Department of Medical Chemistry
Head - Professor, Dr. Sci. Tatiana Genrikhovna Tolstikova
Phone: (383) 330-07-31
internal phone: 2-49
email:This email address is being protected from spambots. You need JavaScript enabled to view it.
The laboratory of pharmacological investigations was founded in 2000. From that moment more than 1000 novel compounds were tested by 60 experimental animal models, among them perspective opioid analgesic, antidepressant, nootropic, anxiolytic, anticonvulsant, muscle relaxant, hepatoprotector, cytostatic toxic effects corrector, antihypertensive, antiarrhythmic, antiulcer, anti-inflammatory, anti- hypercholesterolemia and antioxidant compounds were disclosed. Also compounds for the MR-tomography and nano-aerosol forms of water insoluble drugs were developed.
- Resercher ares
Research areas:
The toxic-pharmacological investigation of low-molecular plant metabolites and their synthetic derivatives with the goal of original medications creation.
Plant metabolites chemistry. Medicinal chemistry. Pharmacological properties and mechanism of action investigation of novel drug agents of natural or synthetic origin.
Pharmacological properties and mechanism of action investigation of novel drug agents derived by clathration with glycosides and polysaccharides.
Cytoprotective and antitumoral agents search among triterpenoids.
In vivo and in vitro investigation of analgesic, psychotropic and cardiotropic agent’s properties.
Pharmacological screening of novel biologically active plant and synthetic compounds.
Main scientific results:
- More than 1500 new compounds were investigated
- More than 250 articles and 5 books were published
- 17 PhD theses and 3 doctoral theses were defended
- Next promising agents were found: “BETAMID”, “GLYCIDIPIN”, “FLUOGLISIN”, “DIOL”, “RNA-sin”, “BISULFAMIN”, “METILAN”, “FURALANIN”.
- STAFF
Staff
- PUBLICATIONS
Publications over the past yearsLaboratory staff publications (DB NIOCh)
Reviews, Articles
2023- D. Pon'kina, S. Kuranov, M. Khvostov, N. Zhukova, Yu. Meshkova, M. Marenina, O. Luzina, T. Tolstikova, N. Salakhutdinov
Hepatoprotective Effect of a New FFAR1 Agonist-N-Alkylated Isobornylamine
Molecules 2023, 28(1), 396; doi:10.3390/molecules28010396, IF=4.927 - A. Bryzgalov, T. Tolstikova, B. Koshcheev, A. Maksimov
Synthesis new fluorinated 4-phenyl-1,4-dihydropyridine derivatives, as perspective antiarrhythmic and antihypertensive drugs
Results in Chemistry, 2023, V.5, January 2023, 100705 doi:10.1016/j.rechem.2022.100705 - Е.С. Щегравина, С.Д. Усова, Д.С. Баев, Е.C. Можайцев, Д.Н. Щербаков, С.В. Беленькая, Е.А. Волосникова, В.Ю. Чиркова, Е.А. Шарлаева, Е.В. Свирщевская, И.П. Фонарева, А.Р. Ситдикова, Н.Ф. Салахутдинов, О.И. Яровая, А.Ю. Федоров
Синтез конъюгатов (aR,7S)-колхицина с монотерпеноидами и изучение их биологиче ской активности
Известия Академии наук. Серия химическая. 2023, № 1, стр. 248, IF=1.703 - А.И. Далингер, Д.С. Баев, О.И. Яровая, В.Ю. Чиркова, Е.А. Шарлаева, С.В. Беленькая, Д.Н. Щербаков, Н.Ф. Салахутдинов, С.З. Вацадзе
Синтез несимметричных амидов N-бензилбиспидинола и изучение их ингибирующей активности по отношению к основной вирусной протеазе SARS-CoV-2
Известия Академии наук. Серия химическая. 2023, № 1, стр. 239, IF=1.703 - D.S. Baev, M.E. Blokhin, V.Yu. Chirkova, S.V. Belenkaya, O.A. Luzina, O.I. Yarovaya, N.F. Salakhutdinov, D.N. Shcherbakov
Triterpenic Acid Amides as Potential Inhibitors of the SARS-CoV-2 Main Protease
Molecules 2023, 28(1), 303 doi:10.3390/molecules28010303, IF=4.927 - M.V. Khvostov, E.D. Gladkova, S.A. Borisov, M.S. Fedotova, N.A. Zhukova, M.K. Marenina, Yu.V. Meshkova, N. Valutsa, O.A. Luzina, T.G. Tolstikova, N.F. Salakhutdinov
9-N-n-alkyl Berberine Derivatives: Hypoglycemic Activity Evaluation
Pharmaceutics 2023, 15(1), 44; doi:10.3390/pharmaceutics15010044, IF=6.525
2022- I.E. Smirnova, E.V. Tret’yakova, D.S. Baev, O.B. Kazakova
Synthetic modifications of abietane diterpene acids to potent antimicrobial agents
Natural Product Research, Published Online: 27 Aug 2021 doi:10.1080/14786419.2021.1969566, IF=2.488 - M. V.Khvostov,N. V.Bulina,N. A.Zhukova,E. G.Morenkov,D. K.Rybin,S. V.Makarova,S. V.Leonov,V.S.Gorodov,V.Yu.Ulianitsky,T.G.Tolstikova
A study on biological properties of titanium implants coated with multisubstituted hydroxyapatite
Ceramics International, 48(23), с. 34780-34792 doi:10.1016/j.ceramint.2022.08.067, IF=5.532 - D.V. Reshetnikov, I.D. Ivanov, D.S. Baev, T.V. Rybalova, E.S. Mozhaitsev, S.S. Patrushev, V.A. Vavilin, T.G. Tolstikova, E.E. Shults
Design, Synthesis and Assay of Novel Methylxanthine–Alkynylmethylamine Derivatives as Acetylcholinesterase Inhibitors
Molecules 2022, 27(24), 8787 doi:10.3390/molecules27248787, IF=4.927 - S. Kuranov, M. Marenina, D. Ivankin, M. Blokhin, S. Borisov, T. Khomenko, O. Luzina, M. Khvostov, K. Volcho, T. Tolstikova, N. Salakhutdinov
The Study of Hypoglycemic Activity of 7-Terpenylcoumarins
Molecules 2022, 27(24), 8663 doi:10.3390/molecules27248663, IF=4.927 - EFFECT OF RHAPONTICUM CARTHAMOIDES AND VACCINIUM OXYCOCCUS MEAL PLANT EXTRACTS COMPOSITION ON PERFORMANCE IN THE MOUSE FORCED SWIM TEST/ Khalikova D.A., An'kov S.V., Meshkova Yu.V., Tolstikova T.G.// Chemistry for Sustainable Development. 2022. Т. 30. № 6. С. 654-659. doi:10.15372/CSD2022428
- SYNTHESIS OF THE NEW DERIVATIVES OF USNIC ACID AND INVESTIGATION OF THEIR HYPOGLYCEMIC PROPERTIES/ Borisov S.A., Luzina O.A., Khvostov M.V., Tolstikova T.G., Salakhutdinov N.F.// Chemistry for Sustainable Development. 2022. Т. 30. № 6. С. 579-584. doi:10.15372/CSD2022420
- A. Kotlyarova, A.V. Podturkina, A.V. Pavlova, D.S. Gorina, A.V. Lastovka, O.V. Ardashov, A.D. Rogachev, A.E. Izyurov, A.B. Arefieva, A.V. Kulikov, T.G. Tolstikova, K.P. Volcho, N.F. Salakhutdinov, Yu. Sidorova
A Newly Identified Monoterpenoid-Based Small Molecule Able to Support the Survival of Primary Cultured Dopamine Neurons and Alleviate MPTP-Induced Toxicity In Vivo
Molecules 2022, 27(23), 8286; doi:10.3390/molecules27238286, IF=4.927 - E.O. Shestakova, S.G. Il'yasov, I.A. Shchurova, V.S. Glukhacheva, D.S. Il'yasov, E.E. Zhukov, A.O. Bryzgalov, T.G. Tolstikova, Yu.V. Gatilov
Investigation of 1,4-Substituted 1,2,3-Triazole Derivatives as Antiarrhythmics: Synthesis, Structure, and Properties
Pharmaceuticals 2022, 15(12), 1443 doi:10.3390/ph15121443, IF=5.215 - Synthesis and analgesic activity of alkyl-substituted octahydro-2H-chromenols/ I. V. Il’ina, D. V. Korchagina, E. A. Morozova, T. G. Tolstikova, K. P. Volcho, N. F. Salakhutdinov// Russian Chemical Bulletin volume 71, pages2482–2488 (2022 doi:10.1007/s11172-022-3677-x, IF=1.703
- M.V. Khvostov, E.D. Gladkova, S.A. Borisov, M.S. Fedotova, N.A. Zhukova, M.K. Marenina, Yu.V. Meshkova, O.A. Luzina, T.G. Tolstikova, N.F. Salakhutdinov
Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives
Int. J. Mol. Sci. 2022, 23(22), 14186 doi:10.3390/ijms232214186, IF=6.208 - N.K. Korbozova, N.O. Kudrina, N.A. Zhukova, A.E. Grazhdannikov, I.V. Blavachinskaya, G.A. Seitimova, T.E. Kulmanov, T.G. Tolstikova, N.V. Terletskaya
Antihypothyroid Effect of Salidroside
Molecules 2022, 27(21), 7487 doi:10.3390/molecules27217487, IF=4.927 - S.V. Valiulin, A.A. Onischuk, A.M. Baklanov, S.N. Dubtsov, G.G. Dultseva, S.V. An'kov, T.G. Tolstikova, S.N. Belogorodtsev, Ya.Sh. Schwartz
Studies of the Specific Activity of Aerosolized Isoniazid against Tuberculosis in a Mouse Model
Antibiotics 2022, 11(11), 1527 doi:10.3390/antibiotics11111527, IF=5.222 - D. Avgustinovich, A. Kizimenko, M. Marenina, M. Lvova, A. Kovner, I. Orlovskaya, L. Toporkova, E. Goiman, M. Tsyganov, D. Ponomarev
Prolonged liver fluke infection combined with alcoholization: An experimental mouse model
Experimental Parasitology, 2022, V. 242, November 2022, 108399 doi:10.1016/j.exppara.2022.108399, IF=2.131 - S.A. Borisov, O.A. Luzina, M.V. Khvostov, T.G. Tolstikova, N.F. Salakhutdinov
Synthesis and Pharmacological Evaluation of (+)-Usnic Acid Derivatives as Hypoglycemic Agents
Molbank 2022, 2022(4), M1459; doi:10.3390/M1459 - A.S. Filimonov, O.I. Yarovaya, A.V. Zaykovskaya, N.B. Rudometova, D.N. Shcherbakov, V.Yu. Chirkova, D.S. Baev, S.S. Borisevich, O.A. Luzina, O.V. Pyankov, R.A. Maksyutov, N.F. Salakhutdinov
(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses
Viruses 2022, 14(10), 2154 doi:10.3390/v14102154, IF=5.817 - S. V. Valiulin, A. A. Onischuk, A. M. Baklanov, S. V. An’kov, S. N. Dubtsov, A A. Alekseev, N. N. Shkil, E V. Nefedova, M. E. Plokhotnichenko, T. G. Tolstikova, A M. Dolgov, G G. Dultseva
Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome
Antibiotics 2022, 11(10), 1305; doi:10.3390/antibiotics11101305, IF=5.222 - A. O. Finke, A. V. Pavlova, E. A. Morozova, T. G. Tolstikova, E. E. Shults
Synthesis of 1,2,3-Triazolyl-Substituted Derivatives of the Alkaloids Sinomenine and Tetrahydrothebaine on Ring A and Their Analgesic Activity
