутадиенил)лабданоидов. Журнал органической химии. 2012. Т. 48. Вып. 6. С. 842–852.
- В.Е. Романов, Э.Э. Шульц, М.М. Шакиров, Г.А. Толстиков. Исследование алкалоидов флоры Сибири и Алтая. XVIII. 2-Ацетамидо-5-[2-(пиридил-3-ил)винил]бензоаты в синтезе индолизинов антранилатного типа. Журнал органической химии. – 2011. Т. 47. Вып. 4. C. 578-585 (p. 581-588).
- А.В. Липеева, Э.Э. Шульц, М.М. Шакиров, Г.А. Толстиков. Исследование растительных кумаринов. 7. Аминирование трифлата ореозелона. Журнал органической химии. 2011. Т. 47. Вып. 9. C.1367-1379.
- А.В. Беловодский, Э.Э. Шульц, М.М. Шакиров, И.Ю. Багрянская, Ю.В. Гатилов, Г.А. Толстиков. Синтетические трансформации метиленлактонов эудесманового типа. Поведение изоалантолактона в условиях реакции Хека. Журнал органической химии. 2010. Т. 46. Вып. 11. C. 1710-1724.
- Э.Э. Шульц, Д.С. Олейников, И.В. Нечепуренко, M.М. Шакиров, Г.А. Толстиков. Синтетические трансформации высших терпеноидов. XVIII. Cинтез оптически активных производных 9,10-антрахинона. ЖОрХ. 2009. Т. 45. Вып. 1. C. 102-114.
- В.Т. Бауман, Э.Э. Шульц, M.М. Шакиров, Г.А. Толстиков. Синтетические трансформации изохинолиновых алкалоидов. Синтез новых производных дигидротебаингидрохинона. Изв. АН. Сер. хим., 2007, 1206.
- E.E. Shults, E.A. Semenova, A.A. Johnson, S.P. Bondarenko, I.Y. Bagryanskaya, Y.V. Gatilov , G.A. Tolstikov, Y. Pommier. Synthesis and HIV-1 Integrase Inhibitory Activity of Spiroundecane(ene) Derivatives. Bioorg. Med. Chem. Lett., 2007, 17, 1362.
- С.А. Осадчий, Э.Э. Шульц, Е.В. Полухина, М.M. Шакиров, Г.А. Толстиков. Исследование алкалоидов флоры Сибири и Алтая. Сообщение 12. Синтез новых производных лаппаконитина, содержащих олефиновые заместители. Известия АН. Серия химическая. 2006. № 6. 1038-1044.
- E.E. Shults, J. Velder, H.-G. Schmalz, S.V. Chernov, T.V. Rubalova, Y.V. Gatilov, G. Henze, G.A. Tolstikov and A. Prokop. Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential. Bioorg. Med. Chem. Lett., 2006, 16, 4228.
- STAFF
Staff
- PUBLICATIONS
Publications over the past years
Laboratory staff publications (DB NIOCh)
Reviews, Articles
2021- S.S. Patrushev, L.G. Burova, A.A. Shtro, T.V. Rybalova, D.S. Baev, I.V. Shirokikh, A.N. Evstropov, E.E. Shults
Modifications of Isoalantolactone Leading to Effective Antibacterial and Antiviral Compounds
Letters in Drug Design & Discovery (E-pub Ahead of Print) doi:10.2174/1570180817999201211193151, IF=1
2020- M.A. Gromova, Yu.V. Kharitonov, T.V. Rybalova, E.E. Shults
Synthetic studies on tricyclic diterpenoids: convenient synthesis of 16-arylisopimaranes
Monatshefte fur Chemie - Chemical Monthly, , 2020, V. 151, N 12, Pp. 1817 - 1827 doi:10.1007/s00706-020-02713-3, IF=1.348 - Bioactive Components in Methyl tert-Butyl Ether Extract of Sea Buckthorn (Hippophae rhamnoides L.) Green Waste/ T. P. Kukina, D. N. Shcherbakov, K. V. Gensh, N. V. Panteleyeva, Ye. A. Tulysheva, O. I. Sal’nikova, A. Ye. Grazhdannikov, P. V. Kolosov, G. Yu. Galitsyn// Russian Journal of Bioorganic Chemistry, 2020, V. 46, N 7, Pp 1372-1377 doi:10.1134/S1068162020070067, IF=0.681
- Bioactive Components in Methyl tert-Butyl Ether Extract of Sea Buckthorn (Hippophae rhamnoides L.) Green Waste/ T. P. Kukina, D. N. Shcherbakov, K. V. Gensh, N. V. Panteleyeva, Ye. A. Tulysheva, O. I. Sal’nikova, A. Ye. Grazhdannikov, P. V. Kolosov, G. Yu. Galitsyn// Russian Journal of Bioorganic Chemistry, 2020, V. 46, N 7, Pp 1372-1377 doi:10.1134/S1068162020070067, IF=0.681
- K.P. Cheremnykh, V.A. Savelyev, S.A. Borisov, I.D. Ivanov, D.S. Baev, T.G. Tolstikova, V.A. Vavilin, E.E. Shults
Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency
Molecules 2020, 25(23), 5578 doi:10.3390/molecules25235578, IF=3.266 - B.M. Urbagarova, E.E. Shults, V.V. Taraskin, L.D. Radnaeva, T.N. Petrova, T.V. Rybalova, T.S. Frolova, A.G. Pokrovskii, Ja. Ganbaatar
Chromones and coumarins from Saposhnikovia divaricata (Turcz.) Schischk. Growing in Buryatia and Mongolia and their cytotoxicity
Journal of Ethnopharmacology, 2020, V. 261, 1125170 doi:10.1016/j.jep.2019.112517, IF=3.69 - S.A. Popov, M.D. Semenova, D.S. Baev, T.S. Frolova, M.A. Shestopalov, Ch. Wang, Zh. Qi, E.E. Shults, M. Turks
Synthesis and cytotoxicity of hybrids of 1,3,4- or 1,2,5-oxadiazoles tethered from ursane and lupane core with 1,2,3-triazole
Steroids, 2020, V. 162, , 108698 doi:10.1016/j.steroids.2020.108698, IF=1.948 - S.A. Popov, M. D. Semenova, D. S. Baev, T. S. Frolova, E. E.Shults,Ch.Wang, M.Turks
Synthesis of cytotoxic urs-12-ene- and 28-nor-urs-12-ene- type conjugates with amino- and mercapto-1,3,4-oxadiazoles and mercapto-1,2,4-triazoles
Steroids, 2020, V. 153, 108524 doi:10.1016/j.steroids.2019.108524, IF=1.948 - D.V. Reshetnikov, S.S. Patrushev, E.E. Shults
Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers
Chemistry of Natural Compounds, 2020, V. 56, N 5, Pp 855-860 doi:10.1007/s10600-020-03169-x, IF=0.652 - А.Н. Евстропов, Л.Г. Бурова, И.В. Широких, Н.С. Сиражетдинова, В.А. Савельев, Э.Э. Шульц
Антибактериальная активность азотсодержащих производных антрахинона в отношении STAPHYLOCOCCUS AUREUS
Проблемы медицинской микологии. 2020. Т. 22. № 3. С. 73. - A.V. Shpatov, T.S. Frolova, S.A. Popov, O.I. Sinitsyna, O.I. Salnikova, G. Zheng, L. Yan, N.V. Sinelnikova, L.M. Pshennikova, A.V. Kochetov
Lipophilic Metabolites from Five-needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity.
