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N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry
Of the Siberian Branch of Russian Academy of Science

 

Department of Medical Chemistry


Толстикова Т.Г.

Laboratory of Pharmacological Research (LPhI)


Head - Professor, Dr. Sci. Tatiana Genrikhovna Tolstikova

Phone: (383) 330-07-31
internal phone: 2-49
email:This email address is being protected from spambots. You need JavaScript enabled to view it.


The laboratory of pharmacological investigations was founded in 2000. From that moment more than 1000 novel compounds were tested by 60 experimental animal models, among them perspective opioid analgesic, antidepressant, nootropic, anxiolytic, anticonvulsant, muscle relaxant, hepatoprotector, cytostatic toxic effects corrector, antihypertensive, antiarrhythmic, antiulcer, anti-inflammatory, anti- hypercholesterolemia and antioxidant compounds were disclosed. Also compounds for the MR-tomography and nano-aerosol forms of water insoluble drugs were developed.


Staff

Employee Position Room Phone Phone in. email Publications
by yearsby tipeby If
1 Tolstikova Tatyana Genrikhovna Lab's Head (Doct. Biol.) М-3 330-07-31 2-49 This email address is being protected from spambots. You need JavaScript enabled to view it.
2 Sorokina Irina Vasilievna Leading Researcher (Doct.Biology) М-5, М-25 330-36-63 3-55 This email address is being protected from spambots. You need JavaScript enabled to view it.
3 Zhukova Natalia Anatolievna Leading Researcher (Doct. Med.) М-7 330-36-63 2-50 This email address is being protected from spambots. You need JavaScript enabled to view it.
4 Baev Dmitry Sergeevich Senior Researcher (Cand. Biol.) М-25а 330-36-63 3-55 This email address is being protected from spambots. You need JavaScript enabled to view it.
5 Morozova Ekaterina Aleksandrovna Senior Researcher (Cand. Biol.) М-24 330-36-63 4-34 This email address is being protected from spambots. You need JavaScript enabled to view it.
6 Khvostov Mikhail Vladimirovich Senior Researcher (Cand. Biol.) М-24 330-36-63 4-34 This email address is being protected from spambots. You need JavaScript enabled to view it.
7 Borisova Marina Sergeevna Researcher М-6 330-36-63 2-26 This email address is being protected from spambots. You need JavaScript enabled to view it.
8 An'kov Sergey Vladimirovich Researcher (Cand. Biol.) М-25 330-36-63 3-55
9 Borisov Sergey Alkisovich Researcher (Cand. Biol.) М-25 330-36-63 3-55
10 Bryzgalov Arkady Olegovich Researcher (Cand. Biol.) М-4 330-36-63 This email address is being protected from spambots. You need JavaScript enabled to view it.
11 Kotlyarova Anastasiya Anatolievna Researcher (Cand. Biol.) М-23, M-24 330-36-63 4-34
12 Pavlova Alla Viktorovna Researcher (Cand. Biol.) М-24 330-36-63 4-34 This email address is being protected from spambots. You need JavaScript enabled to view it.
13 Dumchenko Natalia Borisovna Junior Researcher
14 Marenina Mariya Konstantinovna Junior Researcher М-23 330-36-63 4-34
15 Simakova Olga Vladimirovna Junior Researcher
16 Dolgikh Margarita Petrovna Leading Engineer М-6 330-36-63 2-26 This email address is being protected from spambots. You need JavaScript enabled to view it.
17 Kosinova Ul'yana Vladimirovna engineer М-19, М-9 330-36-63 2-14, 2-62 This email address is being protected from spambots. You need JavaScript enabled to view it.
18 Nizomov Sirozhiddin Ashuralievich engineer М-5 330-36-63 3-55
19 Khodakov Anton Anatolievich engineer М-5 330-36-63 3-55
20 Zarembina Marina Fedorovna Senior Laboratory Assistant М-19 330-36-63 2-14
21 Sazonova Lyudmila Vyacheslavovna Senior Laboratory Assistant М-19 330-36-63 2-14
22 Tatarova Alexandra Sergeevna Senior Laboratory Assistant М-22 330-36-63 2-54 This email address is being protected from spambots. You need JavaScript enabled to view it.
23 Shmakova Ekaterina Sergeevna Senior Laboratory Assistant
24 Savchenko Elena Aleksandrovna technicist М-19 330-36-63 2-14
PHD Students
25 Zaigraev Vladimir Yurievich engineer М-5 330-36-63 3-55

Research areas:

The toxic-pharmacological investigation of low-molecular plant metabolites and their synthetic derivatives with the goal of original medications creation.

Plant metabolites chemistry. Medicinal chemistry. Pharmacological properties and mechanism of action investigation of novel drug agents of natural or synthetic origin.

 Pharmacological properties and mechanism of action investigation of novel drug agents derived by clathration with glycosides and polysaccharides.

Cytoprotective and antitumoral agents search among triterpenoids.

In vivo and in vitro investigation of analgesic, psychotropic and cardiotropic agent’s properties.

Pharmacological screening of novel biologically active plant and synthetic compounds.   

 

Main scientific results:

  • More than 1000 new compounds were investigated
  • More than 200 articles and 4 books were published
  •  12 PhD theses and 2 doctoral theses were defended
  • Next promising agents were found: “BETAMID”, “GLYCIDIPIN”, “FLUOGLISIN”, “DIOL”, “RNA-sin”, “BISULFAMIN”, “METILAN”, “FURALANIN”.