Chemistry of Natural Compounds, 2022, V. 58, N 5. Pp 895-902 doi:10.1007/s10600-022-03824-5, IF=0.83 - D.F. Avgustinovich, M.V. Tenditnik, N.P. Bondar, M.K. Marenina, S.Ya. Zhanaeva, M.N. Lvova, A.V. Katokhin, K.S. Pavlov, V.I. Evseenko, T.G. Tolstikova
Behavioral effects and inflammatory markers in the brain and periphery after repeated social defeat stress burdened by Opisthorchis felineus infection in mice
Physiology & Behavior, 2022, V. 252, 113846 doi:10.1016/j.physbeh.2022.113846, IF=3.742 - M.D. Semenova, S.A. Popov, I.V. Sorokina, Yu.V. Meshkova, D.S. Baev, T.G. Tolstikova, E.E. Shults
Conjugates of Lupane Triterpenoids with Arylpyrimidines: Synthesis and Anti-inflammatory Activity
Steroids, 2022, V. 184, 109042 doi:10.1016/j.steroids.2022.109042, IF=2.76 - Modeling of benign prostatic hyperplasia in rats with a high dose of testosterone/ I. V. Sorokina, N.A. Zhukova, Yu.V. Meshkova, D.S. Baev, T.G. Tolstikova, M.A. Bakarev, E. L. Lushnikova// Bulletin of Experimental Biology and Medicine, 2022, doi:10.47056/0365-9615-2022-173-5-656-663 doi:10.1007/s10517-022-05613-0, IF=0.737
- E. Pashkina, V. Evseenko, N. Dumchenko, M. Zelikman, A. Aktanova, M. Bykova, M. Khvostov, A. Dushkin, V. Kozlov
Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy
Nanomaterials 2022, 12(1), 148 doi:10.3390/nano12010148, IF=5.719 - D. Shcherbakov, D. Baev, M. Kalinin, A. Dalinger, V. Chirkova, S. Belenkaya, A. Khvostov, D. Krut'ko, A. Medved'ko, E. Volosnikova, E. Sharlaeva, D. Shanshin, T. Tolstikova, O. Yarovaya, R. Maksyutov, N. Salakhutdinov, S. Vatsadze
Design and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors
ACS Medicinal Chemistry Letters, 2022, 13, 1, 140-147 (Front Page) doi:10.1021/acsmedchemlett.1c00299, IF=4.632 - M.E. Mironov, S.A. Borisov, T.V. Rybalova, D.S. Baev, T.G. Tolstikova, E.E. Shults
Synthesis of Anti-Inflammatory Spirostene-Pyrazole Conjugates by a Consecutive Multicomponent Reaction of Diosgenin with Oxalyl Chloride, Arylalkynes and Hydrazines or Hydrazones
Molecules 2022, 27(1), 162 doi:10.3390/molecules27010162, IF=4.927 - M.A. Gromova, Yu.V. Kharitonov, S.A. Borisov, T.V. Rybalova, T.G. Tolstikova, E.E. Shul'ts
Synthetic Transformations of Higher Terpenoids. 41. Synthesis and Anti-Inflammatory Activity of 4-(Carboxyalkyl)-18-nor-isopimara-7,15-Dienes
Chemistry of Natural Compounds 2022, 58(1), Pp. 55-64 doi:10.1007/s10600-022-03596-y, IF=0.83
2021- M.V. Khvostov, E.D. Gladkova, S.A. Borisov, N.A. Zhukova, M.K. Marenina, Yu.V. Meshkova, O.A. Luzina, T.G. Tolstikova, N.F. Salakhutdinov
Discovery of the First in Class 9-N-Berberine Derivative as Hypoglycemic Agent with Extra-Strong Action
Pharmaceutics 2021, 13(12), 2138 doi:10.3390/pharmaceutics13122138, IF=6.321 - Ddesign, synthesis, and anti-ulcer activity of new 1-thia-4,8-diazaspiro[4.5]decan-3-one derivatives/ Ivankin D. I., Borisova M. S., Sokolov D. N., Luzina O. A., Tolstikova T. G., Salakhutdinov N. F.// Pharmaceutical Chemistry Journal, 2021, V.55, N 9, Pp doi:30906/0023-1134-2021-55-12-22-26, IF=0.837
- S.F. Vasilevsky, O.L. Krivenko, I.V. Sorokina, D.S. Baev, T.G. Tolstikova, I.V. Alabugin
Cascade Transformations of 1-R-Ethynyl-9,10-anthraquinones with Amidines: Expanding Access to Isoaporphinoid Alkaloids
Molecules 2021, 26(22), 6883 doi:10.3390/molecules26226883, IF=4.411 - Д.А. Халикова, С.В. Аньков, Ю.В. Мешкова, Т.Г. Толстикова
Анаболическая активность растительной композиции экстрактов левзеи и шрота клюквы
Сибирский научный медицинский журнал. 2021. Т. 41. № 6. С. 45-50. doi:10.18699/SSMJ20210604 - Д.А. Халикова, С.В. Аньков, Ю.В. Мешкова, Т.Г. Толстикова
Влияние композиции экстрактовлевзеи и шрота клюквы на уровень тестостерона у мышей
Медицинский академический журнал. - 2021. - Т 21.- N4. C.67-72. doi:10.17816/MAJ90692 - M.S. Borisova, D.I. Ivankin, D.N. Sokolov, O.A. Luzina, T.V. Rybalova, T.G. Tolstikova, N.F. Salakhutdinov
Synthesis, antiulcerative, and anti-inflammatory activities of new campholenic derivatives-1,3-thiazolidin-4-ones, 1,3-thiazolidine-2,4-diones, and 1,3-thiazinan-4-ones
Chemical Papers, 2021, V. 75, Pp 5503–5514 doi:10.1007/s11696-021-01741-5, IF=2.097 - E.F. Khusnutdinova, A.V. Petrova, A.N. Lobov, O.S. Kukovinets, D.S. Baev, O.B. Kazakova
Synthesis of C17-[5-methyl-1,3]-oxazoles by N-propargylation of triterpenic acids and evaluation of their cytotoxic activity
Natural Product Research (Formerly Natural Product ), 2021, V. 35, N 21, Pp 3850-3858 doi:10.1080/14786419.2020.1744139, IF=2.861 - S.V. Valiulin, A.A. Onischuk, A.M. Baklanov, S.N. Dubtsov, S.V. An'kov, N.N. Shkil, E.V. Nefedova, M.E. Plokhotnichenko, T.G. Tolstikova, A.M. Dolgov, G.G. Dultseva
Aerosol Inhalation Delivery of Cefazolin in Mice: Pharmacokinetic Measurements and Antibacterial Effect
International Journal of Pharmaceutics, V. 607, 25 September 2021, 121013 doi:10.1016/j.ijpharm.2021.121013, IF=5.875 - Yu.V. Kharitonov, E.E. Shul'ts, T.V. Rybalova, A.V. Pavlova, T.G. Tolstikova
Synthetic Transformations of Higher Terpenoids. 40. Synthesis and Assessment of Analgesic Activity of N-Containing Derivatives of Lambertianic Acid Yu. V. Kharitonov, E. E. Shul’ts, T. V. Rybalova, A. V. Pavlova & T. G. Tolstikova
Chemistry of Natural Chemistry of Natural Compounds, 2021, V. 57, N 5, Pp 879-886 doi:10.1007/s10600-021-03502-y, IF=0.809 - O. Kazakova, E. Tret'yakova, D. Baev
Evaluation of A-azepano-triterpenoids and related derivatives as antimicrobial and antiviral agents
The Journal of Antibiotics, 2021, Vol. 74, N 9, Pp 559–573 doi: 10.1038/s41429-021-00448-9, IF=2.648 - N.V. Bulina, D.K. Rybin, S.V. Makarova, D.V. Dudina, I.S. Batraev, A.V. Utkin, I.Yu. Prosanov, M.V. Khvostov, V.Yu. Ulianitsky
Detonation Spraying of Hydroxyapatite on a Titanium Alloy Implant
Materials 2021, 14(17), 4852 doi:10.3390/ma14174852, IF=3.622 - S.V. Valiulin, A.A. Onischuk, A.M. Baklanov, S.N. Dubtsov, G.G. Dultseva, S.V. An'kov, T.G. Tolstikova, V.L. Rusinov, V.N. Charushin
An integrated aerosol setup for therapeutics and toxicological testing: generation techniques and measurement instrumentation
Measurement, 2021, V. 181, Art. Num.109659 doi:10.1016/j.measurement.2021.109659, IF=3.927 - A.O. Finke, M.Y. Ravaeva, V.I. Krasnov, I.V. Cheretaev, E.N. Chuyan, D.S. Baev, E.E. Shults
Cross-Coupling-Cyclocondensation Reaction Sequence to Access a Library of Ring-C Bridged Pyrimidino-tetrahydrothebaines and Pyrimidinotetrahydrooripavines
ChemistrySelect, 2021, V. 6,N 29, Pp 7391-7397 doi:10.1002/slct.202101790, IF=2.108 - N.S. Sirazhetdinova, V.A. Savelyev, D.S. Baev, T.S. Golubeva, L.S. Klimenko, T.G. Tolstikova, Ja. Ganbaatar, E.E. Shults
Synthesis, characterization and anticancer evaluation of nitrogen-substituted 1-(3-aminoprop-1-ynyl)-4-hydroxyanthraquinone derivatives
Medicinal Chemistry Research, 2021, V. 30, N. 8, Pp 1541-1556 doi:10.1007/s00044-021-02754-1, IF=1.965 - M.D. Semenova, S.A. Popov, T.S. Golubeva, D.S. Baev, E.E. Shults, M. Turks
Synthesis and Cytotoxicity of Sulfanyl, Sulfinyl and Sulfonyl Group Containing Ursane Conjugates with 1,3,4-Oxadiazoles and 1,2,4-Triazoles
ChemistrySelectб 2021, V. 6, N 7, Pp 6472-6477, This article also appears in:Medicinal Chemistry & Drug Discovery doi:10.1002/slct.202101594, IF=2.109 - A.O. Bryzgalov, T.A. Yakovleva, L.V. Politanskaya, I.Yu. Bagryanskaya, T.G. Tolstikova
Fluorinated 3,4-Dihydro-2H-1,4-Benzothiazin1,1-Dioxide Derivatives with Antiarrhythmic and Hypertensive Effects
American Journal of Biomedical Science & Research, 2021,13(4),328-338 doi:10.34297/AJBSR.2021.13.001882 - N.V. Terletskaya, N.K. Korbozova, N.O. Kudrina, T.N. Kobylina, M.S. Kurmanbayeva, N.D. Meduntseva, T.G. Tolstikova
The Influence of Abiotic Stress Factors on the Morphophysiological and Phytochemical Aspects of the Acclimation of the Plant Rhodiola semenowii Boriss
Plants, 2021, 10(6), 1196 doi:10.3390/plants10061196, IF=3.935 - M.A. Gromova, Yu.V. Kharitonov, S.A. Borisov, D.S. Baev, T.G. Tolstikova, E.E. Shul’ts
Synthetic Transformations of Higher Terpenoids. 39.* Synthesis and Analgesic Activity of Isopimaric Acid Derivatives
Chemistry of Natural Compounds (2021), 57, N 5, Pp 474-481 doi:10.1007/s10600-021-03391-1, IF=0.809 - M.V. Khvostov, M.S. Borisova, N.V. Bulina, S.V. Makarova, N.B. Dumchenko, T.G. Tolstikova, N.Z. Lyakhov
The influence of zinc and silicate ions on biological properties of hydroxyapatite synthesized by a mechanochemical method
Ceramics International, 2021, V. 47, N 7, Part A, Pp 9495-9503 doi:10.1016/j.ceramint.2020.12.083, IF=4.527 - COMPARATIVE PHARMACOKINETICS OF THE AEROSOL AND ORAL FORMS OF PYRAZINAMIDE/ An'kov S.V., Tolstikova T.G., Valiulin S.V., Onischuk A.A., Borisova M.S., Dubtsov S.N.// Chemistry for Sustainable Development. 2021. Т. 29. № 2. С. 224-228. doi:10.15372/CSD2021300
- Wei. Wei,V. I. Evseenko,M. V. Khvostov,S. A. Borisov,T. G. Tolstikova,N. E. Polyakov,A.V. Dushkin,Wenhao. Xu,Lu. Min ,Weike. Su