Chemistry & Biodiversity, 2020, V.17, N 8, e2000201 doi:10.1002/cbdv.202000201, IF=2.039 - M.A. Gromova, Yu.V. Kharitonov, L.V. Politanskaya, E.V. Tretyakov, E.E. Shults
A facile approach to hybrid compounds containing a tricyclic diterpenoid and fluorine-substituted heterocycles
Journal of Fluorine Chemistry, 2020, V. 236, 109554 doi:10.1016/j.jfluchem.2020.109554, IF=2.332 - A. Amanzhan, P.Zh. Zhanymkhanova, B. Aidanuly, E.E. Shults, A.Z. Turmukhambetov, S.M. Adekenov
Synthesis and structure of hydrazone derivatives of harmine
News of NAS RK. Series of Chemistry and technology, 2020, V. 3, N 441, Pp 88-95 doi:10.32014/2020.2518-1491.48 - Search for biologically active substances of natural origin based on low-polar conifer extracts/ D. V. Pyatrikas, E. L. Gorbyleva, A. V. Fedyaeva, S. S. Zakharova, A. V. Shpatov, S. A. Popov, G. B. Borovskii// Izvestiya Vuzov. Prikladnaya Khimiya i Biotekhnologiya doi:10.21285/2227-2925-2020-10-2-240-250
- O.I. Brusentseva, Yu.V. Kharitonov, M.P. Dolgikh, T.G. Tolstikova, E.E. Shul'ts
Synthesis and Analgesic Activity Assessment of Furanolabdanoid Conjugates with Glucuronic Acid
Chemistry of Natural Compounds, 2020, V. 56, N 4, Pp 678-687 doi:10.1007/s10600-020-03119-7, IF=0.653 - N.S. Sirazhetdinova, V.A. Savelyev, T.S. Frolova, D.S. Baev, L.S. Klimenko, I.V. Chernikov, O.S. Oleshko, T.A. Sarojan, A.G. Pokrovskii, E.E. Shults
1-Hydroxyanthraquinones Containing Aryl Substituents as Potent and Selective Anticancer Agents
Molecules 2020, 25(11), 2547 doi:10.3390/molecules25112547, IF=3.267 - Reduction in Mortality at All Stages of Animal Life and the Ways to Achieve Productive Longevity Using Aurol (p-Tyrosol)/ KRYSIN A. P., SOLOSHENKO V. A. YUSHKOV YU. G.2, DONSHENKO N. A., MERZLYAKOVA O. G.// Chemistry for Sustainable Development, 2020, V. 28, N 2, Pp 166-173 doi:10.15372/CSD2020216
- O.I. Brusentzeva, Yu.V. Kharitonov, D.S. Fadeev, E.E. Shults
Synthesis and spectroscopic studies of furan-bridged polyazamacrocycles through 15,16-bis((prop-2-ynylamino)methyl)labdatriene transformations
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2020, 96, N 3-4, Pp 245-250 doi:10.1007/s10847-019-00965-z, IF=1.56 - Study of Plant Coumarins. 18. Coumarin Conjugates with Lupane Triterpenoidsand 1,2,3-triazoles: Synthesis and Anti-inflammatory Activity/ Lipeeva A. V., Dolgikh М. Р., Tolstikova T. G., Shults E. E// Russian Journal of Bioorganic Chemistry, 2010, V. 46, N 2, Pp125-132 doi:10.1134/S1068162020010161, IF=0.682
- Study of Plant Coumarins. 18. Coumarin Conjugates with Lupane Triterpenoidsand 1,2,3-triazoles: Synthesis and Anti-inflammatory Activity/ Lipeeva A. V., Dolgikh М. Р., Tolstikova T. G., Shults E. E// Russian Journal of Bioorganic Chemistry, 2010, V. 46, N 2, Pp125-132 doi:10.1134/S1068162020010161, IF=0.682
- Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety/ M.E. Mironov, A.I. Poltanovich , T.V., Rybalova, M.P. Dolgikh, T.G. Tolstikova, E.E Shults// Russian Chemical Bulletin, 2020, V. 69, Pp 537–546 doi:10.1007/s11172-020-2795-6, IF=1.061
- M.A. Lenskiy, E.E. Shul'ts, D.V. Korabel'nikov, A.V. Ozhogin, A.N. Novitskiy
Pyrocatechol borates: Synthesis, reaction with formaldehyde, and solvent effect on polycondensation process
Polymer, 2020, V. 183 , 122162 doi:10.1016/j.polymer.2020.122162, IF=4.231 - QUALITY AND QUANTITATIVE COMPOSITION OF SUNFLOWER OIL DEODORIZATION DISTILLATE/ Kukina T.P., Shcherbakov D.N., Panteleyeva N. V., Sal'nikova O. I., Kolosov P.V.// doi:10.14258/jcprm.2020015909
2019- S.A. Kremis, D.S. Baev, A.V. Lipeeva, E.E. Shults, T.G. Tolstikova, O.I. Sinitsyna, A.V. Kochetov, T.S. Frolova
Genotoxic activity of 1,2,3-triazolyl modified furocoumarins and 2,3-dihydrofurocoumarins
Journal of biochemical and molecular toxicology, 2019, V. 33, N 11, e22396 doi:10.1002/jbt.22396, IF=2.965 - M.E. Mironov, O.S. Oleshko, M.A. Pokrovskii, T.V. Rybalova, V.K. Pechurov, A.G. Pokrovskii, S.V. Cheresis, S.V. Mishinov, V.V. Stupak, E.E. Shults
6-(4'-Aryl-1',2',3'-triazolyl)-spirostan-3,5-diols and 6-(4'-Aryl-1',2',3'-triazolyl)-7-hydroxyspirosta-1,4-dien-3-ones: Synthesis and analysis of their cytotoxicity
Steroids, 2019, V. 151, Article's number 108460 doi:10.1016/j.steroids.2019.108460, IF=2.136 - Lipophilic constituents of pedicularis striata pallas и pedicularis flava pallas/ Kukina, T.P., Khan, I.V.// Khimiya Rastitel'nogo Syr'ya, Issue 4, 1 January 2020, Pages 113-118 doi:10.14258/jcprm.2019044952
- A.V. Lipeeva, D.O. Zakharov, Yu.V. Gatilov, M.A. Pokrovskii, A.G. Pokrovskii, E.E. Shults
Design and Synthesis of 3-(N-Substituted)aminocoumarins as Anticancer Agents from 3-Bromopeuruthenicin
ChemistrySelect, 2019, V. 4, N 34, Pp 10197-10201 doi:10.1002/slct.201901377, IF=1.716 - S.A. Popov, M.D. Semenova, D.S. Baev, I.V. Sorokina, N.A. Zhukova, T.S. Frolova, T.G. Tolstikova, E.E. Shults, M. Turks
Lupane-type conjugates with aminoacids, 1,3,4- oxadiazole and 1,2,5-oxadiazole-2-oxide derivatives: synthesis, anti-inflammatory activity and in silico evaluation of target affinity
Steroids, 2019, V.150, 108443 doi:10.1016/j.steroids.2019.108443, IF=2.136 - Synthesis of Polyesters of Diatomic Phenols and Boric Acid and Their Interaction with Formaldehyde/ M. A. Lenskiy, E. E. Shul'ts, D. V. Korabel'nikov, A. V. Ozhogin, A. N. Novitskiy// Polymer Science, Series B, 2019, V. 61, N 5, pp 530-539 doi:10.1134/S1560090419050105, IF=0.907
- V.A. Savel'ev, A.A. Kotova, T.V. Rybalova, E.E. Shults
Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles Containing an Anthranilic Acid Motif
Chemistry of Heterocyclic Compounds, 2019, V. 55, N 10, pp 943-955 doi:10.1007/s10593-019-02561-y, IF=1.492 - Study of Plant Coumarins: XVII. Synthesis and Transformations of 6-Carboxamidocoumarins/ E.E.Shults, D.O. Zakharov, A.V. Lipeeva, Yu.V. Gatilov, A.G. Makarov// Russian Journal of Organic Chemistry, 2019, V. 55, N 10, pp 1518-1526 doi:10.1134/S1070428019100099, IF=0.751
- A.V. Lipeeva, M.M. Shakirov, E.E. Shults
A facile approach to 6-amino-2H-pyrano[2,3-g]isoquinolin-2-ones via a sequential Sonogashira coupling of 6-cyanoumbelliferone triflate and annulations with amines
Synthetic Communications, 2019, V. 49, N 23, Pp 3301-3310 doi:10.1080/00397911.2019.1661480, IF=1.439 - M.A. Gromova, Yu.V. Kharitonov, T.V. Rybalova, E.E. Shul'ts
Synthetic Transformations of Higher Terpenoids. 38.* Synthesis of Conjugates Containing β-Carboline and Tricyclic Diterpenoids