Solubility, Permeability, Anti-Inflammatory Action and In Vivo Pharmacokinetic Properties of Several Mechanochemically Obtained Pharmaceutical Solid Dispersions of Nimesulide
Molecules 2021, 26(6), 1513 doi:10.3390/molecules26061513, IF=4.411 - E. Shaydakov, V. Sannikov, V. Emelynenko, T. Tolstikova
First Experience of Using Russian Sulfacrylate Glue Clinical and Morphologic Study (In Vivo)
Journal of Vascular Surgery: Venous and Lymphatic Disorders, 2021, V. 9, N 2, Page 537 doi:10.1016/j.jvsv.2020.12.007, IF=2.859 - M.V. Khvostov, A.A. Chernonosov, S.A. Borisov, M.S. Borisova, E.S. Meteleva, V.I. Evseenko, N.E. Polyakov, A.V. Dushkin, T.G. Tolstikova
Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats
Therapeutic Delivery. 2021. V.12. N2. P.119-131 doi:10.4155/tde-2020-0115 - V.А. Proshchenkova, V.Yu. Shuvalov, L.V. Glyzdinskaya, A.S. Fisyuk, S.A. Chernenko, M.V. Khvostov, T.G. Tolstikova, M.А. Vorontsova, G.P. Sagitullina
Synthesis of 4-Ethoxycarbonyl(cyano)-β-Carbolines via Thermolysis of 4-Aryl-3(5)-Azidopyridine Derivatives and the Study of their Optical and Hypoglycemic Properties
Chemistry of Heterocyclic Compoundsб 2021, V. 57, N. 2, Pp 187-198 doi:10.1007/s10593-021-02892-9, IF=1.277 - S.S. Patrushev, L.G. Burova, A.A. Shtro, T.V. Rybalova, D.S. Baev, I.V. Shirokikh, A.N. Evstropov, E.E. Shults
Modifications of Isoalantolactone Leading to Effective Antibacterial and Antiviral Compounds
Letters in Drug Design & Discovery, 2021, V. 18 , N 7 , Pp 686 - 700 doi:10.2174/1570180817999201211193151, IF=1.15 - V. Fomenko, M. Blokhin, S. Kuranov, M. Khvostov, D. Baev, M.S. Borisova, O. Luzina, T.G. Tolstikova, N.F. Salakhutdinov
Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome
Sci. Pharm. 2021, 89(1), 4 doi:10.3390/scipharm89010004
2020- S.V. Valiulin, A.A. Onischuk, S.N. Dubtsov, A.M. Baklanov, S.V. An’kov, M.E. Plokhotnichenko, T.G. Tolstikova, G.G. Dultseva, V.L. Rusinov, V.N. Charushin, V.M. Fomin
Aerosol inhalation delivery of triazavirin in mice: outlooks for advanced therapy against novel viral infections
Journal of Pharmaceutical Sciences, 2021б V. 110, N 3, Pp 1316-1322 doi:10.1016/j.xphs.2020.11.016, IF=3.534 - A.S. Sokolova, O.I. Yarovaya, A.V. Zybkina, E.D. Mordvinova, N.S. Shcherbakova, A.V. Zaykovskaya, D.S. Baev, T.G. Tolstikova, D.N. Shcherbakov, O.V. Pyankov, R.A. Maksyutov, N.F. Salakhutdinov
Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process
European Journal of Medicinal Chemistry, 2020, V. 207, 112726 doi:10.1016/j.ejmech.2020.112726, IF=5.572 - K.P. Cheremnykh, V.A. Savelyev, S.A. Borisov, I.D. Ivanov, D.S. Baev, T.G. Tolstikova, V.A. Vavilin, E.E. Shults
Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency
Molecules 2020, 25(23), 5578 doi:10.3390/molecules25235578, IF=3.266 - S. Kuranov, O. Luzina, M. Khvostov, D. Baev, D. Kuznetsova, N. Zhukova, P. Vassiliev, A. Kochetkov, T. Tolstikova, N. Salakhutdinov
Bornyl Derivatives of p-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity
Pharmaceuticals 2020, 13(11), 404 doi:10.3390/ph13110404, IF=4.285 - B.M. Urbagarova, E.E. Shults, V.V. Taraskin, L.D. Radnaeva, T.N. Petrova, T.V. Rybalova, T.S. Frolova, A.G. Pokrovskii, Ja. Ganbaatar
Chromones and coumarins from Saposhnikovia divaricata (Turcz.) Schischk. Growing in Buryatia and Mongolia and their cytotoxicity
Journal of Ethnopharmacology, 2020, V. 261, 1125170 doi:10.1016/j.jep.2019.112517, IF=3.69 - S.A. Popov, M.D. Semenova, D.S. Baev, T.S. Frolova, M.A. Shestopalov, Ch. Wang, Zh. Qi, E.E. Shults, M. Turks
Synthesis and cytotoxicity of hybrids of 1,3,4- or 1,2,5-oxadiazoles tethered from ursane and lupane core with 1,2,3-triazole
Steroids, 2020, V. 162, , 108698 doi:10.1016/j.steroids.2020.108698, IF=1.948 - S.A. Popov, M. D. Semenova, D. S. Baev, T. S. Frolova, E. E.Shults,Ch.Wang, M.Turks
Synthesis of cytotoxic urs-12-ene- and 28-nor-urs-12-ene- type conjugates with amino- and mercapto-1,3,4-oxadiazoles and mercapto-1,2,4-triazoles
Steroids, 2020, V. 153, 108524 doi:10.1016/j.steroids.2019.108524, IF=1.948 - V.N. Davydova, I.V. Sorokina, A.V. Volod’ko, E.V. Sokolova, M.S. Borisova, I.M. Yermak
The Comparative Immunotropic Activity of Carrageenan, Chitosan and Their Complexes
Mar. Drugs 2020, 18(9), 458 doi:10.3390/md18090458, IF=4.72 - А.Б. Санников, Е.В. Шайдаков, В.М. Емельяненко, Т.Г. Толстикова
Экспериментальное клиническое исследование по использованию отечественного адгезива в облитерации варикозно измененных вен у человека
Стационарозамещающие технологии: Амбулаторная хирургия. 2020. № 3-4. С. 113-123. doi:10.21518/1995-1477-2020-3-4-113-123 - Yu.I. Glazachev, A.A. Schlotgauer, V.A. Timoshnikov, P.A. Kononova, O.Yu. Selyutina, E.A. Shelepova, M.V. Zelikman, M.V. Khvostov, N.E. Polyakov
Effect of Glycyrrhizic Acid and Arabinogalactan on the Membrane Potential of Rat Thymocytes Studied by Potential-Sensitive Fluorescent Probe
The Journal of Membrane Biology, 2020, V. 253, Pp 343-356 doi:10.1007/s00232-020-00132-3, IF=1.876 - A.A. Kotlyarova, K.Yu. Ponomarev, E.A. Morozova, D.V. Korchagina, E.V. Suslov, A.V. Pavlova, T.G. Tolstikova, K.P. Volcho, N.F. Salakhutdinov
Effect of bispidine containing monoterpenoid moieties on physical performance in mice
2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB), Novosibirsk, Russia, 2020, pp. 114-117 doi:10.1109/CSGB51356.2020.9214697 - V.A. Demina, S.V. Krasheninnikov, A.I. Buzin, R.A. Kamyshinsky, N.V. Sadovskaya, E.N.Goncharov, N.A. Zhukova, M.V. Khvostov, A.V. Pavlova, T.G. Tolstikova, N.G. Sedush, S.N. Chvalun
Biodegradable poly(l-lactide)/calcium phosphate composites with improved properties for orthopedics: Effect of filler and polymer crystallinity
Materials Science and Engineering: C, 2020, V. 112, 110813 doi:10.1016/j.msec.2020.110813, IF=5.88 - T.S. Khlebnicova, Yu.A. Piven, F.A. Lakhvich, I.V. Sorokina, T.S. Frolova, D.S. Baev, T.G. Tolstikova
Betulinic Acid-Azaprostanoid Hybrids: Synthesis and Pharmacological Evaluation as Anti-inflammatory Agents
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, (Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents), 2020, V. 19, N 3, Pp 254-267 doi:10.2174/1871523018666190426152049 - N.S. Li-Zhulanov, A.V. Pavlova, D.V. Korchagina, Yu.V. Gatilov, K.P. Volcho, T.G. Tolstikova, N.F. Salakhutdinov
Synthesis of 1,3-Oxazine Derivatives Based on (-)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity
Chemistry of Heterocyclic Compounds, 2020, V. 56, N 7, Pp 936-941 doi:10.1007/s10593-020-02753-x, IF=1.519 - O.I. Brusentseva, Yu.V. Kharitonov, M.P. Dolgikh, T.G. Tolstikova, E.E. Shul'ts
Synthesis and Analgesic Activity Assessment of Furanolabdanoid Conjugates with Glucuronic Acid
Chemistry of Natural Compounds, 2020, V. 56, N 4, Pp 678-687 doi:10.1007/s10600-020-03119-7, IF=0.653 - NEW APPROACHES TO INCREASING THE EFFECTIVENESS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS USING NANOSCALE DELIVERY SYSTEMS/ POLYAKOV N. E., VALIULIN S. V., ONISCHUK A. A., TOLSTIKOVA T. G.//
- I.А. Novakov, L.L. Brunilina, I.А. Kirillov, M.B. Nawrozkij, M.D. Robinovich, E.S. Titova, D.S. Sheikin, E.А. Ruchko, A.V. Pavlova, A.А. Kotlyarova, T.G. Tolstikova
The synthesis of new acyclic analogs of 3-phenacyluridine and comparative evaluation of their in vivo biological activity
Chemistry of Heterocyclic Compounds, 2020, V. 56, N 6, Pp 769-775 doi:10.1007/s10593-020-02729-x, IF=1.519 - A Method for Generating an Aerosol of the Antibacterial Medicine Cefazolin/ A. A. Bazhina, S. V. Valiulin, A. M. Baklanov, S. N. Dubtsov, S. V. An’kov, M. E. Plokhotnichenko, T. G. Tolstikova, A. A. Onischuk// Atmospheric and Oceanic Optics, 2020, V. 33, N 6, Pp 555-558 doi:10.1134/S1024856020050048
- N.S. Sirazhetdinova, V.A. Savelyev, T.S. Frolova, D.S. Baev, L.S. Klimenko, I.V. Chernikov, O.S. Oleshko, T.A. Sarojan, A.G. Pokrovskii, E.E. Shults
1-Hydroxyanthraquinones Containing Aryl Substituents as Potent and Selective Anticancer Agents
Molecules 2020, 25(11), 2547 doi:10.3390/molecules25112547, IF=3.267 - I. Il'ina, E. Morozova, A. Pavlova, D. Korchagina, T. Tolstikova, K. Volcho, N. Salakhutdinov
Synthesis and analgesic activity of aliphatic ketones-derived chiral hexahydro-2H-chromenes
Medicinal Chemistry Research, 2020, V. 29, N 4, pp 738-747 doi:10.1007/s00044-020-02518-3, IF=1.783 - Study of Plant Coumarins. 18. Coumarin Conjugates with Lupane Triterpenoidsand 1,2,3-triazoles: Synthesis and Anti-inflammatory Activity/ Lipeeva A. V., Dolgikh М. Р., Tolstikova T. G., Shults E. E// Russian Journal of Bioorganic Chemistry, 2010, V. 46, N 2, Pp125-132 doi:10.1134/S1068162020010161, IF=0.682
- Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety/ M.E. Mironov, A.I. Poltanovich , T.V., Rybalova, M.P. Dolgikh, T.G. Tolstikova, E.E Shults// Russian Chemical Bulletin, 2020, V. 69, Pp 537–546 doi:10.1007/s11172-020-2795-6, IF=1.061
- A.A. Kotlyarova, K.Yu. Ponomarev, E.A. Morozova, D.V. Korchagina, E.V. Suslov, A.V. Pavlova, T.G. Tolstikova, K.P. Volcho, N.F. Salakhutdinov
The effect of 3,7-diazabicyclo[3.3.1]nonanes containing monoterpenoid moieties on the physical activity of mice
Journal of research in pharmacy, 2020, V. 24, N 2, Pp 196-204 doi:10.35333/jrp.2020.136 - Prostatotropic action of glycyrrhizic acid disodium salt in modeling benign prostatic hyperplasia/ Nizomov S.A., Sorokina I.V., Zhukova N.A., Borisov S.A., Tolstikova T.G., Semenov D.E., Bakarev M.A.// Bulletin of Experimental Biology and Medicine, 2020, V. 169, N 1, Pp 114-118 doi:10.1007/s10517-020-04836-3, IF=0.775
- I. Il'ina, E. Morozova, D. Korсhagina, K. Volcho, T. Tolstikova, N. Salakhutdinov
Synthesis and Analgesic Activity of Monoterpenoid Aldehyde-derived Hydro-2H-chromeneols
Letters in Drug Design & Discovery, 2020, V. 17, N 1, Pp 68-78 doi:10.2174/1570180816666181114131220, IF=1.169 - A.A. Okhina, A.D. Rogachev, O.I. Yarovaya, M.V. Khvostov, T.G. Tolstikova, A.G. Pokrovsky, V.A. Khazanov, N.F. Salakhutdinov
Development and validation of an LC-MS/MS method for the quantitative analysis of the anti-influenza agent camphecene in rat plasma and its application to study the blood-to-plasma distribution of the agent
Journal of Pharmaceutical and Biomedical Analysis, 2020, V. 180, 113039 doi:10.1016/j.jpba.2019.113039, IF=3.209
2019- S.A. Kremis, D.S. Baev, A.V. Lipeeva, E.E. Shults, T.G. Tolstikova, O.I. Sinitsyna, A.V. Kochetov, T.S. Frolova
Genotoxic activity of 1,2,3-triazolyl modified furocoumarins and 2,3-dihydrofurocoumarins
Journal of biochemical and molecular toxicology, 2019, V. 33, N 11, e22396 doi:10.1002/jbt.22396, IF=2.965 - Application of Natural Polysaccharides in Pharmaceutics/ M.V. Khvostov, T.G. Tolstikova, S.A. Borisov, A.V. Dushkin// Russian Journal of Bioorganic Chemistry, 2019, V. 45, N 6, Pp 438-450 doi:10.1134/S1068162019060219, IF=0.794
- O.V. Ardashov, A.V. Pavlova, A.K. Mahato, Yu. Sidorova, E.A. Morozova, D.V. Korchagina, G.E. Salnikov, A.M. Genaev, O.S. Patrusheva, N. Li-Zhulanov, T.G. Tolstikova, K.P. Volcho, N. Salakhutdinov
A novel small molecule supports the survival of cultured dopamine neurons and may restore the dopaminergic innervation of the brain in the MPTP mouse model of Parkinson's disease
ACS Chemical Neuroscience, 2019, V. 10, N 10, Pp 4337-4349 doi:10.1021/acschemneuro.9b00396, IF=3.861 - S.A. Popov, M.D. Semenova, D.S. Baev, I.V. Sorokina, N.A. Zhukova, T.S. Frolova, T.G. Tolstikova, E.E. Shults, M. Turks
Lupane-type conjugates with aminoacids, 1,3,4- oxadiazole and 1,2,5-oxadiazole-2-oxide derivatives: synthesis, anti-inflammatory activity and in silico evaluation of target affinity
Steroids, 2019, V.150, 108443 doi:10.1016/j.steroids.2019.108443, IF=2.136 - O. Zakharova, G. Nevinsky, L. Politanskaya, D. Baev, L. Ovchinnikova, E. Tretyakov
Evaluation of antioxidant activity and cytotoxicity of polyfluorinated diarylacetylenes and indoles toward human cancer cells
Journal of Fluorine Chemistry, V. 226, October 2019, 109353 doi:10.1016/j.jfluchem.2019.109353, IF=2.055 - A. Predtetchinski, E. Predtechenskaya, I. Sorokina, A. Guzev, S. Aydagulova
Morphologic changes and protective role of prolactin in experimental multiple sclerosis animal model
MULTIPLE SCLEROSIS JOURNAL, 2019, V.25, S2, Pp 435-435 (P845) (35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS Местоположение: Stockholm, SWEDEN публ.: SEP 11-13, 2019 Конференция: 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual MULTIPLE SCLEROSIS JOURNAL Том: 25 Специальный выпуск: SI Приложение: 2 Стр.: 435-435 Аннотация к встрече: P845 Conference of Rehabilitation in MS Местоположение: Stockholm, SWEDEN публ.: SEP 11-13, 2019, IF=5.649 - Ultrastructure of the liver exposed to cyclophosphamide and triterpenoids/ O.P. Molodykh, I.V. Sorokina, E.V. Vinogradova, V.I. Kapustina, A.A. Khodakov// Bulletin of Experimental Biology and Medicine, 2020, V. 168, N 3, Pp 400-405 doi:10.1007/s10517-020-04718-8, IF=0.567
- Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides/ S. O. Kuranov, M. E. Blokhin, S. A. Borisov, M. V. Khvostov, O. A. Luzina, N. F. Salakhutdinov// Russian Journal of Bioorganic Chemistry, 2019, V. 45, N 5, pp 374-380 doi:10.1134/S1068162019050078, IF=0.794
- Cardioprotective Effect of p-Tyrosol in the Acute Period of Cardiovascular and Cerebral Ischemia/ A.P Krysin, I.V. Sorokina, E.E. Shults// Chemistry for Sustainable Development, 2019, V. 27, N 4, Pp 365-372 (in Russian) doi:10.15372/KhUR2019147
- T.S. Khlebnicova, Yu.A. Piven, A.V. Baranovsky, F.A. Lakhvich, I.V. Sorokina, T.G. Tolstikova
Fluorine-containing lupane triterpenoid acid derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory agents
Steroids, V.147, July 2019, Pp 62-69 doi:10.1016/j.steroids.2018.10.001, IF=2.136 - Supramolecular systems for the delivery of the molecules of medicinal substances based on water-soluble plant metabolites. physicochemical, pharmacological properties and the features of mechanochemical preparation/ Dushkin A.V., Meteleva E.S., Tolstikova T.G., Khvostov M.V., Polyakov N.E., Lyakhov N.Z.// Chemistry for Sustainable Development, 2019. V. 27, № 3. P. 233-244. (in Russian) doi:10.15372/KhUR2019129
- D. Avgustinovich, M. Tsyganov, G. Vishnivetskaya, А. Кovner, I. Sorokina, I. Orlovskaya, L. Toporkova, E. Goiman, T. Tolstikova, A. Dushkin, N. Lyakhov, V. Mordvinov
Effects of supramolecular complexation of praziquantel with disodium glycyrrhizinate on the liver fluke Opisthorchis felineus: an in vitro and in vivo study
Acta Tropica, 2019, V.194, Pp 1-12 doi:10.1016/j.actatropica.2019.03.017, IF=2.629 - T.S. Frolova, A.V. Lipeeva, D.S. Baev, S.I. Baiborodin, К.E. Orishchenko, A.V. Kochetov, O.I. Sinitsyna
Fluorescent labeling of ursolic acid with FITC for investigation of its cytotoxic activity using confocal microscopy
Bioorganic Chemistry, 2019, V. 87, Pp 876-887 doi:10.1016/j.bioorg.2018.11.052, IF=3.929 - Morphological analysis of prostatotropic activity of (3,5-dimethyl-4-hydroxy) benzyltiodyododecan in the model of benign prostatic hyperplasia in rats/ S.A. Nizomov, I.V. Sorokina, N.A. Zhukova, T.G. Tolstikova, D.E. Semenov, A.E. Prosenko// Bulletin of Experimental Biology and Medicine, 2019, V. 167, N 6, pp 809-812 doi:10.1007/s10517-019-04628-4, IF=0.567
- S.V. Valiulin, A.A. Onischuk, A.M. Baklanov, S.N. Dubtsov, S.V. An'kov, T.G. Tolstikova, M.E. Plokhotnichenko, G.G. Dultseva, P.S. Mazunina
Excipient-free isoniazid aerosol administration in mice: Evaporation-nucleation particle generation, pulmonary delivery and body distribution
International Journal of Pharmaceutics, 2019, V. 563, Pp 101-109 doi:10.1016/j.ijpharm.2019.03.050, IF=4.213 - T.M. Khomenko, D.V. Korchagina, D.S. Baev, P.M. Vassiliev, K.P. Volcho, N.F. Salakhutdinov
Antimicrobial Activity of Substituted Benzopentathiepin-6-amines
Journal of Antibiotics, 2019, V. 72, pp 590-599 doi:10.1038/s41429-019-0191-y, IF=2.446 - Q. Zhang, L. Suntsova, Yu.S. Chistyachenko, V. Evseenko, M.V. Khvostov, N.E. Polyakov, A.V. Dushkin, W. Su
Preparation, physicochemical and pharmacological study of curcumin solid dispersion with an arabinogalactan complexation agent
International Journal of Biological Macromolecules, V. 128, 1 May 2019, Pp 158-166 doi:10.1016/j.ijbiomac.2019.01.079, IF=4.784 - A.V. Lipeeva, A.O. Brysgalov, T.G. Tolstikova, E.E. Shults
Synthesis, Transformations and Characterization of 8 Aminomethyl Substituted Umbelliferones as Probable Anti-Arrhythmic Agents
Current Bioactive Compounds, 2019, V. 15 , N 1, Pp 71-82 Volume 15 , Issue 1 , 2019 doi:10.2174/1573407213666171030152601 - A.V. Lipeeva, D.O. Zakharov, L.G. Burova, T.S. Frolova, D.S. Baev, I.V. Shirokikh, A.N. Evstropov, O.I. Sinitsyna, T.G. Tolsikova, E.E. Shults
Design, Synthesis and Antibacterial Activity of Coumarin-1,2,3-triazole Hybrids Obtained from Natural Furocoumarin Peucedanin
Molecules 2019, 24(11), 2126 doi:10.3390/molecules24112126, IF=3.06 - Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones/ I. V. Il'ina, D. V. Korchagina, E. A. Morozova, T. G. Tolstikova, K. P. Volcho, N. F. Salakhutdinov// Russian Chemical Bulletin, 2019, V. 68, N 5, pp 1061-1066 doi:10.1007/s11172-019-2520-5, IF=1.014
- Synthesis, hypolipidemic and antifungal activity of tetrahydroberberrubine sulfonates/ I. V. Nechepurenko, E. D. Shirokova, M. V. Khvostov, T. S. Frolova, O. I. Sinitsyna, A. M. Maksimov, R. A. Bredikhin, N. I. Komarova, D. S. Fadeev, O. A. Luzina, T. G. Tolstikova, N. F. Salakhutdinova// Russian Chemical Bulletin, 2019, V. 68, N 5, pp 1052-1060 doi:10.1007/s11172-019-2519-y, IF=1.014
- Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections/ A. S. Sokolova, D. V. Baranova, O. I. Yarovaya, D. S. Baev, O. A. Polezhaeva, A. V. Zybkina, D. N. Shcherbakov, T. G. Tolstikova, N. F. Salakhutdinov// Russian Chemical Bulletin, 2019, V 68, N 5, pp 1041-1046 doi:10.1007/s11172-019-2517-0, IF=1.014
- E.S. Meteleva, Yu.S. Chistyachenko, L.P. Suntsova, M.V. Khvostov, N.E. Polyakov, O. Yu. Selyutina, T.G. Tolstikova, T.S. Frolova, V.A. Mordvinov, A.V. Dushkin, N.Z. Lyakhov