Chemistry of Natural Compounds, 2019, V. 55, N 5, pp 871-877 doi:10.1007/s10600-019-02836-y, IF=0.566 - Aliphatic and triterpenoic products of ether extracts saponification of POPULUS NIGRA L/ T. P. Kukina, I. A. Elshin , O. I. Salnikova , I. V. Eltsov// doi:10.14258/jcprm.2019034951
- Cardioprotective Effect of p-Tyrosol in the Acute Period of Cardiovascular and Cerebral Ischemia/ A.P Krysin, I.V. Sorokina, E.E. Shults// Chemistry for Sustainable Development, 2019, V. 27, N 4, Pp 365-372 (in Russian) doi:10.15372/KhUR2019147
- B.M. Urbagarova, V.V. Taraskin, E.E. Shults, L.D. Radnaeva
Development of assay method by HPLC-DAD for the quantitative determination of chromones in Saposhnikovia divaricata radices and its validation
IOP Conference Series: Earth and Environmental Science, 2019, V. 320, N 1, art. Num. 012056 (Conference Paper) doi:10.1088/1755-1315/320/1/012056 - Synthesis and properties of polyethylene-p-triphenylboron ester of boric acid/ M. A. Lenskiy, E. E. Shul'ts, D. V. Korabel'nikov, A. V. Ozhogin, A. N. Novitskiy,// Izvestiya Vysshikh Uchebnykh Zavedenii, Seriya Khimiya i Khimicheskaya Tekhnologiya, 2019, V. 62, N 7, Pp 31-37 doi:10.6060/ivkkt20196207.5882
- T.S. Frolova, A.V. Lipeeva, D.S. Baev, S.I. Baiborodin, К.E. Orishchenko, A.V. Kochetov, O.I. Sinitsyna
Fluorescent labeling of ursolic acid with FITC for investigation of its cytotoxic activity using confocal microscopy
Bioorganic Chemistry, 2019, V. 87, Pp 876-887 doi:10.1016/j.bioorg.2018.11.052, IF=3.929 - E. Avdeeva, E. Shults, T. Rybalova, Ya. Reshetov, E. Porokhova, I. Sukhodolo, L. Litvinova, V. Shupletsova, O. Khaziakhmatova, I. Khlusov, A. Guryev, M. Belousov
Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro
Biomolecules, 2019, 9(5), 189 doi:10.3390/biom9050189, IF=4.694 - A.V. Lipeeva, A.O. Brysgalov, T.G. Tolstikova, E.E. Shults
Synthesis, Transformations and Characterization of 8 Aminomethyl Substituted Umbelliferones as Probable Anti-Arrhythmic Agents
Current Bioactive Compounds, 2019, V. 15 , N 1, Pp 71-82 Volume 15 , Issue 1 , 2019 doi:10.2174/1573407213666171030152601 - A.V. Lipeeva, D.O. Zakharov, L.G. Burova, T.S. Frolova, D.S. Baev, I.V. Shirokikh, A.N. Evstropov, O.I. Sinitsyna, T.G. Tolsikova, E.E. Shults
Design, Synthesis and Antibacterial Activity of Coumarin-1,2,3-triazole Hybrids Obtained from Natural Furocoumarin Peucedanin
Molecules 2019, 24(11), 2126 doi:10.3390/molecules24112126, IF=3.06 - K.P. Cheremnykh, V.A. Savelyev, M.A. Pokrovskii, D.S. Baev, T.G. Tolstikova, A.G. Pokrovskii, E.E. Shults
Design, synthesis, cytotoxicity, and molecular modeling study of 2,4,6-trisubstituted pyrimidines with anthranilate ester moiety
Medicinal Chemistry Research, 2019, V. 28, N 4, pp 545–558 doi:10.1007/s00044-019-02314-8, IF=1.72 - S.M. Adekenov, P.Zh. Zhanimkhanova, Zh.S. Nurmaganbetov, A. Amanzhan, S.V. Chernov, A.Zh. Turmukhambetov, I.Yu. Bagryanskaya, Yu.V. Gatilov, E.E. Shults
Synthetic modifications of carboline alkaloid harmine: synthesis of 8-substituted derivatives
Chemistry of Heterocyclic Compounds, 2019, V. 55, N 2, pp 135-141 doi:10.1007/s10593-019-02429-1, IF=1.492 - M.A. Gromova, Yu.V. Kharitonov, M.A. Pokrovskii, I.Yu. Bagryanskaya, A.G. Pokrovskii, E.E. Shul'ts
Synthetic Transformations of Higher Terpenoids. 37. Synthesis and Cytotoxicity of 4-(Oxazol-2-Yl)-18-Norisopimaranes
Chemistry of Natural Compounds, 2019, V. 55, N 1, pp 52-59 doi:10.1007/s10600-019-02613-x, IF=0.567 - Bioactive components of ethereal extract of wood greening sea buckthorn Hippophae rhamnoides L./ T.P. Kukina, D.N. Shcherbakov, K.V. Gensh, N.V. Panteleyeva, E. A. Tulysheva, O.I. Sal'nikova, A.Ye. Grazhdannikov, P.V. Kolosov, G.Yu. Galitsyn// Khimiya Rastitel'nogo Syr'ya, 2019, N 1, Pp 157-164 doi:10.14258/jcprm.2019014340
2018- Ch. Tantardini, S.G. Arkipov, K.A. Cherkashina, A.S. Kil'met'ev, E. V.Boldyreva
Synthesis and crystal structure of a meloxicam co-crystal with benzoic acid
Structural Chemistry, 2018, V. 29, N 6, pp 1867-1874 doi:10.1007/s11224-018-1166-5, IF=2.19 - M.A. Gromova, Yu.V. Kharitonov, I.Yu. Bagryanskaya, E.E. Shults
Efficient Synthesis of the N-(buta-2,3-dienyl)carboxamide of Isopimaric Acid and the Potential of This Compound towards Heterocyclic Derivatives of Diterpenoids
ChemistryOpen, 2018, V. 7, N 11, Pp 890-901 doi:10.1002/open.201800205, IF=2.801 - Esthers and polymethylenesthers of pyrocatechine and boric acid - synthesis, structure/ M.A. Lenskiy, E.E. Shul'ts, D.V. Korabel'nikov, A.V. Ozhogin, A.N. Novitskiy// S-SibSB, 2018, N 4 (24), Cc 255-260
- Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments/ K.P. Cheremnykh, V.А. Savel’ev, O.P. Shkurko, Е.E. Shults// Chemistry of Heterocyclic Compounds, 2018, 54(12), 1131-1138 doi:10.1007/s10593-019-02404-w, IF=1.201
- Synthesis and Anti-Inflammatory Activity of Tyrosol and Its Structural Analogs/ A.P. Krysin, T.G. Tolstikova, M.P., E.E. Shul'ts , L.M. Pokrovskii// Pharmaceutical Chemistry Journal, 2019, V. 52, N 11, pp 907-911 doi:10.1007/s11094-019-01924-1, IF=0.679
- М.Д. Соколова, А.Ф. Федорова, М.Л. Давыдова, А.П. Крысин, Э.Э. Шульц, А.Р. Халдеева
Изучение влияния малолетучих и нетоксичных функционализированных фенольных антиоксидантов на физико-механические свойства резин на основе БИКС-18
Каучук и резина. 2018. Т. 77. № 5. С. 320-325. - Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host-C57BL/6 inbred mice/ M.A. Tsyganov, G.B. Vishnivetskaya, T.P. Kukina, I.V. Sorokina, M.N. Lvova, M.A. Protsenko, N.E. Kostina, D.F. Avgustinovich// VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII, , 2018, V. 22, N 7, Pp. 856-864 doi:10.18699/VJ18.426
- А.П. Крысин, А.А. Нефедов, Т.Я. Гаврикова, А.С. Кильметьев
О реакции полисульфидов 2-трет-бутилфенола с каучуком и гептеном-1 в инертной атмосфере и на воздухе
Химия в интересах устойчивого развития. 2018. Т. 26. № 4. С. 403-410. doi:10.15372/KhUR20180407 - Г.М. Байсаров, А.Р. Жуматаева, Г.К. Мукушева, Э.Э. Шульц, Р.Б. Сейдахметова, С.М. Адекенов
Флавоноидные соединения ARTEMISIA GLABELLA KAR. ET KIR, синтезы на их основе и их биологическая активность
Химия растительного сырья. 2018. № 3. С. 215-222. - Y.V. Kharitonov, M.M. Shakirov, E.E. Shults
Highly Selective Gold-Catalyzed Cycloisomerization of Furanolabdanoid Dialkynes with Alkynyl Substituents in the Furan Ring
Current Organic Synthesis. 2018. Vol. 15. No 8. P. 1147-1153 doi:10.2174/1570179415666180918160421, IF=1.69 - И.В. Широких, Л.Г. Бурова, А.B. Липеева, Э.Э. Шульц
Изучение антибактериальных свойств производных пеуцеданина в отношении staphylococcus sureus in vitro