Disodium salt of glycyrrhizic acid - A novel supramolecular delivery system for anthelmintic drug praziquantel
Journal of Drug Delivery Science and Technology, V. 50, April 2019, Pp 66-77 doi:10.1016/j.jddst.2019.01.014, IF=2.606 - K.P. Cheremnykh, V.A. Savelyev, M.A. Pokrovskii, D.S. Baev, T.G. Tolstikova, A.G. Pokrovskii, E.E. Shults
Design, synthesis, cytotoxicity, and molecular modeling study of 2,4,6-trisubstituted pyrimidines with anthranilate ester moiety
Medicinal Chemistry Research, 2019, V. 28, N 4, pp 545–558 doi:10.1007/s00044-019-02314-8, IF=1.72 - D.O. Prima, A.G. Makarov, I.Yu. Bagryanskaya, A.E. Kolesnikov, L.V. Zargarova, D.S. Baev, T.F. Eliseeva, L.V. Politanskaya, A.Yu. Makarov, Yu.G. Slizhov, A. V. Zibarev
Fluorine-Containing n-6 and Angulaand Linear n-6-n' (n, n' = 5, 6, 7) Diaza-Heterocyclic Scaffolds Assembled on Benzene Core in Unified Way
ChemistrySelect, 2019, V. 4, N 8, Pp 2383-2386 doi:10.1002/slct.201803970, IF=1.716 - I.S. Merenkov, M.S. Myshenkov, Yu.M. Zhukov, Yo. Sato, T.S. Frolova, D.V. Danilov, I.A. Kasatkin, O.S. Medvedev, R.V. Pushkarev, O.I. Sinitsyna, M. Terauchi, I.A. Zvereva, M.L. Kosinova, K. Ostrikov
Orientation-controlled, low-temperature plasma growth and applications of h-BN nanosheets
Nano Research, 2019, V. 12, N 1, pp 91-99 doi:10.1007/s12274-018-2185-7, IF=8.515
2018- T.S. Khlebnikova, Yu.A. Piven', F.A. Lakhvich, T.S. Frolova, I.V. Sorokina, T.G. Tolstikova
Synthesis and Cytotoxicity of Conjugates of Betulinic Acid and F-Containing 2-Acylcycloalkane-1,3-Diones
Chemistry of Natural Compounds, 2018, V. 54, N 6, pp 1100-1105 doi:10.1007/s1060, IF=0.449 - Synthesis and Anti-Inflammatory Activity of Tyrosol and Its Structural Analogs/ A.P. Krysin, T.G. Tolstikova, M.P., E.E. Shul'ts , L.M. Pokrovskii// Pharmaceutical Chemistry Journal, 2019, V. 52, N 11, pp 907-911 doi:10.1007/s11094-019-01924-1, IF=0.679
- I.A. Orlovskaya, L.B. Toporkova, M.N. Lvova, I.V. Sorokina, A.V. Katokhin, G.B. Vishnivetskaya, E.V. Goiman, E.V. Kashina, T.G. Tolstikova, V.A. Mordvinov, D.F. Avgustinovich
Social Defeat Stress Exacerbates the Blood Abnormalities in Opisthorchis felineus-infected mice
Experimental Parasitology, 2018, V. 193, Pages 33-44 doi:10.1016/j.exppara.2018.08.004, IF=1.82 - R. Kong, X. Zhu, E.S. Meteleva, N.E. Polyakov, M.V. Khvostov, D.S. Baev, T.G. Tolstikova, A.V. Dushkin, W. Su
Atorvastatin calcium inclusion complexation with polysaccharide arabinogalactan and saponin disodium glycyrrhizate for increasing of solubility and bioavailability
Drug Delivery and Translational Research, 2018, V 8, N 5, pp 1200-1213 doi:10.1007/s13346-018-0565-x, IF=3.394 - Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host-C57BL/6 inbred mice/ M.A. Tsyganov, G.B. Vishnivetskaya, T.P. Kukina, I.V. Sorokina, M.N. Lvova, M.A. Protsenko, N.E. Kostina, D.F. Avgustinovich// VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII, , 2018, V. 22, N 7, Pp. 856-864 doi:10.18699/VJ18.426
- S.O. Kuranov, I.P. Tsypysheva, M.V. Khvostov, L.F. Zainullina, S.S. Borisevich, Yu.V. Vakhitova, O.A. Luzina, N.F. Salakhutdinov
Synthesis and evaluation of camphor and cytisine-based cyanopyrrolidines as DPP-IV inhibitors for the treatment of type 2 diabetes mellitus
Bioorganic & Medicinal Chemistry, 2018, V. 26, N 15, Pp 4402-4409 doi:10.1016/j.bmc.2018.07.018, IF=2.881 - Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt/ E.S. Meteleva, Yu.S. Chistyachenko, L.P. Suntsova, M.A. Tsyganov, G.B. Vishnivetskaya, D.F. Avgustinovich, M.V. Khvostov, N.E. Polyakov, T.G. Tolstikova, V.A. Mordvinov, A.V. Dushkin, N.Z. Lyakhov// Doklady Biochemistry and Biophysics, 2018, V. 481, N 1, pp 228-231 doi:10.1134/S1607672918040142, IF=0.61
- Accessible Metabolites from Siberian Plants for Development and Production of Innovative Drugs/ T.G. Tolstikova, I.V. Sorokina, N.A. Zukova, E.A. Morosova, YU.V. Kharitonov, M.E. Mironov, S.A. Popov, E.E. Shults// doi:10.15372/KhUR20180308
- Differentially expressed neurotransmitter genes in the dorsal striatum of male mice with psychomotor disturbances/ D.A. Smagin, A.G. Galyamina, I.L. Kovalenko, V.N. Babenko, N.V. Tamkovich, S.A. Borisov, T.G. Tolstikova, N.N. Kudryavtseva// Zhurnal vysshei nervnoi deyatelnosti imeniI I P Pavlova, 2018, V. 68, N 2, Pp 227-249 doi:10.7868/S0044467718020089, IF=0.31
- Antiulcer and anti-inflammatory activity of the campholenic aldehyde-derived thiazolidinone/ BORISOVA Marina Sergeevna, SOKOLOV Dmitriy Nikolaevich, ZHUKOVA Natalya Anatolevna, TOLSTIKOVA Tatyana Genrikhovna, SALAKHUTDINOV Nariman Faridovich// doi:10.15372/SSMJ20180201
- Т.С. Фролова, С.Ж. Шарапов, О.И. Синицина, Т.Г. Толстикова, И.А. Григорьев, С.В. Морозов, Ю.В. Юшкова
Новые ионные конъюгаты на основе a-токоферилсукцината как потенциальные цитотоксические агенты1
Биоорганическая химия. 2018. Т. 44. № 3. С. 325-332. doi:10.7868/S0132342318030089, IF=0.838 - Antiulcerogenic activity of borneol derivatives/ M. S. Borisova, O. I. Yarovaya, M. D. Semenova, T. G. Tolstikova, N. F. Salakhutdinov// Russian Chemical Bulletin, 2018, V. 67, N 3, Pp 558-561 doi:10.1007/s11172-018-2110-y, IF=0.781
- A.O. Bryzgalov, T.G. Tolstikova, E.E. Shults, K.O. Petrova
Natural Products as a Source of Antiarrhythmic Drugs
Mini-Reviews in Medicinal Chemistry, 2018, V. 18, N 4, Pp 345 - 362 doi:10.2174/1389557516666161104144815, IF=2.645 - Q. Zhang, N.E. Polyakov, Yu.S. Chistyachenko, M.V. Khvostov, T.S. Frolova, T.G. Tolstikova, A.V. Dushkin, W. Su
Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry
Drug Delivery, 2018, V. 25, N 1, P. 198-209 doi:10.1080/10717544.2017.1422298, IF=3.095 - Avgustinovich D.F., Katokhin A.V., Kontsevaya G.V., Lvova M.N., Vishnivetskaya G.B., Kashina E.V., Marenina M.K., Maksimova G.A., Zav'yalov E.L., Mordvinov V.A.
A comparative study of opistrorchis felineus (RIVOLTA, 1884) infection in inbred C57BL/6 AND outbred CD-1 mice
Паразитология. 2018. Т. 52. № 1. С. 19-31
2017- R. Kong, X. Zhu, E.S. Meteleva, Yu.S. Chistyachenko, L.P. Suntsova, N.E. Polyakov, M.V. Khvostov, D.S. Baev, T.G. Tolstikova, J. Yu, A.V. Dushkin, W. Su
Enhanced solubility and bioavailability of simvastatin by mechanochemically obtained complexes
International Journal of Pharmaceutics, 2017, V. 534, N 1-2, Pp 108-118 doi:10.1016/j.ijpharm.2017.10.011, IF=3.648 - K.Yu. Ponomarev, E.A. Morozova, E.V. Suslov, D.V. Korchagina, T.G. Tolstikova, K.P. Volcho, N.F. Salakhutdinov
Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties
Chemistry of Natural Compounds, 2017, V. 53, N 6, Pp 1131-1136 doi:10.1007/s10600-017-2216-8, IF=0.46 - O.S. Patrusheva, A.V. Pavlova, D.V. Korchagina, T.G. Tolstikova, K.P. Volcho, N.F. Salakhutdinov
Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2-Chromen-4,8-Diols Containing Alkyl-Substituted Aromatic Moieties
Chemistry of Natural Compounds, 2017, V. 53, N 6, Pp 1066-1071 doi:10.1007/s10600-017-2202-1, IF=0.46 - I.M. Yermak, N.P. Mischchenko, V.N. Davydova, V.P. Glazunov, D.V. Tarbeeva, A.O. Kravchenko, E.A. Pimenova, I.V. Sorokina
Carrageenans-Sulfated Polysaccharides from Red Seaweeds as Matrices for the Inclusion of Echinochrome
Marine drugs, 2017, V. 15 , N 11 , Art Number 337 doi:10.3390/md15110337, IF=3.503 - I.I. Popadyuk, A.V. Markov, E.A. Morozova, V.O. Babich, O.V. Salomatina, E.B. Logashenko, M.A. Zenkova, T.G. Tolstikova, N.F. Salakhutdinov
Synthesis and evaluation of antitumor, anti-inflammatory and analgesic activity of novel deoxycholic acid derivatives bearing aryl- or hetarylsulfanyl moieties at the C-3 position
Steroids, 2017, V. 127, Pp 1-12 doi:10.1016/j.steroids.2017.08.016, IF=2.282 - A.V. Lipeeva, D.S. Baev, M.P. Dolgikh, T.G. Tolstikova, E.E. Shults
Rapid Access to Oxazine Fused Furocoumarins and in vivo and in silico Studies of theirs Biological Activity
Medicinal Chemistry, 2017, V.13, N 7, Pp 625-632 doi:10.2174/1573406413666170601114527, IF=2.331 - A. Predtetchinsk, E. Predtechenskaya, I. Sorokina, A. Guzev
Gender features of hyperprolactinemia as a protective factor in animal models of multiple sclerosis
Multiple sclerosis journal, 2017, V. 23, Pp 769-769, Приложение: 3 Аннотация к встрече: EP1463 (7th Joint European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS)-Americas-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ACTRIMS), Paris, FRANCE, Oct 25-28, 2017) doi:10.1177/1352458517731285, IF=4.84 - A.G. Galyamina, D.A. Smagin, I.L. Kovalenko, T.G. Tolstikova, N.N. Kudryavtseva
Psychomotor disturbances and changes in the expression of neurotransmitter genes in the dorsal striatum of aggressive and defeated male mice
European Neuropsychopharmacology, 2017, V. 27, pp S677-S677, S4 (30th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Paris, France, Sep 02-05, 2017) doi:10.1016/S0924-977X(17)31260-9, IF=4.238 - D.O. Prima, D.S. Baev, E.V. Vorontsova, T.S. Frolova, I.Yu. Bagryanskaya, Yu.G. Slizhov, T.G. Tolstikova, A.Yu. Makarov, A.V. Zibarev
New cancer cells apoptosis agents: Fluorinated aza-heterocycles
AIP Conference Proceedings, V. 1882, N 1, 020057 (2017) (Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17), 23-26 May 2017, Tomsk, Russia) doi:10.1063/1.5001636 - Journal of Physics: Conference Series Volume 886, Issue 1, 29 August 2017, Номер статьи 012005/ // doi:10.1088/1742-6596/886/1/012005
- G.A. Maksimova, M.Y. Pakharukova, E.V. Kashina, N.A. Zhukova, A.V. Kovner, M.N. Lvova, A.V. Katokhin, T.G. Tolstikova, B. Sripac, V.A. Mordvinov
Effect of Opisthorchis felineus infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian hamsters
Parasitology International, 2017, V. 66, N 4, Pp 458-463 doi:10.1016/j.parint.2015.10.002, IF=1.743 - С.А. Борисов, М.В. Хвостов, Т.Г. Толстикова, А.В. Душкин, Ю.С. Чистяченко
Фармакодинамические исследования комплекса включения Полисахарида лиственницы арабиногалактана с напроксеном
Сибирский научный медицинский журнал, ТОМ 37, № 4, 2017,С 19-25 - K. Ponomarev, E. Morozova, A. Pavlova, E. Suslov, D. Korchagina, A. Nefedov, T. Tolstikova, K. Volcho, N. Salakhutdinov
Synthesis and Analgesic Activity of Amines Combining Diazaadamantane and Monoterpene Fragments
Medicinal Chemistry, 2017, V. 13 , N 8, Pp 773 - 779 doi:10.2174/1573406413666170525124316, IF=2.331 - I. Il'ina, A. Pavlova, D. Korchagina, O. Ardashov, T. Tolstikova, K. Volcho, N. Salakhutdinov
Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes
Medicinal Chemistry Research, 2017, V. 26, N 7, pp 1415-1426 doi:10.1007/s00044-017-1847-4, IF=1.276 - M.V. Khvostov, S.A. Borisov, T.G. Tolstikova, A.V. Dushkin, B.D. Tsyrenova, Yu.S. Chistyachenko, N.E. Polyakov, G.G. Dultseva, A.A. Onischuk, S.V. An’kov
Supramolecular Complex of Ibuprofen with Larch Polysaccharide Arabinogalactan: Studies on Bioavailability and Pharmacokinetics
European Journal of Drug Metabolism and Pharmacokinetics, 2017, V. 42, N 3, pp 431-440 doi:10.1007/s13318-016-0357-y, IF=1.399 - Т.В. Попова, Н.О. Карабинцева, Л.Н. Рачковская, Т.Г. Толстикова, А.А. Котлярова, А.Ю. Летягин
Возможности создания полифункционального серебросодержащего препарата с детоксикационным эффектом
Фармация и фармакология. 2017. Т. 5. № 3. С. 242-253. doi:10.19163/2307-9266-2017-5-3-243-253 - Т.В. Попова, Н.О. Карабинцева, Т.Г. Толстикова
Исследование ассортимента лекарственных средств, применяемых в терапии острых кишечных инфекций
Журнал научных статей Здоровье и образование в XXI веке. 2017. Т. 19. № 10. С. 356-358. - А.Б. Киселев, А.Ю. Овчинников, Т.Г. Толстикова, В.А. Чаукина, Н.А. Мирошниченко, Н.А. Жукова
Транскутанная терапия назальной обструкции, сопровождающей интермиттирующий аллергический и острый инфекционный ринит
Эффективная фармакотерапия. 2017. № 14. С. 8-12. - В.И. Каледин, И.В. Сорокина, Н.А. Жукова, Т.Г. Толстикова, Л.А. Богданова, Т.С. Морозкова, Д.Е. Семенов
Усиление общетоксического и ослабление гепатотоксического действия диэтилнитрозамина при торможении его метаболизма у мышей
Российский физиологический журнал им. И.М. Сеченова. 2017. Т. 103. № 5. С. 527-532. - Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells/ T. S. Frolova, A. V. Lipeeva, D. S. Baev, Y. A. Tsepilov, O. I. Sinitsyna// Molecular Biology, 2017, V. 51, N 5, pp 705-711 doi:10.1134/S0026893317050090, IF=0.799
- A. Pavlova, O. Patrusheva, I. Il'ina, K. Volcho, T. Tolstikova, N. Salakhutdinov
The Decisive Role of Mutual Arrangement of Hydroxy and Methoxy Groups in (3(4)-hydroxy-4(3)-methoxyphenyl)-4,7-dimethyl-3,4,4a,5,8,8ahexahydro- 2H-chromene-4,8-diols in their Biological Activity
Letters in Drug Design & Discovery, 2017, V. 14, N 5, pp. 508-514 doi:10.2174/1570180813666161102142642, IF=1.169 - M. Yu. Khodanovich, I.V. Sorokina, V. Yu. Glazacheva, A.E. Akulov, N.M. Nemirovich-Danchenko, A.V. Romashchenko, T.G. Tolstikova, L.R. Mustafina, V.L. Yarnykh
Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model
Scientific Reports, 2017, 7, Article number: 46686 doi:10.1038/srep46686, IF=4.258 - Киселев А.Б., Овчинников А.Ю., Толстикова Т.Г., Чаукина В.А., Мирошниченко Н.А., Жукова Н.А.
Новый подход к ликвидации назальной обструкции при интермиттирующем аллергическом и остром инфекционном ринитах
Российская оториноларингология. 2017. № 2 (87). С. 131-136 - A.S. Sokolova, O.I. Yarovaya, A.A. Shtro, M.S. Borisova, E.A. Morozova, T.G. Tolstikova, V.V. Zarubaev, N.F. Salakhutdinov
Synthesis and biological activity of heterocyclic borneol derivatives
Chemistry of Heterocyclic Compounds, 2017, V. 53, N 3, pp 371-377 doi:10.1007/s10593-017-2063-3, IF=0.893 - T.A. Vaganova, A.I. Plekhanov, A.E. Simanchuk, S.L. Mikerin, E.V. Spesivtsev, E.V. Karpova, T.S. Frolova, E.V. Malykhin
Synthesis and characterization of novel polyhalogenaromatic polyimide material for electro-optic applications
Journal of Fluorine Chemistry, 2017, V. 195, Pp 70-78 doi:10.1016/j.jfluchem.2017.01.010, IF=2.101 - A.S. Sokolova, О.I. Yarovaya, D.S. Baev, А.V. Shernyukov, A.A. Shtro, V.V. Zarubaev, N.F. Salakhutdinov
Aliphatic and alicyclic camphor imines as effective inhibitors of influenza virus H1N1
European Journal of Medicinal Chemistry, 2017, V. 127, Pp 661-670 doi:10.1016/j.ejmech.2016.10.035, IF=4.519 - Л.Г. Бурова, И.В. Широких, С.С. Патрушев, Т.Г. Толстикова, Э.Э. Шульц
Взаимосвязь структура-антибактериальная активность в ряду производных изоалантолактона
Фундаментальная и клиническая медицина. 2017. Т. 2. № 1. С. 28-34.
2016- T.S. Khlebnicova, Y.A. Piven, F.A. Lakhvich, I.V. Sorokina, T.G. Tolstikova
Fluorine-containing lupane triterpenoid acid derivatives: synthesis and biological evaluation as potential anti-inflammatory agents
Известия Национальной академии наук Беларуси. Серия химических наук. Минск. “Беларуская навука.” 2016. C. 81-82. - S.I. Zhivetyeva, O.D. Zakharova, L.P. Ovchinnikova, D.S. Baev, I.Yu. Bagryanskaya, V.D. Shteingarts, T.G. Tolstikova, G.A. Nevinsky, E.V. Tretyakov
Phosphonium betaines derived from hexafluoro-1,4-naphthoquinone: Synthesis and cytotoxic and antioxidant activities
Journal of Fluorine Chemistry, V. 192, Part A, December 2016, Pp 68-77 doi:10.1016/j.jfluchem.2016.10.014, IF=2.213 - A.D. Rogachev, O.I. Yarovaya, S.V. Ankov, M.V. Khvostov, T.G. Tolstikova, A.G. Pokrovsky, N.F. Salakhutdinov
Development and validation of ultrafast LC–MS/MS method for quantification of anti-influenza agent camphecene in whole rat blood using dried blood spots and its application to pharmacokinetic studies
Journal of Chromatography B, Volumes 1036-1037, 15 November 2016, Pages 136-141 doi:10.1016/j.jchromb.2016.10.009, IF=2.687 - M.A. Gilinsky, T.P. Johnston, N.A. Zhukova, N.I. Dubrovina, T.V. Latysheva, S.E. Naumenko, R.A. Sukhovershin
Methylated arginine analogues: their potential role in atherosclerosis and cognition using the poloxamer-407-induced mouse model of dyslipidemia
Canadian Journal of Physiology and Pharmacology, 2016, V. 94, N 11, Pp 1122-1131 doi:10.1139/cjpp-2016-0104, IF=1.703 - DOI: 10.2174/1573406412666160129105115/ http://benthamscience.com/journals/medicinal-chemistry/article/138908/// doi:10.2174/1573406412666160129105115 , IF=1.457
- O.D. Zakharova, T.S. Frolova, Yu.V. Yushkova, E.I. Chernyak, A.G. Pokrovsky, M.A. Pokrovsky, S.V. Morozov, O.I. Sinitsina, I.A. Grigor'ev, G.A. Nevinsky
Antioxidant and antitumor activity of trolox, trolox succinate, an α-tocopheryl succinate conjugates with nitroxides
European Journal of Medicinal Chemistry, 2016, V. 122, Pages 127-137 doi:10.1016/j.ejmech.2016.05.051, IF=3.901 - I.V. Sorokina, T.G. Tolstikova, A.V. Volod'ko, I.M. Yermak
Modification of Biological Properties of k-Carrageenan in Polyionic Complexes with Chitosan
Achievements in the Life Sciences,2016, V. 10, Supplement, Page S51 (http://www.sciencedirect.com/science/article/pii/S2078152016301900) doi:10.1016/j.als.2016.12.050 - A.A. Onischuk, T.G. Tolstikova, S.V. An'kov, A.M. Baklanov, S.V. Valiulin, M.V. Khvostov, I.V. Sorokina, G.G. Dultseva, N.A. Zhukova
Ibuprofen, Indomethacin and Diclofenac Sodium Nanoaerosol: Generation, Inhalation Delivery and Biological Effects in Mice and Rats
Journal of Aerosol Science, V. 100, October 2016, Pp 164-177 doi:10.1016/j.jaerosci.2016.05.005, IF=2.278 - Dihydropyrimidin-2(1H)-one and its analogues as a platform for the design and synthesis of new biologically active compounds/ P Shkurko, T G Tolstikova, V F Sedova// RUSS CHEM REV, 2016, , 2016, 85 (10), 1056-1096 doi:10.1070/RCR4586, IF=3.687
- Т.С. Фролова, Д.С. Баев, О.И. Синицына
ИССЛЕДОВАНИЕ ЦИТОТОКСИЧЕСКИХ СВОЙСТВ ТРИТЕРПЕНОВЫХ КИСЛОТ ПРОТИВ КЛЕТОК ГЛИОМЫ
Успехи современной науки и образования. 2016. Т. 4. № 9. С. 14-18. - A.V. Pavlova, E.V. Nazimova, O.S. Mikhal'chenko, I.V. Il'ina, D.V. Korchagina, O.V. Ardashov, E.A. Morozova, T.G. Tolstikova, K.P. Volcho, N.F. Salakhutdinov
Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents
Chemistry of Natural Compounds, , 2016, V. 52, N 5, pp 813-820 doi:10.1007/s10600-016-1785-2, IF=0.472 - A. Sokolova, A. Pavlova, N. Komarova, O. Ardashov, A. Shernyukov, Yu. Gatilov, O. Yarovaya, T. Tolstikova, N. Salakhutdinov
Synthesis and analgesic activity of new α-truxillic acid derivatives with monoterpenoid fragments
Medicinal Chemistry Research, 2016, V. 25, N 8, pp 1608-1615 doi:10.1007/s00044-016-1593-z, IF=1.435 - Cardiotoxic and Dyslipidemic Effects of Doxorubicin and Betulinic Acid Amide/ M. G. Klinnikova, E. L. Lushnikova, E. V. Koldysheva, T. G. Tolstikova, I. V. Sorokina, E. I. Yuzhik, M. M. Mzhelskaya// Bulletin of Experimental Biology and Medicine,, 2016, V. 162, N 2, pp 277-282 doi:10.1007/s10517-016-3594-9, IF=0.448
- T.G. Tolstikova, M.V. Khvostov, N.A. Zhukova, N.V. Shikina, Ismagilov
Synthesis and safety evaluation of gold nanoparticles in the in vivo experiment
Химия в интересах устойчивого развития. 2016. Т. 24. № 4. С. 555-560. doi:10.15372/KhUR20160416 - E. Nazimova, A. Pavlova, O. Mikhalchenko, I. Il'ina, D. Korchagina, T. Tolstikova, K. Volcho, N. Salakhutdinov
Discovery of highly potent analgesic activity of isopulegol-derived (2R,4aR,7R,8aR)-4,7-dimethyl-2-(thiophen-2-yl)octahydro-2H-chromen-4-ol
Medicinal Chemistry Research, 2016, V. 25, N 7, pp 1369-1383 doi:10.1007/s00044-016-1573-3, IF=1.435 - Genotoxicity assessment of low-level doses of gamma radiation with the SOS chromotest and the Ames test/ A. Ya. Bolsunovsky, O. I. Sinitsyna, T. S. Frolova, E. A. Vasyunina, D. V. Dementyev// Doklady Biochemistry and Biophysics, July 2016, V. 469, N 1, pp 309-312 doi:10.1134/S1607672916040190, IF=0.393
- L.N. Rachkovskaya, T.V. Popova, A. Yu. Letyagin, T.G. Tolstikova, M.A. Korolyov, N. Bogdanchikova, A.N. Pestryakov, A.A. Kotlyarova, V. Burmistrov, V.I. Konenkov
Silver containing sorbents: Physicochemical and biological properties
Resource-Efficient Technologies, 2016, V. 2, N 2, Pages 43-49 doi:10.1016/j.reffit.2016.06.001 - DOI: 10.2174/1567201812666150605104944/ http://benthamscience.com/journals/current-drug-delivery/article/132016/// doi:10.2174/1567201812666150605104944, IF=1.445
- Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections/ S. O. Vechkapova, T. A. Zapara, E. A. Morozova, A. L. Proskura, E. E. Schul'ts, T. G. Tolstikova, A. S. Ratushnyak// Bulletin of Experimental Biology and Medicine doi:10.1007/s10517-016-3509-9, IF=0.448
- The effect of a lithium-containing composition on ethanol-induced changes in liver and brain within the experiments on mice/ Kotlyarova, A.Yu. Letyagin, T.G. Tolstikova, N.P. Bgatova, L.N. Rachkovskaya// The Siberian Scientific Medical Journal, 2015, V.. 35, № 2, 2015, Pp 29-34
- Research of the allergenic properties of new silver containing finely particulate sorbent/ T.V. Popova, T.G. Tolstikova, A.Yu. Letyagin, L.N. Rachkovskaya// The Siberian Scientific Medical Journal, 2015, V.. 35, № 2, 2015, Pp 24-28
- И.П. Жураковский, Т.Г. Толстикова, И.В. Сорокина, Н.А. Жукова, М.П. Борисова, И.О. Маринкин, А.И. Аутеншлюс
Эффективность применения β-аланинамида бетулоновой кислоты при стафиллококковом остеомиелите у крыс Вистар
Современные проблемы науки и образования. -2016. - № 5. (Электронный журнал) URL: https://www.science-education.ru/ru/article/view?id=25172. - Specific Features of Progression of the Parasitic Invasion, caused by Opisthorchis felineus, in Golden Hamsters/ D. E. Semenov, N. A. Zhukova, T. G. Tolstikova, I. V. Sorokina, E. L. Lushnikova// Bulletin of Experimental Biology and Medicine, 2016, V. 161, N 4, Pp 481-486 doi:10.1007/s10517-016-3443-x, IF=0.448
- D.F. Avgustinovich, M.K. Marenina, S.Ya. Zhanaeva, M.V. Tenditnik, A.V. Katokhin, K.S. Pavlov, A.Yu. Sivkov, G.B. Vishnivetskaya, M.N. Lvova, T.G. Tolstikova, V.A. Mordvinov
Combined effects of social stress and liver fluke infection in a mouse model
Brain, Behavior, and Immunity, 2016, V. 53, Pp 262-272 doi:10.1016/j.bbi.2016.01.012, IF=5.874 - Experimental Study of the Biocompatibility of Soft Tissues and a Finely Dispersed Sorbent Containing Silver/ T. V. Popova, T. G. Tolstikova, A. Yu. Letyagin, L. N. Rachkovskaya, V. A. Burmistrov// Pharmaceutical Chemistry Journal, 2016, V. 50, N 3, pp 152-155, IF=0.46
- И.В. Сорокина, Н.А. Жукова, Т.Г. Толстикова, С.А. Попов, Э.Э. Шульц
Бетамид - средство с противоопухолевой активностью, снижающее гепато- и нефротоксические эффекты цитостатической полихимиотерапии
Российский биотерапевтический журнал. 2016. Т. 15. № 1. С. 103-104. - M.K. Fomina, D.F. Avgustinovich, T.G. Tolstikova
Studies of the Effects of a Complex of Buspirone with Glycyrrhyzic Acid on the Behavior of Mice during Formation of an Anxious-Depressive State
Neuroscience and Behavioral Physiology, 2016, V. 46, N 2, pp 153-159 doi:10.1007/s11055-015-0212-7 - Synthesis, properties, and application of 4-nitrosemicarbazones/ V. S. Glukhacheva,S. G. Il'yasov, G. V. Sakovich, T. G. Tolstikova, A. O. Bryzgalov, N. V. Pleshkova// Russian Chemical Bulletin, February 2016, V. 65, N 2, pp 550-560 doi:10.1007/s11172-016-1336-9, IF=0.578
- T.A. Korolenko, T.P. Johnston, F.V. Tuzikov, N.A. Tuzikova, A.B. Pupyshev, V.K. Spiridonov, N.V. Goncharova, I.V. Maiborodin, N.A. Zhukova
Early-stage atherosclerosis in poloxamer 407-induced hyperlipidemic mice: pathological features and changes in the lipid composition of serum lipoprotein fractions and subfractions
Lipids in Health and Disease, 15:16, 22 January 2016 doi:10.1186/s12944-016-0186-7, IF=2.137 - Т.В. Попова, Т.Г. Толстикова, Л.Н. Рачковская
Исследование нового пористого носителя в серебросодержащей композиции на модели фарминдуцированных язв желудка и двенадцатиперстной кишки
Интер-медикал 2016, Т..17, N 1 , с.56-59 - V.A. D'yakonov, L.U. Dzhemileva, A.A. Makarov, A.R. Mulyukova, D.S. Baev, E.K. Khusnutdinova, T.G. Tolstikova, U.M. Dzhemilev
nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα
Medicinal Chemistry Research, 2016, V. 25, N 1, pp 30-39 doi:10.1007/s00044-015-1446-1, IF=1.435 - EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINS/ Popova T.V., Tolstikova T.G., Letyagin A.Yu., Zhukova N.A., Bgatova N.P., Rachkovskaya L.N., Kotlyrova A.A., Burmistrov V.A.// Byulleten Sibirskoy Meditsiny, 2016, Т. 15, № 1, С. 47-54 doi:10.20538/1682-0363-2016-1-47-54
- Effects of the lithium - containing sorbent on terms of behavioral reactions under chronic alcohol intoxication model/ A.A. Kotlyarova, A.Yu. Letyagin, T.G. Tolstikova, T.V. Popova, L.N. Rachkovskaya EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINS Popova T.V.1, Tolstikova T.G.2, Letyagin A.Yu.1, Zhukova N.A.2, Bgatova N.P.1, Rachkovskaya L.N.1, Kotlyrova A.A.1, Burmistrov V.A.1// Бюллетень сибирской медицины, 2016, Т. 15, № 1, С. 30-36. doi:10.20538/1682-0363-2016-1-30-36
2015- Yu.S. Chistyachenko, E.S. Meteleva, M.Y. Pakharukova, A.V. Katokhin, M.V. Khvostov, A.I. Varlamova, I.I. Glamazdin, S.S. Khalikov, N.E. Polyakov, I.A. Arkhipov, T.G. Tolstikova, V.A. Mordvinov, A.V. Dushkin, N.Z. Lyakhov
A Physicochemical and Pharmacological Study of the Newly Synthesized Complex of Albendazole and the Polysaccharide Arabinogalactan from Larch Wood
Current Drug Delivery, 2015, V. 12, N 5, Pp 477-490 doi:10.2174/1567201812666150518094739, IF=1.478 - K. Ponomarev, A. Pavlova, E. Suslov, O. Ardashov, D. Korchagina, A. Nefedov, T. Tolstikova, K. Volcho, N. Salakhutdinov
Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties
Medicinal Chemistry Research, 2015, V. 24, N 12, pp 4146-4156 doi:10.1007/s00044-015-1464-z, IF=1.401 - A. Pavlova, O. Mikhalchenko, A. Rogachev, I. Il'ina, D. Korchagina, Yu. Gatilov, T. Tolstikova, K. Volcho, N. Salakhutdinov
Synthesis and analgesic activity of stereoisomers of 2-(3(4)-hydroxy-4(3)-methoxyphenyl)-4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diols
Medicinal Chemistry Research, 2015, V 24, N 11, pp 3821-3830 doi:10.1007/s00044-015-1426-5, IF=1.401 - Siberian Opisthorchosis. Biology, Distribution and Development of New Preparations for Its Treatment/ MORDVINOV V.A., PAKHARUKOVA M. YU., KATOKHIN A.V., DUSHKIN A.V., CHISTYACHENKO YU. S., BELOUSOV A.I., KHVOSTOV M.V., ZHUKOVA N.A., KHALIKOV S.S., TOLSTIKOVA T.G., LYAKHOV N.Z.// doi:10.15372/KhUR20150511
- Investigation of degenerative processes in the femoral head of rats with prolonged alcohol intoxication/ A.G. Shusharin, M.S. Biruykova, M.P. Polovinka, N.A. Zhukova, T.G. Tolstikova// The Siberian Scientific Medical Journal, 2015, V. 35, № 4, Pp 4-8
- The morphofunctional and biochemical characteristics of opisthorchiasis-associated cholangiocarcinoma in a Syrian hamster model/ G. A. Maksimova , M. Y. Pakharukova, E. V. Kashina, N. A. Zhukova, M. N. Lvova, M. V. Khvostov, D. S. Baev, A. V. Katokhin, T. G. Tolstikova, V. A. Mordvinov// Russian Journal of Genetics: Applied Research, June 2016, V. 6, N 4, pp 454-462, doi:10.1134/S2079059716040134 doi:10.1134/S2079059716040134
- Д.Е. Семенов, Н.А. Жукова, Т.Г. Толстикова, И.В. Сорокина, М.С. Бирюкова, Е.П. Иванова