Сибирский медицинский вестник. 2018. № 2. С. 8-12. - А.Н. Евстропов, Л.Г. Бурова, И.В. Широких, А.В. Липеева, Э.Э. Шульц
Иследование антимикробной активности кумариновых субстанций в отношении STAPHYLOCOCCUS AUREUS и PSEUDOMONAS AERUGINOSA
Бактериология. 2018. Т. 3. № 2. С. 16-19. doi:10.20953/2500-1027-2018-2-16-19 - Accessible Metabolites from Siberian Plants for Development and Production of Innovative Drugs/ T.G. Tolstikova, I.V. Sorokina, N.A. Zukova, E.A. Morosova, YU.V. Kharitonov, M.E. Mironov, S.A. Popov, E.E. Shults// doi:10.15372/KhUR20180308
- A.E. Grazhdannikov, L.M. Kornaukhova, V.I. Rodionov, N.A. Pankrushina, E.E. Shults, A.S. Fabiano-Tixier, S.A. Popov, F. Chemat
Selecting a green strategy on extraction of birch bark and isolation of pure betulin using monoterpenes
ACS Sustainable Chem. Eng., , 2018, 6 (5), pp 6281-6288 doi:10.1021/acssuschemeng.8b00086, IF=6.14 - A.O. Finke, M.E. Mironov, A.B. Skorova, E.E. Shults
Copper-catalyzed 1,3-dipolar cycloaddition reaction of spirosolanederived azide for the preparation of modified solasodine alkaloid
Chemistry of Heterocyclic Compounds, 2018, V. 54, N 4, pp 411-416 doi:10.1007/s10593-018-2284-0, IF=1.201 - M.A. Gromova, Yu.V. Kharitonov, T.V. Rybalova, E.E. Shul'ts
Synthetic Transformations of Higher Terpenoids. 36.* Synthesis of 13-(Oxazol-5-Yl)-15,16-Bisnorisopimaranes
Chemistry of Natural Compounds, 2018, V. 54, N 2, pp 293-300 doi:10.1007/s10600-018-2327-x, IF=0.45 - Antiulcerogenic activity of borneol derivatives/ M. S. Borisova, O. I. Yarovaya, M. D. Semenova, T. G. Tolstikova, N. F. Salakhutdinov// Russian Chemical Bulletin, 2018, V. 67, N 3, Pp 558-561 doi:10.1007/s11172-018-2110-y, IF=0.781
- А.П. Крысин, В.П. Фадеева, О.Н. Никуличева, А.А. Нефедов
Решение алгоритма: фенольные антиоксиданты - путь к улучшению механических свойств полимерных материалов
Химия в интересах устойчивого развития. 2018. Т. 26. № 2. С. 149-155 doi:10.15372/KhUR20180205 - A.O. Bryzgalov, T.G. Tolstikova, E.E. Shults, K.O. Petrova
Natural Products as a Source of Antiarrhythmic Drugs
Mini-Reviews in Medicinal Chemistry, 2018, V. 18, N 4, Pp 345 - 362 doi:10.2174/1389557516666161104144815, IF=2.645 - Т.П. Кукина
Пентегова Валентина Алексеевна
Химия растительного сырья, 2018, N 2, Cc 233-234 doi:10.14258/jcprm.2018023919 - E. Avdeeva, E. Shults, M. Skorokhodova, Ya. Reshetov, E. Porokhova, I. Sukhodolo, E. Krasnov, M. Belousov
Flavonol glycosides from Saussurea controversa and Their Efficiency in Experimental Osteomyelitis
Planta Med Int Open, 2018, V. 5, N 1, : e24-e29 doi:10.1055/s-0044-100799
2017- A study of plant coumarins. 16*. Synthesis and transformations of 7-alkynylcoumarins/ A. V. Lipeeva, E. E. Shults// Chemistry of Heterocyclic Compounds 2017, 53(12), pp 1302-1309 doi:10.1007/s10593-018-2210-5, IF=0.893
- A.V. Lipeeva, D.S. Baev, M.P. Dolgikh, T.G. Tolstikova, E.E. Shults
Rapid Access to Oxazine Fused Furocoumarins and in vivo and in silico Studies of theirs Biological Activity
Medicinal Chemistry, 2017, V.13, N 7, Pp 625-632 doi:10.2174/1573406413666170601114527, IF=2.331 - S.A. Popov, O.P. Sheremet, L.M. Kornaukhova, A.E. Grazhdannikov, E.E. Shults
An approach to effective green extraction of triterpenoids from outer birch bark using ethyl acetate with extractant recycle
Industrial Crops and Products, 2017, V.102, Pp 122-132 doi:10.1016/j.indcrop.2017.03.020, IF=3.18 - V.T. Bauman, Ja. Ganbaatar, E.E. Shults
Synthetic transformations of isoquinoline alkaloids: 1-(N-alkyl-1,2,3-triazol-4-yl)-6,18-endo-ethenodihydrothebainehydroquinones and triazolylnaphthohydroquinone-containing benzofuroazocines from thebaine
Chemistry of Heterocyclic Compounds, 2017, V. 53, N 8, pp 913-919 doi:10.1007/s10593-017-2145-2, IF=0.893 - S.S. Patrushev, T.V. Rybalova, I. D. Ivanov, V.A. Vavilin, E.E. Shults
Synthesis of a new class of bisheterocycles via the Heck reaction of eudesmane type methylene lactones with 8-bromoxanthines
Tetrahedron, 2017, V. 73, N 19, Pp 2717-2726 In Press, Accepted Manuscript - Note to users doi:10.1016/j.tet.2017.03.016, IF=2.651 - Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells/ T. S. Frolova, A. V. Lipeeva, D. S. Baev, Y. A. Tsepilov, O. I. Sinitsyna// Molecular Biology, 2017, V. 51, N 5, pp 705-711 doi:10.1134/S0026893317050090, IF=0.799
- Yu.V. Kharitonov, M.M. Shakirov, E.E. Shults
Synthesis of novel labdanoid-based macroheterocycles using click-cycloaddition reaction protocol
Макрогетероциклы. 2017. Т. 10. № 1. С. 117-122. doi:10.6060/mhc160959s - Л.Г. Бурова, И.В. Широких, С.С. Патрушев, Т.Г. Толстикова, Э.Э. Шульц
Взаимосвязь структура-антибактериальная активность в ряду производных изоалантолактона
Фундаментальная и клиническая медицина. 2017. Т. 2. № 1. С. 28-34. - E.E. Shults, M.M. Shakirov, M.A. Pokrovsky, T.N. Petrova, A.G. Pokrovsky, P.G. Gorovoy
Phenolic compounds from Glycyrrhiza pallidiflora Maxim and their cytotoxic activity
Natural Product Research, 2017, V. 31,N 4, Pp 445-452 doi:10.1080/14786419.2016.1188094, IF=1.827 - B.M. Urbagarova, V.V. Taraskin, E.E. Shul'ts, L.D. Radnaeva, O.A. Anenkhonov, Zh. Ganbaatar, N.B. Boldanova
Biologically Active Compounds from the Lipid Fraction of Saposhnikovia divaricata
Chemistry of Natural Compounds, January 2017, V. 53, N 1, pp 138-140 doi:10.1007/s10600-017-1928-0, IF=0.46 - Yu.V. Kharitonov, M.M. Shakirov, M.A. Pokrovskii, A.G. Pokrovskii, E.E. Shul'ts
Synthetic Transformations of Higher Terpenoids. XXXV.* Synthesis and Cytotoxicity of Macroheterocyclic Compounds Based on Lambertianic Acid
Chemistry of Natural Compounds, January 2017, V. 53, N 1, pp 77-82 doi:10.1007/s10600-017-1915-5, IF=0.46 - Synthetic transformations of higher terpenoids: XXXVI. Synthesis of furanolabdanoid glycoconjugates with a 1,2,3-triazole linker/ O.I. Kremenko, Yu.V. Kharitonov, E.E. Shul'ts// Russian Journal of Organic Chemistry, January 2017, V. 53, N 1, pp 35-46 doi:10.1134/S1070428017010079, IF=0.603
2016- C. Tantardini, S.G. Arkhipov, K.A. Cherkashina, A.S. Kil'met'ev, E.V. Boldyreva
Crystal structure of a 2:1 co-crystal of meloxicam with acetylendicarboxylic acid
Acta Crystallographica Section E, CRYSTALLOGRAPHIC COMMUNICATIONS, 2016, Том: 72 Стр.: 1856-1859 doi:10.1107/S2056989016018909 - DOI: 10.2174/1573406412666160129105115/ http://benthamscience.com/journals/medicinal-chemistry/article/138908/// doi:10.2174/1573406412666160129105115 , IF=1.457
- A.S. Kihkentayeva, E.E. Shults, Yu.V. Gatilov, S.S. Patrushev, S. Karim, G.A. Atazhanova, S.M. Adekenov