Патоморфогенез токсических поражений печени, индуцированных полихимиотерапией и тетрахлорметаном и их коррекция тритерпеновыми производными
В книге: ФУНДАМЕНТАЛЬНЫЕ АСПЕКТЫ КОМПЕНСАТОРНО-ПРИСПОСОБИТЕЛЬНЫХ ПРОЦЕССОВ МОЛЕКУЛЯРНО-КЛЕТОЧНЫЕ И МЕДИКО-ЭКОЛОГИЧЕСКИЕ ПРОБЛЕМЫ КОМПЕНСАЦИИ И ПРИСПОСОБЛЕНИЯ. Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт экспериментальной и клинической медицины». Ответственный редактор: академик РАН, доктор медицинских наук, профессор В.А. Шкурупий. Новосибирск, 2015. С. 259-260. - Е.А. Морозова, Т.Г. Толстикова, А.А. Старостенко, Т.Н. Быстрова
Исследование хронической токсичности декстразида
В книге: ФУНДАМЕНТАЛЬНЫЕ АСПЕКТЫ КОМПЕНСАТОРНО-ПРИСПОСОБИТЕЛЬНЫХ ПРОЦЕССОВ МОЛЕКУЛЯРНО-КЛЕТОЧНЫЕ И МЕДИКО-ЭКОЛОГИЧЕСКИЕ ПРОБЛЕМЫ КОМПЕНСАЦИИ И ПРИСПОСОБЛЕНИЯ. Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт экспериментальной и клинической медицины». Ответственный редактор: академик РАН, доктор медицинских наук, профессор В.А. Шкурупий. Новосибирск, 2015. С. 176-177. - I.V. Nechepurenko, U.A. Boyarskikh, M.V. Khvostov, D.S. Baev, N.I. Komarova, M.L. Filipenko, T.G. Tolstikova, N.F. Salakhutdinov
Hypolipidemic Berberine Derivatives with a Reduced Aromatic Ring C
Chemistry of Natural Compounds, 2015, V 51, N 5, pp 916-922 doi:10.1007/s10600-015-1447-9, IF=0.509 - Analgesic Effect of Several Nonsteroidal Anti-Inflammatory Drug Nanoaerosols/ S. V. An'kov, T. G. Tolstikova , A. A. Onishchuk, M. V. Khvostov, I. V. Sorokina, A. M. Baklanov, V. M. Fomin, V. V. Boldyrev// Pharmaceutical Chemistry Journal, 2016, V. 49, N 10, pp 680-682 doi:10.1007/s11094-016-1352-y, IF=0.451
- V.A. D'yakonov, L.U. Dzhemileva, A.A. Makarov, A.R. Mulyukova, D.S. Baev, E.K. Khusnutdinova, T.G. Tolstikova, U.M. Dzhemilev
11-Phenylundeca-5Z,9Z-dienoic Acid: Stereoselective Synthesis and Dual Topoisomerase I/IIα Inhibition
CURRENT CANCER DRUG TARGETS, 2015, V. 15, N 6, Pp 504-510 doi:10.2174/1568009615666150506093155, IF=3.522 - A.V. Lipeeva, M.A. Pokrovsky, D.S. Baev, M.M. Shakirov, I.Y. Bagryanskaya, T.G. Tolstikova, A.G. Pokrovsky, E.E. Shults
Synthesis of 1H-1,2,3-triazole linked aryl(arylamidomethyl) - dihydrofurocoumarin hybrids and analysis of their cytotoxicity
European Journal of Medicinal Chemistry, V.100, 2015, Pp 119-128 doi:10.1016/j.ejmech.2015.05.016, IF=3.447 - Magnetoelectric system for stimulation of hematopoiesis at decrease in quantity of blood cells and age changes of volume of red marrow Magnetoelectric system for stimulation of hematopoiesis at decrease in quantity of blood cells and age changes of volume of red marrow/ Belik D.V., Emtsev A.S., Schumeyko A.V., Khvostov M.V.//
- O. B. Shevelev, A.E. Akulov, A. S. Dotsenko, G. V. Kontsevaya, M. A. Zolotykh, L.A. Gerlinskaya, S. G. Veprev, T. N. Goryachkovskaya., N. A. Zhukova, N. A. Kolchanov, S. E. Pel'tek,M. P. Moshkin
Neurometabolic Effect of Altaian Fungus Ganoderma lucidum (Reishi Mushroom) in Rats Under Moderate Alcohol Consumption
Alcoholism: Clinical and Experimental Research, 2015, V. 39, N 7, pp 1128-1136. doi:10.1111/acer.12758, IF=3.205 - М.С. Бирюкова, Н.А. Жукова, И.В. Сорокина, Т.Г. Толстикова
Противоопухолевая и гепатопротекторная активность морфолиниламида дигидробетулоновой кислоты
В сборнике: НОВЫЕ ИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ, БИОЛОГИИ, ФАРМАКОЛОГИИ И ЭКОЛОГИИ материалы Международной конференции: Весенняя сессия. Под редакцией Е.Л. Глориозова. 2015. С. 302-311. - Н.А. Жукова, Т.Г. Толстикова, И.В. Сорокина, М.П. Бирюкова, Д.Е. Семенов
Патоморфология поражений печени различного генеза и их коррекция бетулоновой кислотой и ее амидом
В сборнике: НОВЫЕ ИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ, БИОЛОГИИ, ФАРМАКОЛОГИИ И ЭКОЛОГИИ материалы Международной конференции: Весенняя сессия. Под редакцией Е.Л. Глориозова. 2015. С. 251-263. - С.В. Аньков, Т.Г. Толстикова, А.А. Онищук, Н.А. Жукова, М.В. Хвостов
Токсико-фармакологические свойства наноаэрозольной формы нестероидных противовоспалительных средств
В сборнике: НОВЫЕ ИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ, БИОЛОГИИ, ФАРМАКОЛОГИИ И ЭКОЛОГИИ материалы Международной конференции: Весенняя сессия. Под редакцией Е.Л. Глориозова. 2015. С. 239-244. - Acetylenic derivatives of betulonic acid amide as a new type of compounds possessing spasmolytic activity/ A. I. Govdi, I. V. Sorokina, D. S. Baev, A. O. Bryzgalov, T. G. Tolstikova, G. A. Tolstikov, S. F. Vasilevsky// Russian Chemical Bulletin, 2015, V. 64, N 6, pp 1327-1334 doi:10.1007/s11172-015-1013-4, IF=0.481
- V. A. D'yakonov, L.U. Dzhemileva , A.A. Makarov, A. R. Mulukova, D. S. Baev, E. K. Khusnutdinova., T. G. Tolstikova , U. M. Dzhemilev
Stereoselective synthesis of 11-phenylundeca-5Z,9Z-dienoic acid and investigation of its human topoisomerase I and II alpha inhibitory activity
Bioorganic & Medicinal Chemistry Letters, V. 25, N 11, 2015, Pp 2405-2408 doi:10.1016/j.bmcl.2015.04.011, IF=2.42 - Yu.S. Chistyachenko, A.V. Dushkin, N.E. Polyakov, M.V. Khvostov, T.G. Tolstikova, G.A. Tolstikov, N.Z. Lyakhov
Polysaccharide arabinogalactan from larch Larix sibirica as carrier for molecules of salicylic and acetylsalicylic acid: preparation, physicochemical and pharmacological study
Drug Delivery, 2015, Vol. 22, No. 3 , Pages 400-407 doi:10.3109/10717544.2014.884655, IF=2.558 - Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine/ G. N. Zyuz’kov , V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, A. V. Chaikovskii, E. V. Simanina, T. Yu. Polyakova, M. Yu. Minakova, V. V. Udut, T. G. Tolstikova, E. E. Shul’ts, L. A. Stavrova, Ya. V. Burmina, N. I. Suslov, A. M. Dygai// Bulletin of Experimental Biology and Medicine, September 2015, V. 159, N 5, pp 642-645 doi:10.1007/s10517-015-3036-0, IF=0.358
- Г.А. Толстиков, А.Г. Толстиков, Т.Г. Толстикова
Берёза лечила и будет лечить
В сборнике: Береза Сборник статей. РОССИЙСКАЯ АКАДЕМИЯ НАУК; Институт лингвистических исследований; Санкт-Петербургский научный центр. Санкт-Петербург, 2015. С. 83-126. - Д.В. Белик, А.В. Шумейко, А.С. Емцев, М.В. Хвостов
Биотехническая система для стимуляции гемопоэза при сниженном количестве клеток крови и возрастных изменениях объема красного костного мозга
Научные исследования и разработки молодых ученых. 2015. № 4. С. 78-83. - Curare-like camphor derivatives and their biological activity/ A. S. Sokolova, E. A. Morozova, V. G. Vasilev, O. I. Yarovaya, T. G. Tolstikova, N. F. Salakhutdinov// Russian Journal of Bioorganic Chemistry, March 2015, Volume 41, Issue 2, pp 178-185 doi:10.1134/S1068162015020156, IF=0.535
- Yu.P. Bogza, A.L. Katsiel’, A.N. Sharypova, T.G. Tolstikova, A.S. Fisyuk
Synthesis and Biological Activity of 4H-Thieno[3,2-c]Chromene Derivatives
Chemistry of Heterocyclic Compounds, March 2015, Volume 50, Issue 12, pp 1712-1718 doi:10.1007/s10593-015-1642-4, IF=0.621 - Г.А. Максимова, Н.А. Жукова, Е.В. Кашина, М.Н. Львова, А.В. Катохин, Т.Г. Толстикова, В.А. Мордвинов
Роль opisthorchis felineus в индукции рака желчных протоков
Паразитология. 2015. Т. 49. № 1. С. 3-11. - A.I. Govdi, N.V. Sokolova, I.V. Sorokina, D.S. Baev, T.G. Tolstikova, V.I. Mamatyuk, D.S. Fadeev, S.F. Vasilevsky, V.G. Nenajdenko
Synthesis of new betulinic acid–peptide conjugates and in vivo and in silico studies of the influence of peptide moieties on the triterpenoid core activity
MedChemComm, 2015, V.6, N 1, pp. 230-238. doi:10.1039/c4md00236a, IF=2.495 - About the mechanism of membrane permeability enhancement by substances in their intermolecular complexes with polysaccharide arabinogalactan from larches Larix sibirica and Larix gmelinii/ A. V. Dushkin, Yu. S. Chistyachenko, D. A. Komarov, M. V. Khvostov, T. G. Tolstikova, I. F. Zhurko, I. A. Kirilyuk, I. A. Grigor’ev, N. Z. Lyakhov// Doklady Biochemistry and Biophysics, January 2015, Volume 460, Issue 1, pp 9-12 doi:10.1134/S1607672915010020, IF=0.343
- Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine/ G. N. Zyuz’kov, V. V. Zhdanov, L. A. Miroshnichenko, E. V. Udut, A. V. Chaikovskii, E. V. Simanina, M. G. Danilets, M. Yu. Minakova, V. V. Udut, T. G. Tolstikova, E. E. Shults, L. A. Stavrova, Ya. V. Burmina, A. M. Dygai// Bulletin of Experimental Biology and Medicine, 2015, V. 159, N 1, pp 58-61 doi:10.1007/s10517-015-2889-6, IF=0.358
- The synthesis and anti-inflammatory activity of propargylamino derivatives of naphthoquinonlevopimaric acid/ S. F. Vasilevsky, D. S. Baranov, A. I. Govdi, I. V. Sorokina, T. G. Tolstikova// Russian Journal of Bioorganic Chemistry, January 2015, Volume 41, Issue 1, pp 83-86 doi:10.1134/S1068162015010148, IF=0.535
- Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity/ M. P. Davydova, I. V. Sorokina, T. G. Tolstikova, V. I. Mamatyuk, D. S. Fadeev, S. F. Vasilevsky// Russian Journal of Bioorganic Chemistry, January 2015, Volume 41, Issue 1, pp 70-76 doi:10.1134/S1068162015010033, IF=0.535
- D. Pon'kina, S. Kuranov, M. Khvostov, N. Zhukova, Yu. Meshkova, M. Marenina, O. Luzina, T. Tolstikova, N. Salakhutdinov