Synthetic Transformations of Sesquiterpene Lactones 10*. Synthesis of 13-Arylguaianolides
Chemistry of Heterocyclic Compounds, October 2016, V. 52, N 10, pp 788-796 doi:10.1007/s10593-016-1967-7, IF=0.815 - Formation of ω-(4-oxo-1,4-dihydropyridin-2-yl)alkanamides in the Beckmann rearrangement of spiro-fused cycloalkanone oximes/ V. A. Savel'ev, A. Ya. Tikhonov, T. V. Rybalova// Russian Journal of Organic Chemistry, October 2016, Volume 52, Issue 10, pp 1379-1384 doi:10.1134/S1070428016100134, IF=0.759
- Photochemical cyclocondensation of 1-arylthio-2-azidoanthraquinones with phenols/ L. S. Klimenko, S. Sirazhetdinova, V. A. Savel'ev, T. P. Martyanov, D. V. Korchagin// Russian Chemical Bulletin, 2016, V. 65, N 7, pp 1814-1819 doi:10.1007/s11172-016-1515-8, IF=0.578
- M.E. Mironov, I.Yu. Bagryanskaya, E.E. Shults
Synthesis of 3-trimethylsiloxy-1-(furan-3-yl)butadiene and its reactions with dienophiles
Chemistry of Heterocyclic Compounds, , 2016, V. 52, N 6, pp 364-373 doi:10.1007/s10593-016-1897-4, IF=0.814 - Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections/ S. O. Vechkapova, T. A. Zapara, E. A. Morozova, A. L. Proskura, E. E. Schul'ts, T. G. Tolstikova, A. S. Ratushnyak// Bulletin of Experimental Biology and Medicine doi:10.1007/s10517-016-3509-9, IF=0.448
- Yu.V. Kharitonov, M.M. Shakirov, E.E. Shults
Synthesis and spectroscopic studies of chiral macrocyclic furanolabdanoids connected on the 16,17-positions by 1,2,3-triazole rings with methylene or oxamethylene units
Journal of Inclusion Phenomena and Macrocyclic Chemistry, April 2016, V. 84, N 3, pp 197-202 doi:10.1007/s10847-016-0596-1, IF=1.253 - M.E. Mironov, M.A. Pokrovsky, Yu.V. Kharitonov, M.M. Shakirov, A.G. Pokrovsky, E.E. Shults
Furanolabdanoid–based 1,2,4-oxadiazoles: Synthesis and cytotoxic activity
CHEMISTRYSELECT, V. 1, N 3, March 2016, Pp: 417-424 doi:10.1002/slct.201600042 - S.S. Patrushev, M.M. Shakirov, E.E. Shults
Synthetic transformations of sesquiterpene lactones 9.*Synthesis of 13-(pyridinyl)eudesmanolides
Chemistry of Heterocyclic Compounds, 2016, V. 52, N 3, pp 165-171 doi:10.1007/s10593-016-1855-1, IF=0.814 - И.В. Сорокина, Н.А. Жукова, Т.Г. Толстикова, С.А. Попов, Э.Э. Шульц
Бетамид - средство с противоопухолевой активностью, снижающее гепато- и нефротоксические эффекты цитостатической полихимиотерапии
Российский биотерапевтический журнал. 2016. Т. 15. № 1. С. 103-104. - M.A. Timoshenko, Yu.V. Kharitonov, M.M. Shakirov, I.Yu. Bagryanskaya, E.E. Shults
Synthetic Studies on Tricyclic Diterpenoids: Direct Allylic Amination Reaction of Isopimaric Acid Derivatives
ChemistryOPEN, V. 5, N 1, pp 65-70, February 2016 doi:10.1002/open.201500187, IF=3.585
2015- V.E. Romanov, E.E. Shul'ts
Alkaloids of the Flora of Siberia and Altai. XXI.*5'-(1,2,3-Triazolyl)-Substituted Lappaconitine Derivatives
Chemistry of Natural Compounds, November 2015, V. 51, N 6, pp 1142-1146 doi:10.1007/s10600-015-1511-5, IF=0.509 - A.V. Lipeeva, M.A. Pokrovsky, D.S. Baev, M.M. Shakirov, I.Y. Bagryanskaya, T.G. Tolstikova, A.G. Pokrovsky, E.E. Shults
Synthesis of 1H-1,2,3-triazole linked aryl(arylamidomethyl) - dihydrofurocoumarin hybrids and analysis of their cytotoxicity
European Journal of Medicinal Chemistry, V.100, 2015, Pp 119-128 doi:10.1016/j.ejmech.2015.05.016, IF=3.447 - Plant coumarins: XV. Oreoselone in the synthesis of 3-[(Z)-alkenyl]- and 3-(1H-1,2,3-triazol-4-yl)psoralens/ A. V. Lipeeva, E. E. Shul'ts// Russian Journal of Organic Chemistry, July 2015, V. 51, N 7, pp 957-966 doi:10.1134/S1070428015070012X, IF=0.657
- Photochemistry of N-substituted salicylic acid amides/ I. P. Pozdnyakov, N. M. Storozhok , N. P. Medyanik, S. A. Krekov, V. E. Borisenko, A. P. Krysin, V. F. Plyusnin, V. P. Grivin// Russian Chemical Bulletin, 2015, V. 64, N 6, pp 1319-1326 doi:10.1007/s11172-015-1012-5, IF=0.481
- G.K. Mukusheva, P.Zh. Zhanymkhanova, A.Sh. Turysbaeva, M.A. Pokrovskii, M.M. Shakirov, A.G. Pokrovskii, E.E. Shul’ts, S.M. Adekenov
Synthesis and Cytotoxicity of Pinostrobin Hydrazone Derivatives
Chemistry of Natural Compounds, 2015, V. 51, N 3, pp 464-471 doi:10.1007/s10600-015-1316-6, IF=0.509 - Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine/ G. N. Zyuz’kov , V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, A. V. Chaikovskii, E. V. Simanina, T. Yu. Polyakova, M. Yu. Minakova, V. V. Udut, T. G. Tolstikova, E. E. Shul’ts, L. A. Stavrova, Ya. V. Burmina, N. I. Suslov, A. M. Dygai// Bulletin of Experimental Biology and Medicine, September 2015, V. 159, N 5, pp 642-645 doi:10.1007/s10517-015-3036-0, IF=0.358
- Anxiolytic Activity of Diterpene Alkaloid Songorine/ Yu. V. Nesterova , T. N. Povet'eva, N. I. Suslov, E. E. Shults, G. N. Ziuz’kov, S. G. Aksinenko, O. G. Afanas’eva, A. V. Krapivin, T. G. Kharina// Bulletin of Experimental Biology and Medicine, September 2015, V. 159, N 5, pp 620-622 doi:10.1007/s10517-015-3029-z, IF=0.358
- Mechanism of low-molecular alkenes interaction with sulfur-containing spatially hindered phenols under conditions of thermal modification of polymer materials/ A. P. Krysin, L. M. Pokrovskii, A. A. Nefedov, I. K. Shundrina, B. A. Selivanov// Russian Journal of General Chemistry, March 2015, Volume 85, Issue 3, pp 659-666 doi:10.1134/S1070363215030226, IF=0.477
- G. K. Mukusheva, A. V. Lipeeva, P. Zh. Zhanymkhanova, E. E. Shults, Yu. V. Gatilov, M. M. Shakirov, S. M. Adekenov
The flavanone pinostrobin in the synthesis of coumarin-chalcone hybrids with a triazole linker
Chemistry of Heterocyclic Compounds, 2015, V. 51, N 2, pp 146-152 doi:10.1007/s10593-015-1672-y, IF=0.621 - Yu.V. Kharitonov, M.M. Shakirov, E.E. Shults
Synthesis of Macroheterocyclic Compounds with a Furan Bridge Possessing Structural Fragments of 1,2,3-Triazoles and Natural Diterpenoids
MACROHETEROCYCLES, 2015, V. 8, N 1, Pp 81-88 doi:10.6060/mhc141138s, IF=0.942 - Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine/ G. N. Zyuz’kov, V. V. Zhdanov, L. A. Miroshnichenko, E. V. Udut, A. V. Chaikovskii, E. V. Simanina, M. G. Danilets, M. Yu. Minakova, V. V. Udut, T. G. Tolstikova, E. E. Shults, L. A. Stavrova, Ya. V. Burmina, A. M. Dygai// Bulletin of Experimental Biology and Medicine, 2015, V. 159, N 1, pp 58-61 doi:10.1007/s10517-015-2889-6, IF=0.358
2014- Э.Э. Шульц, Ю.В. Харитонов, М.А. Тимошенко, А.В. Липеева
Биологически активные гетероциклические системы и макроциклические соединения на основе селективных превращений производных растительных дитерпеноидов и кумаринов.
Фармацевтический бюллетень. 2015. № 1-2.C.38-49 - Синтез и цитотоксическая активность тритерпеноидов лупанового ряда, содержащих фрагменты 1,3,4-оксадиазолов./ А.Н. Антимонова, Н. И. Петренко, М. М. Шакиров, М.А. Покровский, А.Г. Покровский, Э.Э. Шульц11. А.Н. Антимонова, Н. И. Петренко, М. М. Шакиров, М.А. Покровский, А.Г. Покровский, Э.Э. Шульц// Химия природных соединений. 2014. № 6. С. 883-889. doi:10.1007/s10600-014-1150-2, IF=0.5
- Role of NF-κB/IKK-Dependent Signaling in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine/ G. N. Zyuz’kov, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, A. V. Chaikovskii, E. V. Simanina, M. G. Danilets, M. Yu. Minakova, V. P. Demkin, V. V. Udut, T. G. Tolstikova, E. E. Shults, V. I. Agafonov, A. M. Dygai// Bulletin of Experimental Biology and Medicine, March 2015, V. 158, N 5, pp 624-627 doi:10.1007/s10517-015-2822-z, IF=0.365
- About the Mechanism of Analgesic Activity of Highly Efficient Analgesics of the New Structural Type: in vitro Experiments/ E.A. Morozova, T.A. Zapara, A.S.Ratushnyak, S.O.Vechkapova, T.G. Tolstikova, E.E. Shults// Chemistry for Sustainable Development, 2014. Т. 22. № 3. С. 289-293. (in russian)
- Cинтетические трансформации сесквитерпеновых лактонов. 8. Синтез 13{2-оксофуро[2,3-d]пиримидин-3(2Н)-ил}эвдесманолидов./ C. C. Патрушев, М. М. Шакиров, Т. В. Рыбалова, Э. Э. Шульц// Химия гетероциклических соединений. 2014. № 8. С. 591-601. doi:10.1007/s10593-014-1566-4, IF=0.698
- Синтетические трансформации высших терпеноидов. XXXIV. Получение производных изопимаровой кислоты по карбоксильной функции./ М.А. Тимошенко, А.Б. Аюшеев, Ю.В. Харитонов, М.М. Шакиров, Э.Э. Шульц// Химия природных соединений. 2014. № 4. С. 583-589. doi:10.1007/s10600-014-1050-5, IF=0.5
- Alkaloids of the flora of Siberia and Altai: XX. Synthesis of 5-aryl(hetaryl)-substituted anthranilic acid esters/ V. E. Romanov, G. R. Sabankulova, M. M. Shakirov, E. E. Shul’ts// Russian Journal of Organic Chemistry, 2014, V. 50, N 7, pp 960-972. doi:10.1134/S1070428014070070, IF=0.675
- A. V. Lipeeva, E. E. Shults, M. M. Shakirov, M. A. Pokrovsky, A. G. Pokrovsky
Synthesis and Cytotoxic Activity of a New Group of Heterocyclic Analogues of the Combretastatins
Molecules 2014, 19(6), 7881-7900. doi:10.3390/molecules19067881, IF=2.95 - Синтез 19-(2,6-диметилпиридин-4-ил)-20,29,30-тринорлупанов./ А.Н. Антимонова, Н. И. Петренко, М. М. Шакиров, Э.Э. Шульц// Химия природных соединений. 2014. № 2. C. 268-273. doi:10.1007/s10600-014-0938-4, IF=0.5
- Study of plant coumarins: XIV. Catalytic amination of 7-hydroxycoumarin derivatives/ E. A. Makhneva, A. V. Lipeeva, E. E. Shul’ts// Russian Journal of Organic Chemistry, 2014, V. 50, N 5, pp 662-669. doi:10.1134/S107042801405008X, IF=0.675
- Analgesic Activity of Diterpene Alkaloids from Aconitum Baikalensis/ Yu. V. Nesterova, T. N. Povet’yeva, N. I. Suslov, G. N. Zyuz’kov, S. V. Pushkarskii, S. G. Aksinenko, E. E. Schultz, S. S. Kravtsova, A. V. Krapivin// Bulletin of Experimental Biology and Medicine, August 2014, Volume 157, Issue 4, pp 488-491 doi:10.1007/s10517-014-2598-6, IF=0.365
- Фуранодитерпеноиды лабданового ряда: нахождение в растениях, полный синтез, некоторые превращения и биологическая активность./ Э.Э. Шульц, M.Е. Миронов, Ю.В. Харитонов// Химия Химия природных соединений. 2014. №1, с. 5-22. doi:10.1007/s10600-014-0861-8, IF=0.5
- Oxidative dimerization of 2,6-Di-tert-butyl-4-(2-hydroxyethyl)phenol/ A. P. Krysin, A. M. Genaev, L. M. Pokrovskii, M. M. Shakirov// Russian Journal of Organic Chemistry, 2014, V. 50, N 3, pp 367-370 doi:10.1134/S1070428014030117, IF=0.675
- Э.Э. Шульц, А.С. Кишкентаева, C.C. Патрушев, Г.А. Атажанова, С.М. Адекенов
Модификации cесквитерпеновых лактонов c помощью реакции Хека. Некоторые результаты и перспективы.
Фармацевтический бюллетень. 2014, №1-3, с. 20-28.
2013- Синтетические трансформации высших терпеноидов. Cообщение 33. Получение 15,16-дигидроизопимаровой кислоты и метилдигидроизопимарата и их превращения./ Ю.В. Харитонов, Э.Э. Шульц, М.М. Шакиров,// Химия природных соединений. 2013. № 6. С. 916-923. doi:10.1007/s10600-014-0823-1, IF=0.598
- Synthetic transformations of sesquiterpene lactones: VII. Palladium-catalyzed cross-coupling of isoalantolactone with 5-halouracils/ S. S. Patrushev, M. M. Shakirov, T. V. Rybalova, E. E. Shul’ts// Russian Journal of Organic Chemistry, 2013, V.49, N 12, pp 1783-1797 doi:10.1134/S1070428013120130, IF=0.513
- Синтез 13-арилзамещенных производных сесквитерпенового лактона арголида и их анальгетическая активность/ А.Е. Есенбаева, Э.Э. Шульц, Ю.В. Гатилов, M.М. Шакиров, С.С. Патрушев, Г.А. Атажанова, А.Б. Кенешева, С.М. Адекенов// Химия природных соединений. 2013. № 5. С. 752-757. doi:10.1007/s10600-013-0768-9, IF=0.598
- Hepatoprotective Activity of Betulonic Acid Amides Containing Piperidine or Pyrrolidine Nitroxide Moieties/ I. V. Sorokina, D. S. Baev, N. A. Zhukova, T. G. Tolstikova, A. N. Antimonova, N. I. Petrenko, E. E. Shults, and I. A. Grigor’ev// Russian Journal of Bioorganic Chemistry, 2013, V. 39, N 6, pp. 668–670. doi:10.1134/S1068162013060083, IF=0.523
- A Thermoanalytic Method for the Analysis of Biologically Active Substances using Isobornylphenol Derivatives as an Example/ O. N. Nikulicheva, A. P. Krysin, V. P. Fadeeva, E. A. Krasnov, E. E. Nazmutdinova// Pharmaceutical Chemistry Journal, 2014, V. 47, N 11, pp 616-619. doi:10.1007/s11094-014-1021-y, IF=0.319
- Synthetic transformations of higher terpenoids: XXXII. Synthesis of 16-alkenyl-substituted labdatrienes by oxidative coupling of methyl phlomisoate with alkenes/ Yu. V. Kharitonov, O. I. Kremenko, E. E. Shults, M. M. Shakirov, G. A. Tolstikov// Russian Journal of Organic Chemistry 2013, V.49, N 11, pp 1690-1702 doi:10.1134/S1070428013110225, IF=0.513
- Synthetic transformations of isoquinoline alkaloids. 1-alkynyl-3,6-dimethoxy-N-methyl-4,5α--epoxy-6,18-endoethenobenzo[i]isomorphinans and their transformations/ V. T. Bauman, E. E. Shul’ts, V. V. Kononchuk, I. Yu. Bagryanskaya, M. M. Shakirov, G. A. Tolstikov// Russian Journal of Organic Chemistry, 2013, V.49, N 10, pp 1502-1513. doi:10.1134/S1070428013100175, IF=0.513
- Cинтез и исследование мутагенных свойств тритерпеноидов лупанового ряда, содержащих фрагменты 1,2,3-триазолов в положении С-30/ А.Н. Антимонова, Н.И. Петренко, М.М. Шакиров, Т.В. Рыбалова, Т.С. Фролова, Э.Э. Шульц, Т.П. Кукина, О.И. Синицына, Г. А. Толстиков// Химия природных соединений. 2013. № 4. С. 564-570. doi:10.1007/s10600-013-0702-1, IF=0.598
- Synthetic transformation of higher terpenoids 31. Synthesis of 1,2,3-triazolyl-containing furan labdanoids and studies of their cytotoxic activity/ Yu. V. Kharitonov, E. E. Shul’ts, M. M. Shakirov, M. A. Pokrovskii, A. G. Pokrovskii, G. A. Tolstikov// Russian Chemical Bulletin, 2013, V. 62, N 9, pp 2046-2055. doi:10.1007/s11172-013-0297-5, IF=0.423
- E.E. Shults
Modification of Biologically Active Plant Metabolites Via the Transition Metal Catalyzed Reactions
Eurasian Chemico-Technological Journal, 2013, V. 15, N 3, pp. 175-187. - Исследование растительных кумаринов. XII. Cинтез 2-(1,2,3-триазолил)модифицированных фурокумаринов./ А.В. Липеева, Э.Э. Шульц, Е.А. Махнёва, М.М. Шакиров, Г.А. Толстиков.// Химия гетероциклических соединений. 2012. № 4. С. 591-601. doi:10.1007/s10593-013-1281-6, IF=0.634
- Fabrication of coatings based on epoxy resins for environmental protection of microelectronics/ A. P. Krysin, O. I. Yakovlev// Russian Journal of Applied Chemistry, 2013, V. 86, N 7, pp 997-1000. doi:10.1134/S1070427213070094, IF=0.234
- Synthesis, structure, and antioxidant activity of hybrid N-substituted salicylic acid amides/ N. M. Storozhok, N. P. Medyanik, A. P. Krysin, S. A. Krekov, V. E. Borisenko// Russian Journal of Organic Chemistry, 2013, V.49, N 7, pp 1031-1034 doi:10.1134/S1070428013070129, IF=0.513
- A.O. Bryzgalov, V.E. Romanov, T.G. Tolstikova, E.E. Shults
Lappaconitine: Influence of Halogen Substituent on the Antiarrhythmic Activity
Cardiovascular & Hematological Agents in Medicinal Chemistry., 2013, V. 11 N 3, P. 211 - 217. doi:10.2174/18715257113119990083 - Diels-alder reactions with ethyl 1-benzofuran-3-carboxylates/ A. S. Kil'met'ev, E. E. Shul'ts, M. M. Shakirov, T. V. Rybalova, G. A. Tolstikov// Russian Journal of Organic Chemistry, 2013, V.49, N 6, pp 872-885 doi:10.1134/S1070428013060134, IF=0.513
- Cинтез производных N-арилоксиалкиланабазина./ Н.М. Слынько, Л.Е. Татарова, М.М. Шакиров, Э.Э. Шульц.// Химия природных соединений. 2013. № 2. С. 250-256. doi:10.1007/s10600-013-0585-1, IF=0.598
- New Scientific Directions of the Works of Siberian Scientists in Chemistry of Phenol Antioxidants/ A.P. Krysin// Chemistry for Sustainable Development, 2013, Т. 21,. № 5, pp. 561-572. (in russian).
- Фурокумарины горичника Peucedanum baicalense флоры Монголии и их цитотоксическая активность./ Ж. Ганбаатар, Э.Э. Шульц, Т.Н. Петрова, M.М. Шакиров, Д. Отгонсурен, А.Г. Покровский, Г.А. Толстиков.// Химия природных соединений. 2013. № 1. С. 89-91. doi:10.1007/s10600-013-0518-z, IF=0.598
- Исследование алкалоидов флоры Сибири и Алтая. XIX. Cинтез новых производных лаппаконитина по ароматическому фрагменту./ Романов В.Е., Шульц Э.Э., Шакиров М.М., Толстиков Г.А.// Химия природных соединений. 2013. № 1. С. 58-61. doi:10.1007/s10600-013-0506-3, IF=0.598
- Synthetic transformations of higher triterpenoids. XXX. Synthesis and cytotoxic activity of betulonic acid amides with fragments of nitroxyl radicals/ A. N. Antimonova, N. I. Petrenko, E. E. Shults, Yu. F. Polienko, M. M. Shakirov, I. G. Irtegova, M. A. Pokrovskii, K. M. Sherman, I. A. Grigor’ev, A. G. Pokrovskii, G. A. Tolstikov// Russian Journal of Bioorganic Chemistry, 2013, V. 39, N 2, pp 181-185 doi:10.1134/S1068162013020027, IF=0.523
- Modification of biologically active plant metabolites via the metal complex catalysis reactions as a promising direction in medicinal chemistry/ E. E. Shul’ts, G. A. Tolstikov// Russian Chemical Bulletin, 2013, V. 62, N 3, pp 605-621. doi:10.1007/s11172-013-0083-4, IF=0.423
- Plant coumarins: XIII. Synthesis of 2,3,9-trisubstituted furocoumarins/ A. V. Lipeeva, E. E. Shul’ts, M. M. Shakirov, I. Yu. Bagryanskaya, G. A. Tolstikov// Russian Journal of Organic Chemistry, 2013, V. 49, N 3, Pp: 403-411 doi:10.1134/S1070428013030159, IF=0.513
- Plant coumarins: XI. Cross coupling reactions with 2-(tosyl)oreoselone/ A. B. Lipeeva, E. E. Shul’ts, M. M. Shakirov, G. A. Tolstikov// Russian Journal of Organic Chemistry, 2013, V.49, N 1, Pp 99-107 doi:10.1134/S107042801301017X, IF=0.513
2012- 15,16-Эпокси-3,13(16),14-неоклеродатриен-17,12:18,19-диолид – новое соединение из Galatella punctata/ С.М. Адекенов, Э.Э. Шульц, Ю.В. Гатилов, А.А. Ломзов, Г.А. Атажанова, А.Н. Куприянов// Хим. Природ. Соедин., 2012, № 6, 841-843. doi:10.1007/s10600-013-0435-1, IF=1.29
- Synthesis of (Z)-styrylfurocoumarins as the heterocyclic analogues of combretastatins/ A.V. Lipeeva, E.E. Shul'ts, M.M. Shakirov, G.A. Tolstikov// DOKL CHEM, 2012, V. 447, Pp. 282-285. doi:10.1134/S0012500812120038 Part: 2, IF=0.314
- Synthesis of Betulin Derivatives: N '{N-[3-OXO-20(29)-Lupen-28-OYL]-9-Aminononanoyl}3-Amino-3-Phenylpropionic Acid/ S.V. Sysolyatin, V.N. Surmachev, V.V. Malykhin, A.I. Kalashnikov, I.A. Surmacheva, E.G. Sonina, A.S. Dubkov, G.A. Tolstikov, E.E. Shul'ts, N.F. Salakhutdinov, U.M. Dzhemilev// PHARM CHEM J+, 2012, V. 46, N 8, pp. 473-477. doi:10.1007/s11094-012-0828-7, IF=0.372
- Synthetic transformations of isoquinoline alkaloids. Synthesis of N '-substituted 1-alkynyl-7 alpha,8 alpha-(2,5-dioxopyrrolidino)-[3,4-h]-6,14-endo-ethenotetrahydrothebaines and their transformations/ V.T. Bauman, E.E. Shults, M.M. Shakirov, G.A. Tolstikov// RUSS J ORG CHEM+, 2012, V.48, N 11, pp. 1473-1483. doi:10.1134/S1070428012110103, IF=0.648
- Synthetic transformations of sesquiterpene lactones 6.* Alantolactone and isoalantolactone derivatives in the Heck reaction/ E. E. Shul'ts, A. V. Belovodskii, M. M. Shakirov, G. A. Tolstikov// RUSS CHEM B+, 2012, V. 61, N 10, pp. 1975-1985. doi:10.1007/s11172-012-0274-4, IF=0.379
- First synthesis of macrocyclic furanolabdanoids via cycloaddition of diacetylenic derivatives of lambertianic acid to 1,5-diazidopentane/ Yu.V. Kharitonov, E.E. Shul'ts, M.M. Shakirov, I.Yu. Bagryanskaya, G.A. Tolstikov// DOKL CHEM, 2012, V. 446, Pp. 174-179. doi:10.1134/S0012500812090042 Part: 1, IF=0.314
- Study of plant coumarins: X. Peurutenicin triflate in cross-coupling reactions/ E.A. Makhneva, A.V. Lipeeva, E.E. Shults, M.M. Shakirov, G.A. Tolstikov// RUSS J ORG CHEM+, 2012, V.48, N 8, pp. 1094-1102. doi:10.1134/S1070428012080106, IF=0.648
- Synthetic transformations of higher terpenoids: XXIX. Gold catalyzed cycloisomerization of propargylaminomethyl substituted and propargyloxymethyl substituted furanolabdanoids/ Yu.V. Kharitonov, E.E. Shults, M.M. Shakirov, I.Yu. Bagryanskaya, G.A. Tolstikov// RUSS J ORG CHEM+, 2012, V.48, N 8, pp. 1081-1089. doi:10.1134/S1070428012080088, IF=0.648
- Synthetic transformations of higher terpenoids: XXVIII. Diels-Alder reactions of 16-(trimethylsiloxybutadienyl) labdanoids/ M.E. Mironov, E.E. Shul'ts, M.M. Shakirov, Yu.V. Kharitonov, G.A. Tolstikov// RUSS J ORG CHEM+, 2012, V.48, N 6, pp. 840-850. doi:10.1134/S1070428012060164, IF=0.648
- E.A. Khatuntseva, V.M. Men’shov, A.S. Shashkov, Y.E. Tsvetkov, R.N. Stepanenko, R.Ya. Vlasenko, E.E. Shults, G.A. Tolstikov, T.G. Tolstikova, D.S. Baev, V.A. Kaledin, N.A. Popova, V.P. Nikolin, P.P. Laktionov, A.V. Cherepanova, T.V. Kulakovskaya, E.V. Kulakovskaya, N.E. Nifantiev
Triterpenoid saponins from the roots of Acanthophyllum gypsophiloides Regel
Beilstein J. Org. Chem., 2012, V. 8, 763-775. doi:10.3762/bjoc.8.87, IF=2.516 - Синтетические трансформации высших терпеноидов. XXVII. Синтез 7-гидроксилабданоидов и их превращения/ Ю.В. Харитонов, Э.Э. Шульц, Ю.В. Гатилов, И.Ю. Багрянская, M.М. Шакиров, Г.А. Толстиков// Хим. Природ. Соедин., 2012, № 2, 225-231. doi:10.1007/s10600-012-0215-3, IF=1.29
- Синтетические трансформации сесквитерпеновых лактонов V. Cинтез и цитотоксическая активность 13-арилзаме-щенных производных турнефорина/ Э.Э. Шульц, С.С. Патрушев, А.В. Беловодский, М.М. Шакиров, Т.В. Рыбалова, А.Г. Покровский, М.А. Покровский, Г.А. Толстиков, С.М. Адекенов// Хим. Природ. Соедин., 2012, № 2, 221-224. doi:10.1007/s10600-012-0214-4, IF=1.29
- Синтетические трансформации сесквитерпеновых лактонов. IV. Cинтез и превращения гемм-дихлорциклопропил-замещенных производных изоалантолактона/ Э.Э. Шульц, А.В. Беловодский, М.М. Шакиров, Ю.В. Гатилов, А.Г. Покровский, М.А. Покровский, Г.А. Толстиков// Хим. Природ. Соедин., 2012, № 2, 215-220. doi:10.1007/s10600-012-0213-5, IF=1.29
- Исследование растительных кумаринов. IX. Фенольные соединения Ferulopsis hystrix bunde (Peucedanum hystrix), произрастающего в Монголии. Цитотоксическая активность 2',3'-дигидрофурокумаринов/ Э.Э. Шульц, Ж. Ганбаатар, Т.Н. Петрова, M.М. Шакиров, И.Ю. Багрянская, В.В. Тараскин, Л.Д. Раднаева, Д. Отгонсурен, А.Г. Покровский, Г.А. Толстиков// Хим. Природ. Соедин., 2012, № 2, 194-199 doi:10.1007/s10600-012-0207-3, IF=1.29
- Study of Skin Anti-Ageing and Anti-Inflammatory Effects of Dihydroquercetin, Natural Triterpenoids, and Their Synthetic Derivatives/ Ch.W. Lee, N.H. Park, J.W. Kim, B.H. Um, A.V. Shpatov, E.E. Shults, I.V. Sorokina, S.A. Popov// RUSS J BIOORG CHEM+, 2012, V. 38, N 3, pp. 328-334. doi:10.1134/S1068162012030028, IF=0.635
- Interrelation between the chemical structure and antioxidant properties of N-substituted amides of salicylic acid/ N. M. Storozhok, N. P. Medyanik, A. P. Krysin, I. P. Pozdnyakov, S. A. Krekov// Kinetics and Catalysis, 2012, V. 53, N 2, pp 162-171. doi:10.1134/S0023158412020115, IF=0.638
- Synthetic Transformations of Higher Terpenoids. XXVI. 16-Acetylaminomethyllabdanoids and Their Cytotoxicity/ Yu.V. Kharitonov, E.E. Shul'ts, M.M. Shakirov, M.A. Pokrovsky, A.G. Pokrovsky, G.A. Tolstikov// RUSS J BIOORG CHEM+, 2012, V. 38, N 1, pp. 107-115. doi:10.1134/S1068162011060082, IF=0.635
- S.S. Patrushev, L.G. Burova, A.A. Shtro, T.V. Rybalova, D.S. Baev, I.V. Shirokikh, A.N. Evstropov, E.E. Shults